Search details
1.
Author Correction: Design of amidobenzimidazole STING receptor agonists with systemic activity.
Nature
; 570(7761): E53, 2019 Jun.
Article
in English
| MEDLINE | ID: mdl-31142845
2.
Design of amidobenzimidazole STING receptor agonists with systemic activity.
Nature
; 564(7736): 439-443, 2018 12.
Article
in English
| MEDLINE | ID: mdl-30405246
3.
RIP3 induces apoptosis independent of pronecrotic kinase activity.
Mol Cell
; 56(4): 481-95, 2014 Nov 20.
Article
in English
| MEDLINE | ID: mdl-25459880
4.
High throughput screening identifies ATP-competitive inhibitors of the NLRP1 inflammasome.
Bioorg Med Chem Lett
; 25(14): 2739-43, 2015 Jul 15.
Article
in English
| MEDLINE | ID: mdl-26022841
5.
Crystal structures of human RIP2 kinase catalytic domain complexed with ATP-competitive inhibitors: Foundations for understanding inhibitor selectivity.
Bioorg Med Chem
; 23(21): 7000-6, 2015 Nov 01.
Article
in English
| MEDLINE | ID: mdl-26455654
6.
Toll-like receptor 3-mediated necrosis via TRIF, RIP3, and MLKL.
J Biol Chem
; 288(43): 31268-79, 2013 Oct 25.
Article
in English
| MEDLINE | ID: mdl-24019532
7.
Overcoming the Pregnane X Receptor Liability: Rational Design to Eliminate PXR-Mediated CYP Induction.
ACS Med Chem Lett
; 12(9): 1396-1404, 2021 Sep 09.
Article
in English
| MEDLINE | ID: mdl-34531948
8.
Understanding Pharmacokinetic Disconnect in Preclinical Species for 4-Aminoquinolines: Consequences of Low Permeability and High P-glycoprotein Efflux Ratio on Rat and Dog Oral Pharmacokinetics.
J Pharm Sci
; 109(10): 3160-3171, 2020 10.
Article
in English
| MEDLINE | ID: mdl-32565354
9.
Correction to Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.
ACS Med Chem Lett
; 11(6): 1353, 2020 Jun 11.
Article
in English
| MEDLINE | ID: mdl-32551024
10.
Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors.
ACS Med Chem Lett
; 10(11): 1518-1523, 2019 Nov 14.
Article
in English
| MEDLINE | ID: mdl-31749904
11.
Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer.
ACS Med Chem Lett
; 10(6): 857-862, 2019 Jun 13.
Article
in English
| MEDLINE | ID: mdl-31223438
12.
Discovery of a First-in-Class Receptor Interacting Protein 2 (RIP2) Kinase Specific Clinical Candidate, 2-((4-(Benzo[d]thiazol-5-ylamino)-6-(tert-butylsulfonyl)quinazolin-7-yl)oxy)ethyl Dihydrogen Phosphate, for the Treatment of Inflammatory Diseases.
J Med Chem
; 62(14): 6482-6494, 2019 07 25.
Article
in English
| MEDLINE | ID: mdl-31265286
13.
N-((1S)-1-{[4-((2S)-2-{[(2,4-dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinary bladder contraction and hyperactivity: Part I.
J Pharmacol Exp Ther
; 326(2): 432-42, 2008 Aug.
Article
in English
| MEDLINE | ID: mdl-18499743
14.
Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel.
ACS Med Chem Lett
; 9(10): 1039-1044, 2018 Oct 11.
Article
in English
| MEDLINE | ID: mdl-30344914
15.
Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases.
J Med Chem
; 60(4): 1247-1261, 2017 02 23.
Article
in English
| MEDLINE | ID: mdl-28151659
16.
Structure activity relationships of 5-, 6-, and 7-methyl-substituted azepan-3-one cathepsin K inhibitors.
J Med Chem
; 49(5): 1597-612, 2006 Mar 09.
Article
in English
| MEDLINE | ID: mdl-16509577
17.
DNA-Encoded Library Screening Identifies Benzo[b][1,4]oxazepin-4-ones as Highly Potent and Monoselective Receptor Interacting Protein 1 Kinase Inhibitors.
J Med Chem
; 59(5): 2163-78, 2016 Mar 10.
Article
in English
| MEDLINE | ID: mdl-26854747
18.
The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase.
J Med Chem
; 59(10): 4867-80, 2016 05 26.
Article
in English
| MEDLINE | ID: mdl-27109867
19.
Azepanone-based inhibitors of human cathepsin L.
J Med Chem
; 48(22): 6870-8, 2005 Nov 03.
Article
in English
| MEDLINE | ID: mdl-16250645
20.
Identification of selective small molecule inhibitors of the nucleotide-binding oligomerization domain 1 (NOD1) signaling pathway.
PLoS One
; 9(5): e96737, 2014.
Article
in English
| MEDLINE | ID: mdl-24806487