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1.
Evaluation of the Absorption, Metabolism, and Excretion of a Single Oral 1-mg Dose of Tropifexor in Healthy Male Subjects and the Concentration Dependence of Tropifexor Metabolism.
Drug Metab Dispos
; 49(7): 548-562, 2021 07.
Article
in English
| MEDLINE | ID: mdl-33952610
2.
Evaluation of Clinical Drug Interaction Potential of Clofazimine Using Static and Dynamic Modeling Approaches.
Drug Metab Dispos
; 46(1): 26-32, 2018 01.
Article
in English
| MEDLINE | ID: mdl-29038231
3.
Simultaneous Physiologically Based Pharmacokinetic (PBPK) Modeling of Parent and Active Metabolites to Investigate Complex CYP3A4 Drug-Drug Interaction Potential: A Case Example of Midostaurin.
Drug Metab Dispos
; 46(2): 109-121, 2018 02.
Article
in English
| MEDLINE | ID: mdl-29117990
4.
Midostaurin, a Novel Protein Kinase Inhibitor for the Treatment of Acute Myelogenous Leukemia: Insights from Human Absorption, Metabolism, and Excretion Studies of a BDDCS II Drug.
Drug Metab Dispos
; 45(5): 540-555, 2017 05.
Article
in English
| MEDLINE | ID: mdl-28270565
5.
Physiologically Based Pharmacokinetic Model Predictions of Panobinostat (LBH589) as a Victim and Perpetrator of Drug-Drug Interactions.
Drug Metab Dispos
; 45(12): 1304-1316, 2017 12.
Article
in English
| MEDLINE | ID: mdl-28912253
6.
Clinical disposition, metabolism and in vitro drug-drug interaction properties of omadacycline.
Xenobiotica
; 47(8): 682-696, 2017 Aug.
Article
in English
| MEDLINE | ID: mdl-27499331
7.
Antiviral Nucleotide Incorporation by Recombinant Human Mitochondrial RNA Polymerase Is Predictive of Increased In Vivo Mitochondrial Toxicity Risk.
Antimicrob Agents Chemother
; 60(12): 7077-7085, 2016 12.
Article
in English
| MEDLINE | ID: mdl-27645237
8.
Identification of Three Novel Ring Expansion Metabolites of KAE609, a New Spiroindolone Agent for the Treatment of Malaria, in Rats, Dogs, and Humans.
Drug Metab Dispos
; 44(5): 653-64, 2016 May.
Article
in English
| MEDLINE | ID: mdl-26921386
9.
Disposition and metabolism of [(14)C] Sacubitril/Valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects.
Xenobiotica
; 46(11): 986-1000, 2016 Nov.
Article
in English
| MEDLINE | ID: mdl-26931777
10.
Midostaurin drug interaction profile: a comprehensive assessment of CYP3A, CYP2B6, and CYP2C8 drug substrates, and oral contraceptives in healthy participants.
Cancer Chemother Pharmacol
; 93(5): 439-453, 2024 May.
Article
in English
| MEDLINE | ID: mdl-38270613
11.
Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.
Antimicrob Agents Chemother
; 54(7): 2932-9, 2010 Jul.
Article
in English
| MEDLINE | ID: mdl-20457821
12.
Absorption, metabolism, and excretion of [14C]vildagliptin, a novel dipeptidyl peptidase 4 inhibitor, in humans.
Drug Metab Dispos
; 37(3): 536-44, 2009 Mar.
Article
in English
| MEDLINE | ID: mdl-19074975
13.
Correction to: Midostaurin drug interaction profile: a comprehensive assessment of CYP3A, CYP2B6, and CYP2C8 drug substrates, and oral contraceptives in healthy participants.
Cancer Chemother Pharmacol
; 2024 Mar 05.
Article
in English
| MEDLINE | ID: mdl-38438807
14.
Estimation of fractions metabolized by hepatic CYP enzymes using a concept of inter-system extrapolation factors (ISEFs) - a comparison with the chemical inhibition method.
Drug Metab Pers Ther
; 32(4): 191-200, 2017 Dec 20.
Article
in English
| MEDLINE | ID: mdl-29176011
15.
Drug Interaction Potential of Osilodrostat (LCI699) Based on Its Effect on the Pharmacokinetics of Probe Drugs of Cytochrome P450 Enzymes in Healthy Adults.
Clin Drug Investig
; 37(5): 465-472, 2017 May.
Article
in English
| MEDLINE | ID: mdl-28155129
16.
Physiologically based pharmacokinetic modeling for assessing the clinical drug-drug interaction of alisporivir.
Eur J Pharm Sci
; 63: 103-12, 2014 Oct 15.
Article
in English
| MEDLINE | ID: mdl-25008118
17.
Time-dependent inhibition and induction of human cytochrome P4503A4/5 by an oral IAP antagonist, LCL161, in vitro and in vivo in healthy subjects.
J Clin Pharmacol
; 53(6): 642-53, 2013 Jun.
Article
in English
| MEDLINE | ID: mdl-23585187
18.
Pharmacokinetics and metabolism of lumiracoxib in healthy male subjects.
Drug Metab Dispos
; 32(5): 566-71, 2004 May.
Article
in English
| MEDLINE | ID: mdl-15100180
19.
N-alkyl urea hydroxamic acids as a new class of peptide deformylase inhibitors with antibacterial activity.
Antimicrob Agents Chemother
; 46(9): 2752-64, 2002 Sep.
Article
in English
| MEDLINE | ID: mdl-12183225
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