Search | VHL CLAP/WR-PAHO/WHO

1.

Blocking HbS Polymerization in SCD.

Lettre, Guillaume.

Cell ; 180(5): 819, 2020 03 05.

Article in English | MEDLINE | ID: mdl-32142671

2.

Multimodal CRISPR perturbations of GWAS loci associated with coronary artery disease in vascular endothelial cells.

Wünnemann, Florian; Fotsing Tadjo, Thierry; Beaudoin, Mélissa; Lalonde, Simon; Lo, Ken Sin; Kleinstiver, Benjamin P; Lettre, Guillaume.

PLoS Genet ; 19(3): e1010680, 2023 03.

Article in English | MEDLINE | ID: mdl-36928188

3.

Transcriptome-wide association study in UK Biobank Europeans identifies associations with blood cell traits.

Rowland, Bryce; Venkatesh, Sanan; Tardaguila, Manuel; Wen, Jia; Rosen, Jonathan D; Tapia, Amanda L; Sun, Quan; Graff, Mariaelisa; Vuckovic, Dragana; Lettre, Guillaume; Sankaran, Vijay G; Voloudakis, Georgios; Roussos, Panos; Huffman, Jennifer E; Reiner, Alexander P; Soranzo, Nicole; Raffield, Laura M; Li, Yun.

Hum Mol Genet ; 31(14): 2333-2347, 2022 07 21.

Article in English | MEDLINE | ID: mdl-35138379

4.

Variation and impact of polygenic hematologic traits in monogenic sickle cell disease.

Pincez, Thomas; Lo, Ken Sin; D'Orengiani, Anne-Laure Pham Hung d'Alexandry; Garrett, Melanie E; Brugnara, Carlo; Ashley-Koch, Allison E; Telen, Marilyn J; Galacteros, Frederic; Joly, Philippe; Bartolucci, Pablo; Lettre, Guillaume.

Haematologica ; 108(3): 870-881, 2023 03 01.

Article in English | MEDLINE | ID: mdl-36226494

5.

Importance of genetic testing in unexplained cardiac arrest.

Grondin, Steffany; Davies, Brianna; Cadrin-Tourigny, Julia; Steinberg, Christian; Cheung, Christopher C; Jorda, Paloma; Healey, Jeffrey S; Green, Martin S; Sanatani, Shubhayan; Alqarawi, Wael; Angaran, Paul; Arbour, Laura; Antiperovitch, Pavel; Khan, Habib; Leather, Richard; Guerra, Peter G; Rivard, Lena; Simpson, Christopher S; Gardner, Martin; MacIntyre, Ciorsti; Seifer, Colette; Fournier, Anne; Joza, Jacqueline; Gollob, Michael H; Lettre, Guillaume; Talajic, Mario; Laksman, Zachary W; Roberts, Jason D; Krahn, Andrew D; Tadros, Rafik.

Eur Heart J ; 43(32): 3071-3081, 2022 08 21.

Article in English | MEDLINE | ID: mdl-35352813

6.

Motif-Raptor: a cell type-specific and transcription factor centric approach for post-GWAS prioritization of causal regulators.

Yao, Qiuming; Ferragina, Paolo; Reshef, Yakir; Lettre, Guillaume; Bauer, Daniel E; Pinello, Luca.

Bioinformatics ; 37(15): 2103-2111, 2021 Aug 09.

Article in English | MEDLINE | ID: mdl-33532840

7.

Pleiotropic effects for Parkin and LRRK2 in leprosy type-1 reactions and Parkinson's disease.

Fava, Vinicius M; Xu, Yong Zhong; Lettre, Guillaume; Van Thuc, Nguyen; Orlova, Marianna; Thai, Vu Hong; Tao, Shao; Croteau, Nathalie; Eldeeb, Mohamed A; MacDougall, Emma J; Cambri, Geison; Lahiri, Ramanuj; Adams, Linda; Fon, Edward A; Trempe, Jean-François; Cobat, Aurélie; Alcaïs, Alexandre; Abel, Laurent; Schurr, Erwin.

Proc Natl Acad Sci U S A ; 116(31): 15616-15624, 2019 07 30.

Article in English | MEDLINE | ID: mdl-31308240

8.

Multi-ethnic genome-wide association analyses of white blood cell and platelet traits in the Population Architecture using Genomics and Epidemiology (PAGE) study.

Hu, Yao; Bien, Stephanie A; Nishimura, Katherine K; Haessler, Jeffrey; Hodonsky, Chani J; Baldassari, Antoine R; Highland, Heather M; Wang, Zhe; Preuss, Michael; Sitlani, Colleen M; Wojcik, Genevieve L; Tao, Ran; Graff, Mariaelisa; Huckins, Laura M; Sun, Quan; Chen, Ming-Huei; Mousas, Abdou; Auer, Paul L; Lettre, Guillaume; Tang, Weihong; Qi, Lihong; Thyagarajan, Bharat; Buyske, Steve; Fornage, Myriam; Hindorff, Lucia A; Li, Yun; Lin, Danyu; Reiner, Alexander P; North, Kari E; Loos, Ruth J F; Raffield, Laura M; Peters, Ulrike; Avery, Christy L; Kooperberg, Charles.

BMC Genomics ; 22(1): 432, 2021 Jun 09.

Article in English | MEDLINE | ID: mdl-34107879

9.

Whole genome sequence association with E-selectin levels reveals loss-of-function variant in African Americans.

Polfus, Linda M; Raffield, Laura M; Wheeler, Marsha M; Tracy, Russell P; Lange, Leslie A; Lettre, Guillaume; Miller, Amanda; Correa, Adolfo; Bowler, Russell P; Bis, Joshua C; Salimi, Shabnam; Jenny, Nancy Swords; Pankratz, Nathan; Wang, Biqi; Preuss, Michael H; Zhou, Lisheng; Moscati, Arden; Nadkarni, Girish N; Loos, Ruth J F; Zhong, Xue; Li, Bingshan; Johnsen, Jill M; Nickerson, Deborah A; Reiner, Alex P; Auer, Paul L.

Hum Mol Genet ; 28(3): 515-523, 2019 02 01.

Article in English | MEDLINE | ID: mdl-30307499

10.

Potential causal role of l-glutamine in sickle cell disease painful crises: A Mendelian randomization analysis.

Ilboudo, Yann; Garrett, Melanie E; Bartolucci, Pablo; Brugnara, Carlo; Clish, Clary B; Hirschhorn, Joel N; Galactéros, Frédéric; Ashley-Koch, Allison E; Telen, Marilyn J; Lettre, Guillaume.

Blood Cells Mol Dis ; 86: 102504, 2021 02.

Article in English | MEDLINE | ID: mdl-32949984

11.

Common α-globin variants modify hematologic and other clinical phenotypes in sickle cell trait and disease.

Raffield, Laura M; Ulirsch, Jacob C; Naik, Rakhi P; Lessard, Samuel; Handsaker, Robert E; Jain, Deepti; Kang, Hyun M; Pankratz, Nathan; Auer, Paul L; Bao, Erik L; Smith, Joshua D; Lange, Leslie A; Lange, Ethan M; Li, Yun; Thornton, Timothy A; Young, Bessie A; Abecasis, Goncalo R; Laurie, Cathy C; Nickerson, Deborah A; McCarroll, Steven A; Correa, Adolfo; Wilson, James G; Lettre, Guillaume; Sankaran, Vijay G; Reiner, Alex P.

PLoS Genet ; 14(3): e1007293, 2018 03.

Article in English | MEDLINE | ID: mdl-29590102

12.

14q32 and let-7 microRNAs regulate transcriptional networks in fetal and adult human erythroblasts.

Lessard, Samuel; Beaudoin, Mélissa; Orkin, Stuart H; Bauer, Daniel E; Lettre, Guillaume.

Hum Mol Genet ; 27(8): 1411-1420, 2018 04 15.

Article in English | MEDLINE | ID: mdl-29432581

13.

Human genetic variation alters CRISPR-Cas9 on- and off-targeting specificity at therapeutically implicated loci.

Lessard, Samuel; Francioli, Laurent; Alfoldi, Jessica; Tardif, Jean-Claude; Ellinor, Patrick T; MacArthur, Daniel G; Lettre, Guillaume; Orkin, Stuart H; Canver, Matthew C.

Proc Natl Acad Sci U S A ; 114(52): E11257-E11266, 2017 12 26.

Article in English | MEDLINE | ID: mdl-29229813

14.

Rare coding variants pinpoint genes that control human hematological traits.

Mousas, Abdou; Ntritsos, Georgios; Chen, Ming-Huei; Song, Ci; Huffman, Jennifer E; Tzoulaki, Ioanna; Elliott, Paul; Psaty, Bruce M; Auer, Paul L; Johnson, Andrew D; Evangelou, Evangelos; Lettre, Guillaume; Reiner, Alexander P.

PLoS Genet ; 13(8): e1006925, 2017 Aug.

Article in English | MEDLINE | ID: mdl-28787443

15.

Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis.

Polfus, Linda M; Khajuria, Rajiv K; Schick, Ursula M; Pankratz, Nathan; Pazoki, Raha; Brody, Jennifer A; Chen, Ming-Huei; Auer, Paul L; Floyd, James S; Huang, Jie; Lange, Leslie; van Rooij, Frank J A; Gibbs, Richard A; Metcalf, Ginger; Muzny, Donna; Veeraraghavan, Narayanan; Walter, Klaudia; Chen, Lu; Yanek, Lisa; Becker, Lewis C; Peloso, Gina M; Wakabayashi, Aoi; Kals, Mart; Metspalu, Andres; Esko, Tõnu; Fox, Keolu; Wallace, Robert; Franceschini, Nora; Matijevic, Nena; Rice, Kenneth M; Bartz, Traci M; Lyytikäinen, Leo-Pekka; Kähönen, Mika; Lehtimäki, Terho; Raitakari, Olli T; Li-Gao, Ruifang; Mook-Kanamori, Dennis O; Lettre, Guillaume; van Duijn, Cornelia M; Franco, Oscar H; Rich, Stephen S; Rivadeneira, Fernando; Hofman, Albert; Uitterlinden, André G; Wilson, James G; Psaty, Bruce M; Soranzo, Nicole; Dehghan, Abbas; Boerwinkle, Eric; Zhang, Xiaoling.

Am J Hum Genet ; 99(2): 481-8, 2016 08 04.

Article in English | MEDLINE | ID: mdl-27486782

16.

Testing the role of predicted gene knockouts in human anthropometric trait variation.

Lessard, Samuel; Manning, Alisa K; Low-Kam, Cécile; Auer, Paul L; Giri, Ayush; Graff, Mariaelisa; Schurmann, Claudia; Yaghootkar, Hanieh; Luan, Jian'an; Esko, Tonu; Karaderi, Tugce; Bottinger, Erwin P; Lu, Yingchang; Carlson, Chris; Caulfield, Mark; Dubé, Marie-Pierre; Jackson, Rebecca D; Kooperberg, Charles; McKnight, Barbara; Mongrain, Ian; Peters, Ulrike; Reiner, Alex P; Rhainds, David; Sotoodehnia, Nona; Hirschhorn, Joel N; Scott, Robert A; Munroe, Patricia B; Frayling, Timothy M; Loos, Ruth J F; North, Kari E; Edwards, Todd L; Tardif, Jean-Claude; Lindgren, Cecilia M; Lettre, Guillaume.

Hum Mol Genet ; 25(10): 2082-2092, 2016 05 15.

Article in English | MEDLINE | ID: mdl-26908616

17.

PHACTR1 splicing isoforms and eQTLs in atherosclerosis-relevant human cells.

Codina-Fauteux, Valérie-Anne; Beaudoin, Mélissa; Lalonde, Simon; Lo, Ken Sin; Lettre, Guillaume.

BMC Med Genet ; 19(1): 97, 2018 06 08.

Article in English | MEDLINE | ID: mdl-29884117

18.

Clonal hematopoiesis in sickle cell disease.

Pincez, Thomas; Lee, Simon S K; Ilboudo, Yann; Preuss, Michael; Pham Hung d'Alexandry d'Orengiani, Anne-Laure; Bartolucci, Pablo; Galactéros, Frédéric; Joly, Philippe; Bauer, Daniel E; Loos, Ruth J F; Lindsley, R Coleman; Lettre, Guillaume.

Blood ; 138(21): 2148-2152, 2021 11 25.

Article in English | MEDLINE | ID: mdl-34521115

19.

Re-assessing the effect of fetal hemoglobin on stroke in the Cooperative Study of Sickle Cell Disease.

Pincez, Thomas; Lettre, Guillaume.

Am J Hematol ; 98(11): E309-E311, 2023 11.

Article in English | MEDLINE | ID: mdl-37552626

20.

The genetics of platelet count and volume in humans.

Eicher, John D; Lettre, Guillaume; Johnson, Andrew D.

Platelets ; 29(2): 125-130, 2018 Mar.

Article in English | MEDLINE | ID: mdl-28649937

VHL CLAP/WR-PAHO/WHO

Latin-American Center for Perinatology, Woman and Reproductive Health

Config filters

Your selection (0)

Export format:

Export: