Search details
1.
Indoleamine 2,3-dioxygenase 1 activation in mature cDC1 promotes tolerogenic education of inflammatory cDC2 via metabolic communication.
Immunity
; 55(6): 1032-1050.e14, 2022 06 14.
Article
in English
| MEDLINE | ID: mdl-35704993
2.
De novo NAD+ synthesis enhances mitochondrial function and improves health.
Nature
; 563(7731): 354-359, 2018 11.
Article
in English
| MEDLINE | ID: mdl-30356218
3.
Novel 1,4-Dihydropyridine Derivatives as Mineralocorticoid Receptor Antagonists.
Int J Mol Sci
; 24(3)2023 Jan 26.
Article
in English
| MEDLINE | ID: mdl-36768761
4.
Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration.
Gastroenterology
; 159(3): 956-968.e8, 2020 09.
Article
in English
| MEDLINE | ID: mdl-32485177
5.
Synthesis and biological activity of cyclopropyl Δ7-dafachronic acids as DAF-12 receptor ligands.
Org Biomol Chem
; 19(24): 5403-5412, 2021 06 28.
Article
in English
| MEDLINE | ID: mdl-34056641
6.
Weak Microbial Metabolites: a Treasure Trove for Using Biomimicry to Discover and Optimize Drugs.
Mol Pharmacol
; 98(4): 343-349, 2020 10.
Article
in English
| MEDLINE | ID: mdl-32764096
7.
Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy.
Biochim Biophys Acta
; 1844(10): 1765-72, 2014 Oct.
Article
in English
| MEDLINE | ID: mdl-25062913
8.
Tandem mass spectrometric determination of atypical 3ß-hydroxy-Δ5-bile acids in patients with 3ß-hydroxy-Δ5-C27-steroid oxidoreductase deficiency: application to diagnosis and monitoring of bile acid therapeutic response.
Clin Chem
; 61(7): 955-63, 2015 Jul.
Article
in English
| MEDLINE | ID: mdl-25931455
9.
Poly(ADP-ribose) polymerase inhibition with HYDAMTIQ reduces allergen-induced asthma-like reaction, bronchial hyper-reactivity and airway remodelling.
J Cell Mol Med
; 18(3): 468-79, 2014 Mar.
Article
in English
| MEDLINE | ID: mdl-24444146
10.
Semisynthetic bile acid FXR and TGR5 agonists: physicochemical properties, pharmacokinetics, and metabolism in the rat.
J Pharmacol Exp Ther
; 350(1): 56-68, 2014 Jul.
Article
in English
| MEDLINE | ID: mdl-24784847
11.
Glucuronidation of bile acids under flow conditions: design of experiments and Koenigs-Knorr reaction optimization.
Org Biomol Chem
; 12(47): 9592-600, 2014 Dec 21.
Article
in English
| MEDLINE | ID: mdl-25338931
12.
Discovery and Structure-Activity Relationships of Novel ssDAF-12 Receptor Modulators.
J Med Chem
; 67(5): 4150-4169, 2024 Mar 14.
Article
in English
| MEDLINE | ID: mdl-38417155
13.
Ursodeoxycholic acid attenuates colonic epithelial secretory function.
J Physiol
; 591(9): 2307-18, 2013 May 01.
Article
in English
| MEDLINE | ID: mdl-23507881
14.
Asymmetric synthesis of the four diastereoisomers of a novel non-steroidal farnesoid X receptor (FXR) agonist: role of the chirality on the biological activity.
Bioorg Med Chem
; 21(13): 3780-9, 2013 Jul 01.
Article
in English
| MEDLINE | ID: mdl-23684233
15.
Synthesis and quantitative structure-property relationships of side chain-modified hyodeoxycholic acid derivatives.
Molecules
; 18(9): 10497-513, 2013 Aug 30.
Article
in English
| MEDLINE | ID: mdl-23999724
16.
Chemical exploration of TGR5 functional hot-spots: Synthesis and structure-activity relationships of C7- and C23-Substituted cholic acid derivatives.
Eur J Med Chem
; 261: 115851, 2023 Dec 05.
Article
in English
| MEDLINE | ID: mdl-37813065
17.
Novel pyridine-containing histone deacetylase inhibitors strongly arrest proliferation, induce apoptosis and modulate miRNAs in cancer cells.
Eur J Med Chem
; 247: 115022, 2023 Feb 05.
Article
in English
| MEDLINE | ID: mdl-36549114
18.
Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile salts.
Org Biomol Chem
; 10(20): 4109-15, 2012 May 28.
Article
in English
| MEDLINE | ID: mdl-22517166
19.
Pyrazole[3,4-e][1,4]thiazepin-7-one derivatives as a novel class of Farnesoid X Receptor (FXR) agonists.
Bioorg Med Chem
; 20(11): 3429-45, 2012 Jun 01.
Article
in English
| MEDLINE | ID: mdl-22564381
20.
Structural Basis of Human Dimeric α-Amino-ß-Carboxymuconate-ε-Semialdehyde Decarboxylase Inhibition With TES-1025.
Front Mol Biosci
; 9: 834700, 2022.
Article
in English
| MEDLINE | ID: mdl-35463964