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1.
Discovery of TRPV1 antagonist ABT-116.
Bioorg Med Chem Lett
; 20(11): 3291-4, 2010 Jun 01.
Article
in English
| MEDLINE | ID: mdl-20457518
2.
Synthesis and biological evaluation of 5-substituted and 4,5-disubstituted-2-arylamino oxazole TRPV1 antagonists.
Bioorg Med Chem
; 18(13): 4821-9, 2010 Jul 01.
Article
in English
| MEDLINE | ID: mdl-20570528
3.
In vitro structure-activity relationship and in vivo characterization of 1-(aryl)-3-(4-(amino)benzyl)urea transient receptor potential vanilloid 1 antagonists.
J Med Chem
; 50(15): 3651-60, 2007 Jul 26.
Article
in English
| MEDLINE | ID: mdl-17583335
4.
Novel transient receptor potential vanilloid 1 receptor antagonists for the treatment of pain: structure-activity relationships for ureas with quinoline, isoquinoline, quinazoline, phthalazine, quinoxaline, and cinnoline moieties.
J Med Chem
; 48(3): 744-52, 2005 Feb 10.
Article
in English
| MEDLINE | ID: mdl-15689158
5.
Design, synthesis, and structure-activity relationship of 6-alkynylpyrimidines as potent adenosine kinase inhibitors.
J Med Chem
; 45(17): 3639-48, 2002 Aug 15.
Article
in English
| MEDLINE | ID: mdl-12166937
6.
Synthesis and structure-activity relationships of 5-heteroatom-substituted pyridopyrimidines as adenosine kinase inhibitors.
Eur J Med Chem
; 38(3): 245-52, 2003 Mar.
Article
in English
| MEDLINE | ID: mdl-12667691
7.
Discovery of (R)-1-(7-chloro-2,2-bis(fluoromethyl)chroman-4-yl)-3-(3-methylisoquinolin-5-yl)urea (A-1165442): a temperature-neutral transient receptor potential vanilloid-1 (TRPV1) antagonist with analgesic efficacy.
J Med Chem
; 57(17): 7412-24, 2014 Sep 11.
Article
in English
| MEDLINE | ID: mdl-25100568
8.
Selective blockade of TRPA1 channel attenuates pathological pain without altering noxious cold sensation or body temperature regulation.
Pain
; 152(5): 1165-1172, 2011 May.
Article
in English
| MEDLINE | ID: mdl-21402443
9.
4-amino-5-aryl-6-arylethynylpyrimidines: structure-activity relationships of non-nucleoside adenosine kinase inhibitors.
Bioorg Med Chem
; 15(4): 1586-605, 2007 Feb 15.
Article
in English
| MEDLINE | ID: mdl-17197188
10.
Alpha-methylation at benzylic fragment of N-aryl-N'-benzyl ureas provides TRPV1 antagonists with better pharmacokinetic properties and higher efficacy in inflammatory pain model.
Bioorg Med Chem Lett
; 17(14): 3894-9, 2007 Jul 15.
Article
in English
| MEDLINE | ID: mdl-17507218
11.
Structure-activity studies of a novel series of 5,6-fused heteroaromatic ureas as TRPV1 antagonists.
Bioorg Med Chem
; 14(14): 4740-9, 2006 Jul 15.
Article
in English
| MEDLINE | ID: mdl-16621571
12.
Synthesis and biological evaluation of 6,7-disubstituted 4-aminopyrido[2,3-d]pyrimidines as adenosine kinase inhibitors.
Bioorg Med Chem Lett
; 15(11): 2803-7, 2005 Jun 02.
Article
in English
| MEDLINE | ID: mdl-15911258
13.
5-(3-Bromophenyl)-7-(6-morpholin-4-ylpyridin-3-yl)pyrido[2,3-d]pyrimidin-4-ylamine: structure-activity relationships of 7-substituted heteroaryl analogs as non-nucleoside adenosine kinase inhibitors.
Bioorg Med Chem
; 13(11): 3705-20, 2005 Jun 01.
Article
in English
| MEDLINE | ID: mdl-15863000
14.
Synthesis and biological evaluation of pteridine and pyrazolopyrimidine based adenosine kinase inhibitors.
Bioorg Med Chem Lett
; 14(16): 4165-8, 2004 Aug 16.
Article
in English
| MEDLINE | ID: mdl-15261263
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