Search | VHL CLAP/WR-PAHO/WHO

1.

Nucleosome repositioning in chronic lymphocytic leukemia.

Piroeva, Kristan V; McDonald, Charlotte; Xanthopoulos, Charalampos; Fox, Chelsea; Clarkson, Christopher T; Mallm, Jan-Philipp; Vainshtein, Yevhen; Ruje, Luminita; Klett, Lara C; Stilgenbauer, Stephan; Mertens, Daniel; Kostareli, Efterpi; Rippe, Karsten; Teif, Vladimir B.

Genome Res ; 33(10): 1649-1661, 2023 10.

Article in English | MEDLINE | ID: mdl-37699659

2.

Evaluation of vecabrutinib as a model for noncovalent BTK/ITK inhibition for treatment of chronic lymphocytic leukemia.

Jebaraj, Billy Michael Chelliah; Müller, Annika; Dheenadayalan, Rashmi Priyadharshini; Endres, Sascha; Roessner, Philipp M; Seyfried, Felix; Walliser, Claudia; Wist, Martin; Qi, Jialei; Tausch, Eugen; Mertens, Daniel; Fox, Judith A; Debatin, Klaus-Michael; Meyer, Lüder Hinrich; Taverna, Pietro; Seiffert, Martina; Gierschik, Peter; Stilgenbauer, Stephan.

Blood ; 139(6): 859-875, 2022 02 10.

Article in English | MEDLINE | ID: mdl-34662393

3.

Modeling the B-cell receptor signaling on single cell level reveals a stable network circuit topology between nonmalignant B cells and chronic lymphocytic leukemia cells and between untreated cells and cells treated with kinase inhibitors.

Wolf, Christine; Maus, Carsten; Persicke, Michael R O; Filarsky, Katharina; Tausch, Eugen; Schneider, Christof; Döhner, Hartmut; Stilgenbauer, Stephan; Lichter, Peter; Höfer, Thomas; Mertens, Daniel.

Int J Cancer ; 151(5): 783-796, 2022 09 01.

Article in English | MEDLINE | ID: mdl-35527719

4.

Prognostic and predictive impact of genetic markers in patients with CLL treated with obinutuzumab and venetoclax.

Tausch, Eugen; Schneider, Christof; Robrecht, Sandra; Zhang, Can; Dolnik, Anna; Bloehdorn, Johannes; Bahlo, Jasmin; Al-Sawaf, Othman; Ritgen, Matthias; Fink, Anna-Maria; Eichhorst, Barbara; Kreuzer, Karl-Anton; Tandon, Maneesh; Humphrey, Kathryn; Jiang, Yanwen; Schary, William; Bullinger, Lars; Mertens, Daniel; Lurà, Michele Porro; Kneba, Michael; Döhner, Hartmut; Fischer, Kirsten; Hallek, Michael; Stilgenbauer, Stephan.

Blood ; 135(26): 2402-2412, 2020 06 25.

Article in English | MEDLINE | ID: mdl-32206772

5.

Clonal evolution in chronic lymphocytic leukemia is scant in relapsed but accelerated in refractory cases after chemo(immune) therapy.

Zapatka, Marc; Tausch, Eugen; Öztürk, Selcen; Yosifov, Deyan Yordanov; Seiffert, Martina; Zenz, Thorsten; Schneider, Christof; Blöhdorn, Johannes; Döhner, Hartmut; Mertens, Daniel; Lichter, Peter; Stilgenbauer, Stephan.

Haematologica ; 107(3): 604-614, 2022 03 01.

Article in English | MEDLINE | ID: mdl-33691380

6.

Integrative prognostic models predict long-term survival after immunochemotherapy in chronic lymphocytic leukemia patients.

Bloehdorn, Johannes; Krzykalla, Julia; Holzmann, Karlheinz; Gerhardinger, Andreas; Jebaraj, Billy Michael Chelliah; Bahlo, Jasmin; Humphrey, Kathryn; Tausch, Eugen; Robrecht, Sandra; Mertens, Daniel; Schneider, Christof; Fischer, Kirsten; Hallek, Michael; Döhner, Hartmut; Benner, Axel; Stilgenbauer, Stephan.

Haematologica ; 107(3): 615-624, 2022 03 01.

Article in English | MEDLINE | ID: mdl-33730841

7.

HDAC3 functions as a positive regulator in Notch signal transduction.

Ferrante, Francesca; Giaimo, Benedetto Daniele; Bartkuhn, Marek; Zimmermann, Tobias; Close, Viola; Mertens, Daniel; Nist, Andrea; Stiewe, Thorsten; Meier-Soelch, Johanna; Kracht, Michael; Just, Steffen; Klöble, Patricia; Oswald, Franz; Borggrefe, Tilman.

Nucleic Acids Res ; 48(7): 3496-3512, 2020 04 17.

Article in English | MEDLINE | ID: mdl-32107550

8.

FBXW7 mutations reduce binding of NOTCH1, leading to cleaved NOTCH1 accumulation and target gene activation in CLL.

Close, Viola; Close, William; Kugler, Sabrina Julia; Reichenzeller, Michaela; Yosifov, Deyan Yordanov; Bloehdorn, Johannes; Pan, Leiling; Tausch, Eugen; Westhoff, Mike-Andrew; Döhner, Hartmut; Stilgenbauer, Stephan; Oswald, Franz; Mertens, Daniel.

Blood ; 133(8): 830-839, 2019 02 21.

Article in English | MEDLINE | ID: mdl-30510140

9.

IGF1R as druggable target mediating PI3K-Î´ inhibitor resistance in a murine model of chronic lymphocytic leukemia.

Scheffold, Annika; Jebaraj, Billy Michael Chelliah; Tausch, Eugen; Bloehdorn, Johannes; Ghia, Paolo; Yahiaoui, Anella; Dolnik, Anna; Blätte, Tamara Jacqueline; Bullinger, Lars; Dheenadayalan, Rashmi Priyadharshini; Li, Li; Schneider, Christof; Chen, Shih-Shih; Chiorazzi, Nicholas; Dietrich, Sascha; Seiffert, Martina; Tannheimer, Stacey; Döhner, Hartmut; Mertens, Daniel; Stilgenbauer, Stephan.

Blood ; 134(6): 534-547, 2019 08 08.

Article in English | MEDLINE | ID: mdl-31010847

10.

Mutations driving CLL and their evolution in progression and relapse.

Landau, Dan A; Tausch, Eugen; Taylor-Weiner, Amaro N; Stewart, Chip; Reiter, Johannes G; Bahlo, Jasmin; Kluth, Sandra; Bozic, Ivana; Lawrence, Mike; Böttcher, Sebastian; Carter, Scott L; Cibulskis, Kristian; Mertens, Daniel; Sougnez, Carrie L; Rosenberg, Mara; Hess, Julian M; Edelmann, Jennifer; Kless, Sabrina; Kneba, Michael; Ritgen, Matthias; Fink, Anna; Fischer, Kirsten; Gabriel, Stacey; Lander, Eric S; Nowak, Martin A; Döhner, Hartmut; Hallek, Michael; Neuberg, Donna; Getz, Gad; Stilgenbauer, Stephan; Wu, Catherine J.

Nature ; 526(7574): 525-30, 2015 Oct 22.

Article in English | MEDLINE | ID: mdl-26466571

11.

Linking aberrant chromatin features in chronic lymphocytic leukemia to transcription factor networks.

Mallm, Jan-Philipp; Iskar, Murat; Ishaque, Naveed; Klett, Lara C; Kugler, Sabrina J; Muino, Jose M; Teif, Vladimir B; Poos, Alexandra M; Großmann, Sebastian; Erdel, Fabian; Tavernari, Daniele; Koser, Sandra D; Schumacher, Sabrina; Brors, Benedikt; König, Rainer; Remondini, Daniel; Vingron, Martin; Stilgenbauer, Stephan; Lichter, Peter; Zapatka, Marc; Mertens, Daniel; Rippe, Karsten.

Mol Syst Biol ; 15(5): e8339, 2019 05 22.

Article in English | MEDLINE | ID: mdl-31118277

12.

Prognostic and predictive role of gene mutations in chronic lymphocytic leukemia: results from the pivotal phase III study COMPLEMENT1.

Tausch, Eugen; Beck, Philipp; Schlenk, Richard F; Jebaraj, Billy J; Dolnik, Anna; Yosifov, Deyan Y; Hillmen, Peter; Offner, Fritz; Janssens, Ann; Babu, Govind K; Grosicki, Sebastian; Mayer, Jiri; Panagiotidis, Panagiotis; McKeown, Astrid; Gupta, Ira V; Skorupa, Alexandra; Pallaud, Celine; Bullinger, Lars; Mertens, Daniel; Döhner, Hartmut; Stilgenbauer, Stephan.

Haematologica ; 105(10): 2440-2447, 2020 10 01.

Article in English | MEDLINE | ID: mdl-33054084

13.

Genomic alterations in high-risk chronic lymphocytic leukemia frequently affect cell cycle key regulators and NOTCH1-regulated transcription.

Edelmann, Jennifer; Holzmann, Karlheinz; Tausch, Eugen; Saunderson, Emily A; Jebaraj, Billy M C; Steinbrecher, Daniela; Dolnik, Anna; Blätte, Tamara J; Landau, Dan A; Saub, Jenny; Estenfelder, Sven; Ibach, Stefan; Cymbalista, Florence; Leblond, Veronique; Delmer, Alain; Bahlo, Jasmin; Robrecht, Sandra; Fischer, Kirsten; Goede, Valentin; Bullinger, Lars; Wu, Catherine J; Mertens, Daniel; Ficz, Gabriella; Gribben, John G; Hallek, Michael; Döhner, Hartmut; Stilgenbauer, Stephan.

Haematologica ; 105(5): 1379-1390, 2020 05.

Article in English | MEDLINE | ID: mdl-31467127

14.

NFATC1 activation by DNA hypomethylation in chronic lymphocytic leukemia correlates with clinical staging and can be inhibited by ibrutinib.

Wolf, Christine; Garding, Angela; Filarsky, Katharina; Bahlo, Jasmin; Robrecht, Sandra; Becker, Natalia; Zucknick, Manuela; Rouhi, Arefeh; Weigel, Anja; Claus, Rainer; Weichenhan, Dieter; Eichhorst, Barbara; Fischer, Kirsten; Hallek, Michael; Kuchenbauer, Florian; Plass, Christoph; Döhner, Hartmut; Stilgenbauer, Stephan; Lichter, Peter; Mertens, Daniel.

Int J Cancer ; 142(2): 322-333, 2018 01 15.

Article in English | MEDLINE | ID: mdl-28921505

15.

Triggering T-cell activity in CLL.

Mertens, Daniel; Krönke, Jan.

Blood ; 137(2): 150-151, 2021 01 14.

Article in English | MEDLINE | ID: mdl-33443561

16.

The Phospholipase CÎ³2 Mutants R665W and L845F Identified in Ibrutinib-resistant Chronic Lymphocytic Leukemia Patients Are Hypersensitive to the Rho GTPase Rac2 Protein.

Walliser, Claudia; Hermkes, Elisabeth; Schade, Anja; Wiese, Sebastian; Deinzer, Julia; Zapatka, Marc; Désiré, Laurent; Mertens, Daniel; Stilgenbauer, Stephan; Gierschik, Peter.

J Biol Chem ; 291(42): 22136-22148, 2016 Oct 14.

Article in English | MEDLINE | ID: mdl-27542411

17.

Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial.

Stilgenbauer, Stephan; Schnaiter, Andrea; Paschka, Peter; Zenz, Thorsten; Rossi, Marianna; Döhner, Konstanze; Bühler, Andreas; Böttcher, Sebastian; Ritgen, Matthias; Kneba, Michael; Winkler, Dirk; Tausch, Eugen; Hoth, Patrick; Edelmann, Jennifer; Mertens, Daniel; Bullinger, Lars; Bergmann, Manuela; Kless, Sabrina; Mack, Silja; Jäger, Ulrich; Patten, Nancy; Wu, Lin; Wenger, Michael K; Fingerle-Rowson, Günter; Lichter, Peter; Cazzola, Mario; Wendtner, Clemens M; Fink, Anna M; Fischer, Kirsten; Busch, Raymonde; Hallek, Michael; Döhner, Hartmut.

Blood ; 123(21): 3247-54, 2014 May 22.

Article in English | MEDLINE | ID: mdl-24652989

18.

Epigenetic upregulation of lncRNAs at 13q14.3 in leukemia is linked to the In Cis downregulation of a gene cluster that targets NF-kB.

Garding, Angela; Bhattacharya, Nupur; Claus, Rainer; Ruppel, Melanie; Tschuch, Cordula; Filarsky, Katharina; Idler, Irina; Zucknick, Manuela; Caudron-Herger, Maïwen; Oakes, Christopher; Fleig, Verena; Keklikoglou, Ioanna; Allegra, Danilo; Serra, Leticia; Thakurela, Sudhir; Tiwari, Vijay; Weichenhan, Dieter; Benner, Axel; Radlwimmer, Bernhard; Zentgraf, Hanswalter; Wiemann, Stefan; Rippe, Karsten; Plass, Christoph; Döhner, Hartmut; Lichter, Peter; Stilgenbauer, Stephan; Mertens, Daniel.

PLoS Genet ; 9(4): e1003373, 2013 Apr.

Article in English | MEDLINE | ID: mdl-23593011

19.

Targeting inhibitor of apoptosis proteins by Smac mimetic elicits cell death in poor prognostic subgroups of chronic lymphocytic leukemia.

Opel, Daniela; Schnaiter, Andrea; Dodier, Dagmar; Jovanovic, Marjana; Gerhardinger, Andreas; Idler, Irina; Mertens, Daniel; Bullinger, Lars; Stilgenbauer, Stephan; Fulda, Simone.

Int J Cancer ; 137(12): 2959-70, 2015 Dec 15.

Article in English | MEDLINE | ID: mdl-26096065

20.

Epigenetic silencing of miR-708 enhances NF-κB signaling in chronic lymphocytic leukemia.

Baer, Constance; Oakes, Christopher C; Ruppert, Amy S; Claus, Rainer; Kim-Wanner, Soo-Zin; Mertens, Daniel; Zenz, Thorsten; Stilgenbauer, Stephan; Byrd, John C; Plass, Christoph.

Int J Cancer ; 137(6): 1352-61, 2015 Sep 15.

Article in English | MEDLINE | ID: mdl-25704289

VHL CLAP/WR-PAHO/WHO

Latin-American Center for Perinatology, Woman and Reproductive Health

Config filters

Your selection (0)

Export format:

Export: