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1.
The Nonclinical Disposition and Pharmacokinetic/Pharmacodynamic Properties of N-Acetylgalactosamine-Conjugated Small Interfering RNA Are Highly Predictable and Build Confidence in Translation to Human.
Drug Metab Dispos
; 50(6): 781-797, 2022 06.
Article
in English
| MEDLINE | ID: mdl-34154993
2.
Inhibition of cell adhesion by anti-P-selectin aptamer: a new potential therapeutic agent for sickle cell disease.
Blood
; 117(2): 727-35, 2011 Jan 13.
Article
in English
| MEDLINE | ID: mdl-20926770
3.
Aptamer ARC19499 mediates a procoagulant hemostatic effect by inhibiting tissue factor pathway inhibitor.
Blood
; 117(20): 5514-22, 2011 May 19.
Article
in English
| MEDLINE | ID: mdl-21389323
4.
Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates.
Nat Biotechnol
; 40(10): 1500-1508, 2022 10.
Article
in English
| MEDLINE | ID: mdl-35654979
5.
Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet-derived growth factor B by selective aptamer AX102.
Cancer Res
; 67(15): 7358-67, 2007 Aug 01.
Article
in English
| MEDLINE | ID: mdl-17671206
6.
Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics.
MAbs
; 10(2): 244-255, 2018.
Article
in English
| MEDLINE | ID: mdl-29271699
7.
Direct in vitro selection of a 2'-O-methyl aptamer to VEGF.
Chem Biol
; 12(1): 25-33, 2005 Jan.
Article
in English
| MEDLINE | ID: mdl-15664512
8.
Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies.
MAbs
; 8(6): 1064-78, 2016.
Article
in English
| MEDLINE | ID: mdl-27232760
9.
ADP-specific sensors enable universal assay of protein kinase activity.
Chem Biol
; 11(4): 499-508, 2004 Apr.
Article
in English
| MEDLINE | ID: mdl-15123244
10.
Protein-precursor tRNA contact leads to sequence-specific recognition of 5' leaders by bacterial ribonuclease P.
J Mol Biol
; 396(1): 195-208, 2010 Feb 12.
Article
in English
| MEDLINE | ID: mdl-19932118
11.
Pharmacologic and pharmacokinetic assessment of anti-TGFbeta2 aptamers in rabbit plasma and aqueous humor.
Pharm Res
; 23(2): 303-11, 2006 Feb.
Article
in English
| MEDLINE | ID: mdl-16411148
12.
The affinity of magnesium binding sites in the Bacillus subtilis RNase P x pre-tRNA complex is enhanced by the protein subunit.
Biochemistry
; 41(30): 9545-58, 2002 Jul 30.
Article
in English
| MEDLINE | ID: mdl-12135377
13.
Specific phosphorothioate substitutions probe the active site of Bacillus subtilis ribonuclease P.
RNA
; 8(7): 933-47, 2002 Jul.
Article
in English
| MEDLINE | ID: mdl-12166648
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