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1.
Invention of MK-7845, a SARS-CoV-2 3CL Protease Inhibitor Employing a Novel Difluorinated Glutamine Mimic.
J Med Chem
; 67(5): 3935-3958, 2024 Mar 14.
Article
in English
| MEDLINE | ID: mdl-38365209
2.
Potent targeted activator of cell kill molecules eliminate cells expressing HIV-1.
Sci Transl Med
; 15(684): eabn2038, 2023 02 22.
Article
in English
| MEDLINE | ID: mdl-36812345
3.
A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells.
ACS Chem Biol
; 17(9): 2595-2604, 2022 09 16.
Article
in English
| MEDLINE | ID: mdl-36044633
4.
Pharmacological properties of MK-3207, a potent and orally active calcitonin gene-related peptide receptor antagonist.
J Pharmacol Exp Ther
; 333(1): 152-60, 2010 Apr.
Article
in English
| MEDLINE | ID: mdl-20065019
5.
Novel CGRP receptor antagonists from central amide replacements causing a reversal of preferred chirality.
Bioorg Med Chem Lett
; 20(22): 6827-30, 2010 Nov 15.
Article
in English
| MEDLINE | ID: mdl-20850973
6.
Identification of potent, highly constrained CGRP receptor antagonists.
Bioorg Med Chem Lett
; 20(8): 2572-6, 2010 Apr 15.
Article
in English
| MEDLINE | ID: mdl-20299218
7.
The discovery of highly potent CGRP receptor antagonists.
Bioorg Med Chem Lett
; 19(1): 214-7, 2009 Jan 01.
Article
in English
| MEDLINE | ID: mdl-19010673
8.
Novel CGRP receptor antagonists through a design strategy of target simplification with addition of molecular flexibility.
Bioorg Med Chem Lett
; 19(19): 5787-90, 2009 Oct 01.
Article
in English
| MEDLINE | ID: mdl-19703767
9.
The identification of potent, orally bioavailable tricyclic CGRP receptor antagonists.
Bioorg Med Chem Lett
; 19(16): 4740-2, 2009 Aug 15.
Article
in English
| MEDLINE | ID: mdl-19577468
10.
Pharmacological characterization of MK-0974 [N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]-4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxamide], a potent and orally active calcitonin gene-related peptide receptor antagonist for the treatment of migraine.
J Pharmacol Exp Ther
; 324(2): 416-21, 2008 Feb.
Article
in English
| MEDLINE | ID: mdl-18039958
11.
Potent benzimidazolone-based CGRP receptor antagonists.
Bioorg Med Chem Lett
; 18(23): 6122-5, 2008 Dec 01.
Article
in English
| MEDLINE | ID: mdl-18947992
12.
Design and Synthesis of Piperazine Sulfonamide Cores Leading to Highly Potent HIV-1 Protease Inhibitors.
ACS Med Chem Lett
; 8(12): 1292-1297, 2017 Dec 14.
Article
in English
| MEDLINE | ID: mdl-29259750
13.
Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group.
ACS Med Chem Lett
; 7(7): 702-7, 2016 Jul 14.
Article
in English
| MEDLINE | ID: mdl-27437081
14.
Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication.
J Med Chem
; 47(21): 5284-97, 2004 Oct 07.
Article
in English
| MEDLINE | ID: mdl-15456273
15.
Discovery of 3-substituted aminocyclopentanes as potent and orally bioavailable NR2B subtype-selective NMDA antagonists.
ACS Chem Neurosci
; 2(7): 352-62, 2011 Jul 20.
Article
in English
| MEDLINE | ID: mdl-22816022
16.
Discovery of MK-3207: A Highly Potent, Orally Bioavailable CGRP Receptor Antagonist.
ACS Med Chem Lett
; 1(1): 24-9, 2010 Apr 08.
Article
in English
| MEDLINE | ID: mdl-24900170
17.
Identification of novel, orally bioavailable spirohydantoin CGRP receptor antagonists.
Bioorg Med Chem Lett
; 16(24): 6165-9, 2006 Dec 15.
Article
in English
| MEDLINE | ID: mdl-17027263
18.
Non-peptide calcitonin gene-related peptide receptor antagonists from a benzodiazepinone lead.
Bioorg Med Chem Lett
; 16(10): 2595-8, 2006 May 15.
Article
in English
| MEDLINE | ID: mdl-16527483
19.
Identification of a key determinant of hepatitis C virus cell culture adaptation in domain II of NS3 helicase.
J Biol Chem
; 278(19): 16741-6, 2003 May 09.
Article
in English
| MEDLINE | ID: mdl-12615931
20.
A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties.
Antimicrob Agents Chemother
; 48(10): 3944-53, 2004 Oct.
Article
in English
| MEDLINE | ID: mdl-15388457
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