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1.
In Vitro and In Vivo Properties of CUO246, a Novel Bacterial DNA Gyrase/Topoisomerase IV Inhibitor.
Antimicrob Agents Chemother
; 66(12): e0092122, 2022 12 20.
Article
in English
| MEDLINE | ID: mdl-36448795
2.
Biased Complement Diversity Selection for Effective Exploration of Chemical Space in Hit-Finding Campaigns.
J Chem Inf Model
; 59(5): 1709-1714, 2019 05 28.
Article
in English
| MEDLINE | ID: mdl-30943027
3.
Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae - Identification of LYS228.
Bioorg Med Chem Lett
; 28(4): 748-755, 2018 02 15.
Article
in English
| MEDLINE | ID: mdl-29336873
4.
Antibacterial activity of enrofloxacin and ciprofloxacin derivatives of ß-octaarginine.
Chem Biodivers
; 12(2): 179-93, 2015 Feb.
Article
in English
| MEDLINE | ID: mdl-25676502
5.
Discovery and Optimization of DNA Gyrase and Topoisomerase IV Inhibitors with Potent Activity against Fluoroquinolone-Resistant Gram-Positive Bacteria.
J Med Chem
; 64(9): 6329-6357, 2021 05 13.
Article
in English
| MEDLINE | ID: mdl-33929852
6.
Synthesis and spectrum of the neoglycoside ACHN-490.
Antimicrob Agents Chemother
; 54(11): 4636-42, 2010 Nov.
Article
in English
| MEDLINE | ID: mdl-20805391
7.
Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria.
J Med Chem
; 63(14): 7773-7816, 2020 07 23.
Article
in English
| MEDLINE | ID: mdl-32634310
8.
Size Matters and How You Measure It: A Gram-Negative Antibacterial Example Exceeding Typical Molecular Weight Limits.
ACS Infect Dis
; 5(10): 1688-1692, 2019 10 11.
Article
in English
| MEDLINE | ID: mdl-31478369
9.
Optimization of LpxC Inhibitors for Antibacterial Activity and Cardiovascular Safety.
ChemMedChem
; 14(16): 1560-1572, 2019 08 20.
Article
in English
| MEDLINE | ID: mdl-31283109
10.
Synthesis and Microbiological Evaluation of Novel Tetracyclic Fluoroquinolones.
ChemMedChem
; 12(20): 1687-1692, 2017 10 20.
Article
in English
| MEDLINE | ID: mdl-28881459
11.
Exploring the active site of the Streptococcus pneumoniae topoisomerase IV-DNA cleavage complex with novel 7,8-bridged fluoroquinolones.
Open Biol
; 6(9)2016 Sep.
Article
in English
| MEDLINE | ID: mdl-27655731
12.
Macrocyclic inhibitors for peptide deformylase: a structure-activity relationship study of the ring size.
J Med Chem
; 47(20): 4941-9, 2004 Sep 23.
Article
in English
| MEDLINE | ID: mdl-15369398
13.
DNA binding ligands with improved in vitro and in vivo potency against drug-resistant Staphylococcus aureus.
J Med Chem
; 47(18): 4352-5, 2004 Aug 26.
Article
in English
| MEDLINE | ID: mdl-15317448
14.
DNA binding ligands targeting drug-resistant bacteria: structure, activity, and pharmacology.
J Med Chem
; 46(18): 3914-29, 2003 Aug 28.
Article
in English
| MEDLINE | ID: mdl-12930152
15.
Dual Recognition of Double-Stranded DNA by 2'-Aminoethoxy-Modified Oligonucleotides.
Angew Chem Int Ed Engl
; 37(9): 1288-1291, 1998 May 18.
Article
in English
| MEDLINE | ID: mdl-29711228
16.
Physicochemical properties of antibacterial compounds: implications for drug discovery.
J Med Chem
; 51(10): 2871-8, 2008 May 22.
Article
in English
| MEDLINE | ID: mdl-18260614
17.
New aminoglycoside antibiotics.
Expert Opin Ther Pat
; 20(10): 1321-41, 2010 Oct.
Article
in English
| MEDLINE | ID: mdl-20670208
18.
Potent and selective xanthine-based inhibitors of phosphodiesterase 5.
Bioorg Med Chem Lett
; 17(8): 2376-9, 2007 Apr 15.
Article
in English
| MEDLINE | ID: mdl-17337182
19.
DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 1: Internal benzimidazole derivatives.
Bioorg Med Chem Lett
; 14(5): 1253-7, 2004 Mar 08.
Article
in English
| MEDLINE | ID: mdl-14980676
20.
DNA binding ligands targeting drug-resistant Gram-positive bacteria. Part 2: C-terminal benzimidazoles and derivatives.
Bioorg Med Chem Lett
; 14(5): 1259-63, 2004 Mar 08.
Article
in English
| MEDLINE | ID: mdl-14980677