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1.
Comparative Analysis of the Physiological and Transport Functions of Various Sources of Renal Proximal Tubule Cells Under Static and Fluidic Conditions in PhysioMimix{trade mark, serif} T12 Platform.
Drug Metab Dispos
; 2024 Apr 16.
Article
in English
| MEDLINE | ID: mdl-38626992
2.
An in vitro-in silico workflow for predicting renal clearance of PFAS.
Toxicol Appl Pharmacol
; : 117015, 2024 Jun 23.
Article
in English
| MEDLINE | ID: mdl-38917890
3.
Incorporating microglia-like cells in human induced pluripotent stem cell-derived retinal organoids.
J Cell Mol Med
; 27(3): 435-445, 2023 02.
Article
in English
| MEDLINE | ID: mdl-36644817
4.
An innovative study design with intermittent dosing to generate a GLP-regulatory package in preclinical species for long lasting molecule M5717, inhibitor of Plasmodium eukaryotic translation elongation factor 2.
Toxicol Appl Pharmacol
; 443: 116006, 2022 05 15.
Article
in English
| MEDLINE | ID: mdl-35367236
5.
Deconvolution of Cytochrome P450 Induction Mechanisms in HepaRG Nuclear Hormone Receptor Knockout Cells.
Drug Metab Dispos
; 49(8): 668-678, 2021 08.
Article
in English
| MEDLINE | ID: mdl-34035124
6.
Human-Induced Pluripotent Stem Cells Generate Light Responsive Retinal Organoids with Variable and Nutrient-Dependent Efficiency.
Stem Cells
; 36(10): 1535-1551, 2018 10.
Article
in English
| MEDLINE | ID: mdl-30004612
7.
A multicenter assessment of single-cell models aligned to standard measures of cell health for prediction of acute hepatotoxicity.
Arch Toxicol
; 91(3): 1385-1400, 2017 Mar.
Article
in English
| MEDLINE | ID: mdl-27344343
8.
Nephron Toxicity Profiling via Untargeted Metabolome Analysis Employing a High Performance Liquid Chromatography-Mass Spectrometry-based Experimental and Computational Pipeline.
J Biol Chem
; 290(31): 19121-32, 2015 Jul 31.
Article
in English
| MEDLINE | ID: mdl-26055719
9.
Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man.
Arch Toxicol
; 90(12): 2979-3003, 2016 Dec.
Article
in English
| MEDLINE | ID: mdl-27659300
10.
Interleukin-19 as a translational indicator of renal injury.
Arch Toxicol
; 89(1): 101-6, 2015 Jan.
Article
in English
| MEDLINE | ID: mdl-24714768
11.
IL-2-mediated hepatotoxicity: knowledge gap identification based on the irAOP concept.
J Immunotoxicol
; 21(1): 2332177, 2024 Dec.
Article
in English
| MEDLINE | ID: mdl-38578203
12.
Transcriptomic hepatotoxicity signature of chlorpromazine after short- and long-term exposure in primary human sandwich cultures.
Drug Metab Dispos
; 41(10): 1835-42, 2013 Oct.
Article
in English
| MEDLINE | ID: mdl-23913027
13.
Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME.
Arch Toxicol
; 87(8): 1315-530, 2013 Aug.
Article
in English
| MEDLINE | ID: mdl-23974980
14.
Immuno-inflammatory in vitro hepatotoxicity models to assess side effects of biologicals exemplified by aldesleukin.
Front Immunol
; 14: 1275368, 2023.
Article
in English
| MEDLINE | ID: mdl-38045689
15.
The evolving role of investigative toxicology in the pharmaceutical industry.
Nat Rev Drug Discov
; 22(4): 317-335, 2023 04.
Article
in English
| MEDLINE | ID: mdl-36781957
16.
Reproducibility and Robustness of a Liver Microphysiological System PhysioMimix LC12 under Varying Culture Conditions and Cell Type Combinations.
Bioengineering (Basel)
; 10(10)2023 Oct 14.
Article
in English
| MEDLINE | ID: mdl-37892925
17.
Considerations from an International Regulatory and Pharmaceutical Industry (IQ MPS Affiliate) Workshop on the Standardization of Complex In Vitro Models in Drug Development.
Adv Biol (Weinh)
; : e2300131, 2023 Oct 09.
Article
in English
| MEDLINE | ID: mdl-37814378
18.
Evaluation of novel acute urinary rat kidney toxicity biomarker for subacute toxicity studies in preclinical trials.
Toxicol Pathol
; 40(7): 1031-48, 2012 Oct.
Article
in English
| MEDLINE | ID: mdl-22581810
19.
Analysis of reproducibility and robustness of OrganoPlate® 2-lane 96, a liver microphysiological system for studies of pharmacokinetics and toxicological assessment of drugs.
Toxicol In Vitro
; 85: 105464, 2022 Dec.
Article
in English
| MEDLINE | ID: mdl-36057418
20.
Human Retinal Organoids Provide a Suitable Tool for Toxicological Investigations: A Comprehensive Validation Using Drugs and Compounds Affecting the Retina.
Stem Cells Transl Med
; 11(2): 159-177, 2022 03 17.
Article
in English
| MEDLINE | ID: mdl-35298655