Search | VHL CLAP/WR-PAHO/WHO

1.

Human antibody C10 neutralizes by diminishing Zika but enhancing dengue virus dynamics.

Lim, Xin-Xiang; Shu, Bo; Zhang, Shuijun; Tan, Aaron W K; Ng, Thiam-Seng; Lim, Xin-Ni; Chew, Valerie S-Y; Shi, Jian; Screaton, Gavin R; Lok, Shee-Mei; Anand, Ganesh S.

Cell ; 184(25): 6067-6080.e13, 2021 12 09.

Article in English | MEDLINE | ID: mdl-34852238

2.

Common Features of Enveloped Viruses and Implications for Immunogen Design for Next-Generation Vaccines.

Rey, Felix A; Lok, Shee-Mei.

Cell ; 172(6): 1319-1334, 2018 03 08.

Article in English | MEDLINE | ID: mdl-29522750

3.

A Human Bi-specific Antibody against Zika Virus with High Therapeutic Potential.

Wang, Jiaqi; Bardelli, Marco; Espinosa, Diego A; Pedotti, Mattia; Ng, Thiam-Seng; Bianchi, Siro; Simonelli, Luca; Lim, Elisa X Y; Foglierini, Mathilde; Zatta, Fabrizia; Jaconi, Stefano; Beltramello, Martina; Cameroni, Elisabetta; Fibriansah, Guntur; Shi, Jian; Barca, Taylor; Pagani, Isabel; Rubio, Alicia; Broccoli, Vania; Vicenzi, Elisa; Graham, Victoria; Pullan, Steven; Dowall, Stuart; Hewson, Roger; Jurt, Simon; Zerbe, Oliver; Stettler, Karin; Lanzavecchia, Antonio; Sallusto, Federica; Cavalli, Andrea; Harris, Eva; Lok, Shee-Mei; Varani, Luca; Corti, Davide.

Cell ; 171(1): 229-241.e15, 2017 Sep 21.

Article in English | MEDLINE | ID: mdl-28938115

4.

Inhibiting EBV: The Key to Carefree Smooching.

Lok, Shee-Mei.

Immunity ; 48(4): 623-625, 2018 04 17.

Article in English | MEDLINE | ID: mdl-29669245

5.

How NS1 Antibodies Prevent Severe Flavivirus Disease.

Ooi, Justin S G; Lok, Shee-Mei.

Trends Biochem Sci ; 46(7): 519-521, 2021 07.

Article in English | MEDLINE | ID: mdl-33895084

6.

Structure and neutralization mechanism of a human antibody targeting a complex Epitope on Zika virus.

Adams, Cameron; Carbaugh, Derek L; Shu, Bo; Ng, Thiam-Seng; Castillo, Izabella N; Bhowmik, Ryan; Segovia-Chumbez, Bruno; Puhl, Ana C; Graham, Stephen; Diehl, Sean A; Lazear, Helen M; Lok, Shee-Mei; de Silva, Aravinda M; Premkumar, Lakshmanane.

PLoS Pathog ; 19(1): e1010814, 2023 Jan.

Article in English | MEDLINE | ID: mdl-36626401

7.

Flat-lying antibody prevents disease enhancement.

Lok, Shee-Mei.

Nat Immunol ; 19(11): 1150-1152, 2018 11.

Article in English | MEDLINE | ID: mdl-30323339

8.

Antibody affinity versus dengue morphology influences neutralization.

Fibriansah, Guntur; Lim, Elisa X Y; Marzinek, Jan K; Ng, Thiam-Seng; Tan, Joanne L; Huber, Roland G; Lim, Xin-Ni; Chew, Valerie S Y; Kostyuchenko, Victor A; Shi, Jian; Anand, Ganesh S; Bond, Peter J; Crowe, James E; Lok, Shee-Mei.

PLoS Pathog ; 17(2): e1009331, 2021 02.

Article in English | MEDLINE | ID: mdl-33621239

9.

Structural basis of Chikungunya virus inhibition by monoclonal antibodies.

Zhou, Qun Fei; Fox, Julie M; Earnest, James T; Ng, Thiam-Seng; Kim, Arthur S; Fibriansah, Guntur; Kostyuchenko, Victor A; Shi, Jian; Shu, Bo; Diamond, Michael S; Lok, Shee-Mei.

Proc Natl Acad Sci U S A ; 117(44): 27637-27645, 2020 11 03.

Article in English | MEDLINE | ID: mdl-33087569

10.

Structure of the thermally stable Zika virus.

Kostyuchenko, Victor A; Lim, Elisa X Y; Zhang, Shuijun; Fibriansah, Guntur; Ng, Thiam-Seng; Ooi, Justin S G; Shi, Jian; Lok, Shee-Mei.

Nature ; 533(7603): 425-8, 2016 05 19.

Article in English | MEDLINE | ID: mdl-27093288

11.

Molecular basis of dengue virus serotype 2 morphological switch from 29°C to 37°C.

Lim, Xin-Ni; Shan, Chao; Marzinek, Jan K; Dong, Hongping; Ng, Thiam Seng; Ooi, Justin S G; Fibriansah, Guntur; Wang, Jiaqi; Verma, Chandra S; Bond, Peter J; Shi, Pei-Yong; Lok, Shee-Mei.

PLoS Pathog ; 15(9): e1007996, 2019 09.

Article in English | MEDLINE | ID: mdl-31536610

12.

CD-loop Extension in Zika Virus Envelope Protein Key for Stability and Pathogenesis.

Gallichotte, Emily N; Dinnon, Kenneth H; Lim, Xin-Ni; Ng, Thiam-Seng; Lim, Elisa X Y; Menachery, Vineet D; Lok, Shee-Mei; Baric, Ralph S.

J Infect Dis ; 216(10): 1196-1204, 2017 12 05.

Article in English | MEDLINE | ID: mdl-28968838

13.

Capsid protein is central to the birth of flavivirus particles.

Tan, Ter Yong; Fibriansah, Guntur; Lok, Shee-Mei.

PLoS Pathog ; 16(5): e1008542, 2020 05.

Article in English | MEDLINE | ID: mdl-32463839

14.

Leukocyte immunoglobulin-like receptor B1 is critical for antibody-dependent dengue.

Chan, Kuan Rong; Ong, Eugenia Z; Tan, Hwee Cheng; Zhang, Summer Li-Xin; Zhang, Qian; Tang, Kin Fai; Kaliaperumal, Nivashini; Lim, Angeline Pei Chiew; Hibberd, Martin L; Chan, Soh Ha; Connolly, John E; Krishnan, Manoj N; Lok, Shee Mei; Hanson, Brendon J; Lin, Chao-Nan; Ooi, Eng Eong.

Proc Natl Acad Sci U S A ; 111(7): 2722-7, 2014 Feb 18.

Article in English | MEDLINE | ID: mdl-24550301

15.

Dengue Virus Infection with Highly Neutralizing Levels of Cross-Reactive Antibodies Causes Acute Lethal Small Intestinal Pathology without a High Level of Viremia in Mice.

Watanabe, Satoru; Chan, Kitti Wing Ki; Wang, Jiaqi; Rivino, Laura; Lok, Shee-Mei; Vasudevan, Subhash G.

J Virol ; 89(11): 5847-61, 2015 Jun.

Article in English | MEDLINE | ID: mdl-25787279

16.

Atomic structure of the 75 MDa extremophile Sulfolobus turreted icosahedral virus determined by CryoEM and X-ray crystallography.

Veesler, David; Ng, Thiam-Seng; Sendamarai, Anoop K; Eilers, Brian J; Lawrence, C Martin; Lok, Shee-Mei; Young, Mark J; Johnson, John E; Fu, Chi-yu.

Proc Natl Acad Sci U S A ; 110(14): 5504-9, 2013 Apr 02.

Article in English | MEDLINE | ID: mdl-23520050

17.

Key roles of the Escherichia coli AhpC C-terminus in assembly and catalysis of alkylhydroperoxide reductase, an enzyme essential for the alleviation of oxidative stress.

Dip, Phat Vinh; Kamariah, Neelagandan; Nartey, Wilson; Beushausen, Claudia; Kostyuchenko, Victor A; Ng, Thiam-Seng; Lok, Shee-Mei; Saw, Wuan Geok; Eisenhaber, Frank; Eisenhaber, Birgit; Grüber, Gerhard.

Biochim Biophys Acta ; 1837(12): 1932-1943, 2014 Dec.

Article in English | MEDLINE | ID: mdl-25193562

18.

Near-atomic resolution cryo-electron microscopic structure of dengue serotype 4 virus.

Kostyuchenko, Victor A; Chew, Pau Ling; Ng, Thiam-Seng; Lok, Shee-Mei.

J Virol ; 88(1): 477-82, 2014 Jan.

Article in English | MEDLINE | ID: mdl-24155405

19.

Structural changes in dengue virus when exposed to a temperature of 37°C.

Fibriansah, Guntur; Ng, Thiam-Seng; Kostyuchenko, Victor A; Lee, Jaime; Lee, Sumarlin; Wang, Jiaqi; Lok, Shee-Mei.

J Virol ; 87(13): 7585-92, 2013 Jul.

Article in English | MEDLINE | ID: mdl-23637405

20.

Immature and mature dengue serotype 1 virus structures provide insight into the maturation process.

Kostyuchenko, Victor A; Zhang, Qian; Tan, Joanne L; Ng, Thiam-Seng; Lok, Shee-Mei.

J Virol ; 87(13): 7700-7, 2013 Jul.

Article in English | MEDLINE | ID: mdl-23637416

VHL CLAP/WR-PAHO/WHO

Latin-American Center for Perinatology, Woman and Reproductive Health

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