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1.
Trisubstituted ureas as potent and selective mPGES-1 inhibitors.
Bioorg Med Chem Lett
; 21(5): 1488-92, 2011 Mar 01.
Article
in English
| MEDLINE | ID: mdl-21295979
2.
Naphthalene/quinoline amides and sulfonylureas as potent and selective antagonists of the EP4 receptor.
Bioorg Med Chem Lett
; 21(3): 1041-6, 2011 Feb 01.
Article
in English
| MEDLINE | ID: mdl-21215624
3.
Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases.
Bioorg Med Chem Lett
; 21(1): 288-93, 2011 Jan 01.
Article
in English
| MEDLINE | ID: mdl-21106375
4.
Biarylimidazoles as inhibitors of microsomal prostaglandin E2 synthase-1.
Bioorg Med Chem Lett
; 20(23): 6978-82, 2010 Dec 01.
Article
in English
| MEDLINE | ID: mdl-20965723
5.
Discovery of MK-0952, a selective PDE4 inhibitor for the treatment of long-term memory loss and mild cognitive impairment.
Bioorg Med Chem Lett
; 20(22): 6387-93, 2010 Nov 15.
Article
in English
| MEDLINE | ID: mdl-20933411
6.
Discovery of disubstituted phenanthrene imidazoles as potent, selective and orally active mPGES-1 inhibitors.
Bioorg Med Chem Lett
; 19(20): 5837-41, 2009 Oct 15.
Article
in English
| MEDLINE | ID: mdl-19748780
7.
MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation.
J Pharmacol Exp Ther
; 326(3): 754-63, 2008 Sep.
Article
in English
| MEDLINE | ID: mdl-18524979
8.
Optimization and structure-activity relationship of a series of 1-phenyl-1,8-naphthyridin-4-one-3-carboxamides: identification of MK-0873, a potent and effective PDE4 inhibitor.
Bioorg Med Chem Lett
; 18(20): 5554-8, 2008 Oct 15.
Article
in English
| MEDLINE | ID: mdl-18835163
9.
Substituted phenanthrene imidazoles as potent, selective, and orally active mPGES-1 inhibitors.
Bioorg Med Chem Lett
; 17(24): 6816-20, 2007 Dec 15.
Article
in English
| MEDLINE | ID: mdl-18029174
10.
Lack of clinical efficacy of a phosphodiesterase-4 inhibitor for treatment of heaves in horses.
J Vet Intern Med
; 20(1): 175-81, 2006.
Article
in English
| MEDLINE | ID: mdl-16496938
11.
The C3a receptor antagonist SB 290157 has agonist activity.
Immunol Lett
; 100(2): 139-45, 2005 Sep 15.
Article
in English
| MEDLINE | ID: mdl-16154494
12.
Optimization of a tertiary alcohol series of phosphodiesterase-4 (PDE4) inhibitors: structure-activity relationship related to PDE4 inhibition and human ether-a-go-go related gene potassium channel binding affinity.
J Med Chem
; 46(12): 2413-26, 2003 Jun 05.
Article
in English
| MEDLINE | ID: mdl-12773045
13.
The discovery of setileuton, a potent and selective 5-lipoxygenase inhibitor.
ACS Med Chem Lett
; 1(4): 170-4, 2010 Jul 08.
Article
in English
| MEDLINE | ID: mdl-24900191
14.
Preparation of gamma,delta-Unsaturated beta-Ketophosphonates from Tertiary alpha-Allenic Alcohols. The Synthesis of (+/-)-(E)-alpha-Atlantone.
J Org Chem
; 61(20): 7202-7206, 1996 Oct 04.
Article
in English
| MEDLINE | ID: mdl-11667631
15.
Substituted coumarins as potent 5-lipoxygenase inhibitors.
Bioorg Med Chem Lett
; 16(9): 2528-31, 2006 May 01.
Article
in English
| MEDLINE | ID: mdl-16464579
16.
Dynamic activation of cystic fibrosis transmembrane conductance regulator by type 3 and type 4D phosphodiesterase inhibitors.
J Pharmacol Exp Ther
; 314(2): 846-54, 2005 Aug.
Article
in English
| MEDLINE | ID: mdl-15901792
17.
2,3-Diarylthiophenes as selective EP1 receptor antagonists.
Bioorg Med Chem Lett
; 15(4): 1155-60, 2005 Feb 15.
Article
in English
| MEDLINE | ID: mdl-15686932
18.
Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886.
Bioorg Med Chem Lett
; 15(14): 3352-5, 2005 Jul 15.
Article
in English
| MEDLINE | ID: mdl-15953724
19.
Substituted aminopyridines as potent and selective phosphodiesterase-4 inhibitors.
Bioorg Med Chem Lett
; 13(4): 741-4, 2003 Feb 24.
Article
in English
| MEDLINE | ID: mdl-12639571
20.
Catalytic inactivation of protein tyrosine phosphatase CD45 and protein tyrosine phosphatase 1B by polyaromatic quinones.
Biochemistry
; 43(14): 4294-303, 2004 Apr 13.
Article
in English
| MEDLINE | ID: mdl-15065873