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1.
Enantioselective Sulfonimidamide Acylation via a Cinchona Alkaloid-Catalyzed Desymmetrization: Scope, Data Science, and Mechanistic Investigation.
J Am Chem Soc
; 146(12): 8536-8546, 2024 Mar 27.
Article
in English
| MEDLINE | ID: mdl-38480482
2.
Umpolung Flow Chemistry for the Synthesis of a 3-Oxo-3H-spiro[benzofuran-2,4'-piperidine] Building Block.
J Org Chem
; 89(11): 7618-7629, 2024 Jun 07.
Article
in English
| MEDLINE | ID: mdl-38767619
3.
Data-Driven Multi-Objective Optimization Tactics for Catalytic Asymmetric Reactions Using Bisphosphine Ligands.
J Am Chem Soc
; 145(1): 110-121, 2023 01 11.
Article
in English
| MEDLINE | ID: mdl-36574729
4.
Data Science-Enabled Palladium-Catalyzed Enantioselective Aryl-Carbonylation of Sulfonimidamides.
J Am Chem Soc
; 145(38): 20959-20967, 2023 Sep 27.
Article
in English
| MEDLINE | ID: mdl-37656964
5.
Engineered Cytochrome P450-Catalyzed Oxidative Biaryl Coupling Reaction Provides a Scalable Entry into Arylomycin Antibiotics.
J Am Chem Soc
; 144(32): 14838-14845, 2022 08 17.
Article
in English
| MEDLINE | ID: mdl-35905381
6.
Atroposelective Negishi Coupling Optimization Guided by Multivariate Linear Regression Analysis: Asymmetric Synthesis of KRAS G12C Covalent Inhibitor GDC-6036.
J Am Chem Soc
; 144(45): 20955-20963, 2022 11 16.
Article
in English
| MEDLINE | ID: mdl-36326518
7.
Stereoselective Synthesis of the IDO Inhibitor Navoximod.
J Org Chem
; 87(7): 4955-4960, 2022 04 01.
Article
in English
| MEDLINE | ID: mdl-35317556
8.
Stereoconvergent and -divergent Synthesis of Tetrasubstituted Alkenes by Nickel-Catalyzed Cross-Couplings.
J Am Chem Soc
; 143(45): 19078-19090, 2021 11 17.
Article
in English
| MEDLINE | ID: mdl-34735129
9.
Achiral-Chiral Two-Dimensional Liquid Chromatography Platform to Support Automated High-Throughput Experimentation in the Field of Drug Development.
Anal Chem
; 92(22): 15187-15193, 2020 11 17.
Article
in English
| MEDLINE | ID: mdl-33142065
10.
Asymmetric Hydrogenation of Unfunctionalized Tetrasubstituted Acyclic Olefins.
Angew Chem Int Ed Engl
; 59(7): 2844-2849, 2020 02 10.
Article
in English
| MEDLINE | ID: mdl-31794118
11.
Convergent Synthesis of PI3K Inhibitor GDC-0908 Featuring Palladium-Catalyzed Direct C-H Arylation toward Dihydrobenzothienooxepines.
J Org Chem
; 84(8): 4796-4802, 2019 04 19.
Article
in English
| MEDLINE | ID: mdl-30543748
12.
Highly Efficient Synthesis of a Staphylococcus aureus Targeting Payload to Enable the First Antibody-Antibiotic Conjugate.
Chemistry
; 24(12): 2837-2840, 2018 Feb 26.
Article
in English
| MEDLINE | ID: mdl-29164727
13.
Synthesis of Selective Estrogen Receptor Degrader GDC-0810 via Stereocontrolled Assembly of a Tetrasubstituted All-Carbon Olefin.
J Org Chem
; 83(19): 11571-11576, 2018 10 05.
Article
in English
| MEDLINE | ID: mdl-30200756
14.
Lithium Hexamethyldisilazide-Mediated Enolization of Highly Substituted Aryl Ketones: Structural and Mechanistic Basis of the E/Z Selectivities.
J Am Chem Soc
; 139(35): 12182-12189, 2017 09 06.
Article
in English
| MEDLINE | ID: mdl-28786667
15.
Highly Stereoselective Synthesis of Tetrasubstituted Acyclic All-Carbon Olefins via Enol Tosylation and Suzuki-Miyaura Coupling.
J Am Chem Soc
; 139(31): 10777-10783, 2017 08 09.
Article
in English
| MEDLINE | ID: mdl-28715208
16.
High-throughput chemical modification of oligonucleotides for systematic structure-activity relationship evaluation.
Bioconjug Chem
; 25(12): 2222-32, 2014 Dec 17.
Article
in English
| MEDLINE | ID: mdl-25398098
17.
Asymmetric Synthesis of N-Alkyl Amino Acids through a Biocatalytic Dynamic Kinetic Resolution of PEGylated N-Alkyl Amino Esters.
Org Lett
; 25(49): 8927-8931, 2023 12 15.
Article
in English
| MEDLINE | ID: mdl-38051775
18.
Second-Generation Atroposelective Synthesis of KRAS G12C Covalent Inhibitor GDC-6036.
Org Lett
; 25(19): 3417-3422, 2023 May 19.
Article
in English
| MEDLINE | ID: mdl-37162129
19.
Iridium-monodentate phosphoramidite-catalyzed asymmetric hydrogenation of substituted benzophenone N-H imines.
J Am Chem Soc
; 132(7): 2124-5, 2010 Feb 24.
Article
in English
| MEDLINE | ID: mdl-20104899
20.
A safe and practical procedure for global deprotection of oligoribonucleotides.
J Org Chem
; 75(15): 5305-7, 2010 Aug 06.
Article
in English
| MEDLINE | ID: mdl-20670035