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1.
Discovery of MDV6058 (PF-06952229), a selective and potent TGFßR1 inhibitor: Design, synthesis and optimization.
Bioorg Med Chem Lett
; 75: 128979, 2022 11 01.
Article
in English
| MEDLINE | ID: mdl-36089110
2.
Design, synthesis and optimization of bis-amide derivatives as CSF1R inhibitors.
Bioorg Med Chem Lett
; 27(10): 2153-2160, 2017 05 15.
Article
in English
| MEDLINE | ID: mdl-28377059
3.
Structural and biochemical characterization of compounds inhibiting Mycobacterium tuberculosis pantothenate kinase.
J Biol Chem
; 288(25): 18260-70, 2013 Jun 21.
Article
in English
| MEDLINE | ID: mdl-23661699
4.
Optimization of pyrrolamides as mycobacterial GyrB ATPase inhibitors: structure-activity relationship and in vivo efficacy in a mouse model of tuberculosis.
Antimicrob Agents Chemother
; 58(1): 61-70, 2014.
Article
in English
| MEDLINE | ID: mdl-24126580
5.
Assessment of Mycobacterium tuberculosis pantothenate kinase vulnerability through target knockdown and mechanistically diverse inhibitors.
Antimicrob Agents Chemother
; 58(6): 3312-26, 2014 Jun.
Article
in English
| MEDLINE | ID: mdl-24687493
6.
Synthesis and structure activity relationship of imidazo[1,2-a]pyridine-8-carboxamides as a novel antimycobacterial lead series.
Bioorg Med Chem Lett
; 23(17): 4996-5001, 2013 Sep 01.
Article
in English
| MEDLINE | ID: mdl-23867166
7.
Essentiality and functional analysis of type I and type III pantothenate kinases of Mycobacterium tuberculosis.
Microbiology (Reading)
; 156(Pt 9): 2691-2701, 2010 Sep.
Article
in English
| MEDLINE | ID: mdl-20576686
8.
Peptide deformylase inhibitors of Mycobacterium tuberculosis: synthesis, structural investigations, and biological results.
Bioorg Med Chem Lett
; 18(24): 6568-72, 2008 Dec 15.
Article
in English
| MEDLINE | ID: mdl-19008098
9.
Discovery of Imidazo[1,2-a]pyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis.
J Med Chem
; 60(4): 1379-1399, 2017 02 23.
Article
in English
| MEDLINE | ID: mdl-28075132
10.
Pharmacological inhibition of cathepsin K: A promising novel approach for postmenopausal osteoporosis therapy.
Biochem Pharmacol
; 117: 10-9, 2016 10 01.
Article
in English
| MEDLINE | ID: mdl-27106079
11.
Assays, surrogates, and alternative technologies for a TB lead identification program targeting DNA gyrase ATPase.
J Biomol Screen
; 20(2): 265-74, 2015 Feb.
Article
in English
| MEDLINE | ID: mdl-25300873
12.
Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate.
Nat Commun
; 6: 6715, 2015 Mar 31.
Article
in English
| MEDLINE | ID: mdl-25823686
13.
Novel N-linked aminopiperidine-based gyrase inhibitors with improved hERG and in vivo efficacy against Mycobacterium tuberculosis.
J Med Chem
; 57(11): 4889-905, 2014 Jun 12.
Article
in English
| MEDLINE | ID: mdl-24809953
14.
Aminoazabenzimidazoles, a novel class of orally active antimalarial agents.
J Med Chem
; 57(13): 5702-13, 2014 Jul 10.
Article
in English
| MEDLINE | ID: mdl-24914738
15.
Screening, identification, and characterization of mechanistically diverse inhibitors of the Mycobacterium tuberculosis enzyme, pantothenate kinase (CoaA).
J Biomol Screen
; 17(3): 293-302, 2012 Mar.
Article
in English
| MEDLINE | ID: mdl-22086722
16.
Peptide deformylase inhibitors as potent antimycobacterial agents.
Antimicrob Agents Chemother
; 50(11): 3665-73, 2006 Nov.
Article
in English
| MEDLINE | ID: mdl-16966397
17.
Proteins released during high toxin production in Clostridium difficile.
Microbiology (Reading)
; 148(Pt 7): 2245-2253, 2002 Jul.
Article
in English
| MEDLINE | ID: mdl-12101311
18.
Expression of Clostridium difficile toxins A and B and their sigma factor TcdD is controlled by temperature.
Infect Immun
; 71(4): 1784-93, 2003 Apr.
Article
in English
| MEDLINE | ID: mdl-12654792
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