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1.
An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
Cell
; 179(2): 417-431.e19, 2019 Oct 03.
Article
in English
| MEDLINE | ID: mdl-31585081
2.
An Allosteric Anti-tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma.
Cell
; 180(2): 406, 2020 Jan 23.
Article
in English
| MEDLINE | ID: mdl-31978350
3.
Structure-based optimization of hydroxylactam as potent, cell-active inhibitors of lactate dehydrogenase.
Bioorg Med Chem Lett
; 59: 128576, 2022 03 01.
Article
in English
| MEDLINE | ID: mdl-35065235
4.
Dual functionality of ß-tryptase protomers as both proteases and cofactors in the active tetramer.
J Biol Chem
; 293(25): 9614-9628, 2018 06 22.
Article
in English
| MEDLINE | ID: mdl-29661938
5.
Potent and selective inhibitors of receptor-interacting protein kinase 1 that lack an aromatic back pocket group.
Bioorg Med Chem Lett
; 29(12): 1497-1501, 2019 06 15.
Article
in English
| MEDLINE | ID: mdl-31000154
6.
Water molecules in protein-ligand interfaces. Evaluation of software tools and SAR comparison.
J Comput Aided Mol Des
; 33(3): 307-330, 2019 03.
Article
in English
| MEDLINE | ID: mdl-30756207
7.
Metabolic plasticity underpins innate and acquired resistance to LDHA inhibition.
Nat Chem Biol
; 12(10): 779-86, 2016 10.
Article
in English
| MEDLINE | ID: mdl-27479743
8.
Identification of an imidazopyridine scaffold to generate potent and selective TYK2 inhibitors that demonstrate activity in an in vivo psoriasis model.
Bioorg Med Chem Lett
; 27(18): 4370-4376, 2017 09 15.
Article
in English
| MEDLINE | ID: mdl-28830649
9.
Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition.
Proc Natl Acad Sci U S A
; 111(22): 8025-30, 2014 Jun 03.
Article
in English
| MEDLINE | ID: mdl-24843152
10.
An allosteric switch for pro-HGF/Met signaling using zymogen activator peptides.
Nat Chem Biol
; 10(7): 567-73, 2014 Jul.
Article
in English
| MEDLINE | ID: mdl-24859116
11.
4-Aminoindazolyl-dihydrofuro[3,4-d]pyrimidines as non-covalent inhibitors of mutant epidermal growth factor receptor tyrosine kinase.
Bioorg Med Chem Lett
; 26(2): 534-539, 2016 Jan 15.
Article
in English
| MEDLINE | ID: mdl-26639762
12.
Discovery of highly potent and selective Bruton's tyrosine kinase inhibitors: Pyridazinone analogs with improved metabolic stability.
Bioorg Med Chem Lett
; 26(2): 575-579, 2016 Jan 15.
Article
in English
| MEDLINE | ID: mdl-26675441
13.
Diverse somatic mutation patterns and pathway alterations in human cancers.
Nature
; 466(7308): 869-73, 2010 Aug 12.
Article
in English
| MEDLINE | ID: mdl-20668451
14.
The trimeric serine protease HtrA1 forms a cage-like inhibition complex with an anti-HtrA1 antibody.
Biochem J
; 472(2): 169-81, 2015 Dec 01.
Article
in English
| MEDLINE | ID: mdl-26385991
15.
Identification of a small peptide that inhibits PCSK9 protein binding to the low density lipoprotein receptor.
J Biol Chem
; 289(2): 942-55, 2014 Jan 10.
Article
in English
| MEDLINE | ID: mdl-24225950
16.
Optimization of 5-(2,6-dichlorophenyl)-3-hydroxy-2-mercaptocyclohex-2-enones as potent inhibitors of human lactate dehydrogenase.
Bioorg Med Chem Lett
; 25(1): 75-82, 2015 Jan 01.
Article
in English
| MEDLINE | ID: mdl-25466195
17.
Identification of 3,6-disubstituted dihydropyrones as inhibitors of human lactate dehydrogenase.
Bioorg Med Chem Lett
; 24(24): 5683-5687, 2014 Dec 15.
Article
in English
| MEDLINE | ID: mdl-25467161
18.
Structure based design of novel 6,5 heterobicyclic mitogen-activated protein kinase kinase (MEK) inhibitors leading to the discovery of imidazo[1,5-a] pyrazine G-479.
Bioorg Med Chem Lett
; 24(19): 4714-4723, 2014 Oct 01.
Article
in English
| MEDLINE | ID: mdl-25193232
19.
Discovery and optimization of indazoles as potent and selective interleukin-2 inducible T cell kinase (ITK) inhibitors.
Bioorg Med Chem Lett
; 24(11): 2448-52, 2014 Jun 01.
Article
in English
| MEDLINE | ID: mdl-24767842
20.
Design, synthesis and structure-activity relationships of a novel class of sulfonylpyridine inhibitors of Interleukin-2 inducible T-cell kinase (ITK).
Bioorg Med Chem Lett
; 24(24): 5818-5823, 2014 Dec 15.
Article
in English
| MEDLINE | ID: mdl-25455497