Search details
1.
Selective SERCA2a activator as a candidate for chronic heart failure therapy.
J Transl Med
; 22(1): 77, 2024 Jan 19.
Article
in English
| MEDLINE | ID: mdl-38243248
2.
Istaroxime Metabolite PST3093 Selectively Stimulates SERCA2a and Reverses Disease-Induced Changes in Cardiac Function.
J Pharmacol Exp Ther
; 384(1): 231-244, 2023 01.
Article
in English
| MEDLINE | ID: mdl-36153005
3.
Antihypertensive treatment guided by genetics: PEARL-HT, the randomized proof-of-concept trial comparing rostafuroxin with losartan.
Pharmacogenomics J
; 21(3): 346-358, 2021 06.
Article
in English
| MEDLINE | ID: mdl-33649520
4.
Personalized Therapy of Hypertension: the Past and the Future.
Curr Hypertens Rep
; 18(3): 24, 2016 Mar.
Article
in English
| MEDLINE | ID: mdl-26915067
5.
Ouabain Contributes to Kidney Damage in a Rat Model of Renal Ischemia-Reperfusion Injury.
Int J Mol Sci
; 17(10)2016 Oct 14.
Article
in English
| MEDLINE | ID: mdl-27754425
6.
Late sodium current (INaL) in pancreatic ß-cells.
Pflugers Arch
; 467(8): 1757-68, 2015 Aug.
Article
in English
| MEDLINE | ID: mdl-25236919
7.
Rostafuroxin protects from podocyte injury and proteinuria induced by adducin genetic variants and ouabain.
J Pharmacol Exp Ther
; 351(2): 278-87, 2014 Nov.
Article
in English
| MEDLINE | ID: mdl-25187430
8.
Early consequences of the phospholamban mutation PLN-R14del+/- in a transgenic mouse model.
Acta Physiol (Oxf)
; 240(3): e14082, 2024 Mar.
Article
in English
| MEDLINE | ID: mdl-38214033
9.
Preoperative endogenous ouabain predicts acute kidney injury in cardiac surgery patients.
Crit Care Med
; 41(3): 744-55, 2013 Mar.
Article
in English
| MEDLINE | ID: mdl-23314581
10.
Highly Selective SERCA2a Activators: Preclinical Development of a Congeneric Group of First-in-Class Drug Leads against Heart Failure.
J Med Chem
; 65(10): 7324-7333, 2022 05 26.
Article
in English
| MEDLINE | ID: mdl-35580334
11.
SERCA2a stimulation by istaroxime improves intracellular Ca2+ handling and diastolic dysfunction in a model of diabetic cardiomyopathy.
Cardiovasc Res
; 118(4): 1020-1032, 2022 03 16.
Article
in English
| MEDLINE | ID: mdl-33792692
12.
NKCC2 is activated in Milan hypertensive rats contributing to the maintenance of salt-sensitive hypertension.
Pflugers Arch
; 462(2): 281-91, 2011 Aug.
Article
in English
| MEDLINE | ID: mdl-21553016
13.
Structural and Electrophysiological Changes in a Model of Cardiotoxicity Induced by Anthracycline Combined With Trastuzumab.
Front Physiol
; 12: 658790, 2021.
Article
in English
| MEDLINE | ID: mdl-33897465
14.
Endogenous ouabain in cardiovascular function and disease.
J Hypertens
; 27(1): 9-18, 2009 Jan.
Article
in English
| MEDLINE | ID: mdl-19050443
15.
Istaroxime, a stimulator of sarcoplasmic reticulum calcium adenosine triphosphatase isoform 2a activity, as a novel therapeutic approach to heart failure.
Am J Cardiol
; 99(2A): 24A-32A, 2007 Jan 22.
Article
in English
| MEDLINE | ID: mdl-17239701
16.
Targeting Ouabain- and Adducin-dependent mechanisms of hypertension and cardiovascular remodeling as a novel pharmacological approach.
Med Hypotheses
; 68(6): 1307-14, 2007.
Article
in English
| MEDLINE | ID: mdl-17097240
17.
The endogenous ouabain: molecular basis of its role in hypertension and cardiovascular complications.
Front Biosci
; 10: 2472-7, 2005 Sep 01.
Article
in English
| MEDLINE | ID: mdl-15970509
18.
Quantitative proteomics reveals novel therapeutic and diagnostic markers in hypertension.
BBA Clin
; 2: 79-87, 2014 Dec.
Article
in English
| MEDLINE | ID: mdl-26672470
19.
Lack of salt-inducible kinase 2 (SIK2) prevents the development of cardiac hypertrophy in response to chronic high-salt intake.
PLoS One
; 9(4): e95771, 2014.
Article
in English
| MEDLINE | ID: mdl-24752134
20.
Istaroxime stimulates SERCA2a and accelerates calcium cycling in heart failure by relieving phospholamban inhibition.
Br J Pharmacol
; 169(8): 1849-61, 2013 Aug.
Article
in English
| MEDLINE | ID: mdl-23763364