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1.
Quantitative assessment of coat-hanger ribs detected on three-dimensional ultrasound for prenatal diagnosis of Kagami-Ogata syndrome.
J Obstet Gynaecol Res
; 48(12): 3314-3318, 2022 Dec.
Article
in English
| MEDLINE | ID: mdl-36087043
2.
Prediction of Oral Pharmacokinetics Using a Combination of In Silico Descriptors and In Vitro ADME Properties.
Mol Pharm
; 18(3): 1071-1079, 2021 03 01.
Article
in English
| MEDLINE | ID: mdl-33512165
3.
Characterization of plasma protein binding in two mouse models of humanized liver, PXB mouse and humanized TK-NOG mouse.
Xenobiotica
; 51(1): 51-60, 2021 Jan.
Article
in English
| MEDLINE | ID: mdl-32779988
4.
Direct Comparison of Total Clearance Prediction: Computational Machine Learning Model versus Bottom-Up Approach Using In Vitro Assay.
Mol Pharm
; 17(7): 2299-2309, 2020 07 06.
Article
in English
| MEDLINE | ID: mdl-32478525
5.
Direct Drug Delivery of Low-Permeable Compounds to the Central Nervous System Via Intranasal Administration in Rats and Monkeys.
Pharm Res
; 36(5): 76, 2019 Apr 01.
Article
in English
| MEDLINE | ID: mdl-30937626
6.
Prediction of human pharmacokinetics of long half-life compounds using chimeric mice with humanised liver.
Xenobiotica
; 49(12): 1379-1387, 2019 Dec.
Article
in English
| MEDLINE | ID: mdl-30744481
7.
Application of unbound liver-to-plasma concentration ratio to quantitative projection of cytochrome P450-mediated drug-drug interactions using physiologically based pharmacokinetic modelling approach.
Xenobiotica
; 49(11): 1251-1259, 2019 Nov.
Article
in English
| MEDLINE | ID: mdl-30516093
8.
Impact of P-Glycoprotein on Intestinal Absorption of an Inhibitor of Apoptosis Protein Antagonist in Rats: Mechanisms of Nonlinear Pharmacokinetics and Food Effects.
Pharm Res
; 35(10): 190, 2018 Aug 13.
Article
in English
| MEDLINE | ID: mdl-30105478
9.
Discovery of 1,2,3,4-tetrahydropyrimido[1,2-a]benzimidazoles as novel class of corticotropin releasing factor 1 receptor antagonists.
Bioorg Med Chem
; 26(9): 2229-2250, 2018 05 15.
Article
in English
| MEDLINE | ID: mdl-29459145
10.
Discovery of 4-chloro-2-(2,4-dichloro-6-methylphenoxy)-1-methyl-7-(pentan-3-yl)-1H-benzimidazole, a novel CRF1 receptor antagonist.
Bioorg Med Chem
; 25(5): 1556-1570, 2017 03 01.
Article
in English
| MEDLINE | ID: mdl-28174066
11.
Species differences and substrate specificity of CYP3A heteroactivation by efavirenz.
Xenobiotica
; 45(4): 345-52, 2015 Apr.
Article
in English
| MEDLINE | ID: mdl-25387130
12.
Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors.
Bioorg Med Chem
; 22(4): 1468-78, 2014 Feb 15.
Article
in English
| MEDLINE | ID: mdl-24440478
13.
Risk assessment of drug-drug interactions using hepatocytes suspended in serum during the drug discovery process.
Xenobiotica
; 44(4): 336-44, 2014 Apr.
Article
in English
| MEDLINE | ID: mdl-24074236
14.
Design, synthesis, and biological activities of novel hexahydropyrazino[1,2-a]indole derivatives as potent inhibitors of apoptosis (IAP) proteins antagonists with improved membrane permeability across MDR1 expressing cells.
Bioorg Med Chem
; 21(24): 7938-54, 2013 Dec 15.
Article
in English
| MEDLINE | ID: mdl-24169315
15.
Human Brain Penetration Prediction Using Scaling Approach from Animal Machine Learning Models.
AAPS J
; 25(5): 86, 2023 09 05.
Article
in English
| MEDLINE | ID: mdl-37667061
16.
Quantitation and characterization of glucosylsphingosine in cerebrospinal fluid (CSF), plasma, and brain of monkey model with Gaucher disease.
Drug Metab Pharmacokinet
; 53: 100530, 2023 Dec.
Article
in English
| MEDLINE | ID: mdl-37924723
17.
Ensemble Machine Learning Approaches Based on Molecular Descriptors and Graph Convolutional Networks for Predicting the Efflux Activities of MDR1 and BCRP Transporters.
AAPS J
; 25(5): 88, 2023 09 12.
Article
in English
| MEDLINE | ID: mdl-37700207
18.
Evaluation of cytochrome P450-mediated drug-drug interactions based on the strategies recommended by regulatory authorities.
Xenobiotica
; 42(2): 127-38, 2012 Feb.
Article
in English
| MEDLINE | ID: mdl-22117526
19.
Highly-sensitive simultaneous quantitation of glucosylsphingosine and galactosylsphingosine in human cerebrospinal fluid by liquid chromatography/tandem mass spectrometry.
J Pharm Biomed Anal
; 217: 114852, 2022 Aug 05.
Article
in English
| MEDLINE | ID: mdl-35636011
20.
Translational CNS Steady-State Drug Disposition Model in Rats, Monkeys, and Humans for Quantitative Prediction of Brain-to-Plasma and Cerebrospinal Fluid-to-Plasma Unbound Concentration Ratios.
AAPS J
; 23(4): 81, 2021 06 03.
Article
in English
| MEDLINE | ID: mdl-34085128