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1.
Pharmacological and genetic activation of cAMP synthesis disrupts cholesterol utilization in Mycobacterium tuberculosis.
PLoS Pathog
; 18(2): e1009862, 2022 02.
Article
in English
| MEDLINE | ID: mdl-35134095
2.
Synthesis and structure-activity relationships of aryl fluorosulfate-based inhibitors as novel antitubercular agents.
Bioorg Med Chem Lett
; 98: 129596, 2024 Jan 15.
Article
in English
| MEDLINE | ID: mdl-38142914
3.
The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis.
Proc Natl Acad Sci U S A
; 115(42): 10750-10755, 2018 10 16.
Article
in English
| MEDLINE | ID: mdl-30282735
4.
Suppressors of superoxide production from mitochondrial complex III.
Nat Chem Biol
; 11(11): 834-6, 2015 Nov.
Article
in English
| MEDLINE | ID: mdl-26368590
5.
Pharmacological stabilization of the native state of full-length immunoglobulin light chains to treat light chain amyloidosis.
Curr Opin Chem Biol
; 75: 102319, 2023 08.
Article
in English
| MEDLINE | ID: mdl-37279624
6.
Cellular Target Deconvolution of Small Molecules Using a Selection-Based Genetic Screening Platform.
ACS Cent Sci
; 8(10): 1424-1434, 2022 Oct 26.
Article
in English
| MEDLINE | ID: mdl-36313155
7.
Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design.
J Med Chem
; 64(9): 6273-6299, 2021 05 13.
Article
in English
| MEDLINE | ID: mdl-33939422
8.
Discovery and SAR of a series of 4,6-diamino-1,3,5-triazin-2-ol as novel non-nucleoside reverse transcriptase inhibitors of HIV-1.
Bioorg Med Chem Lett
; 20(22): 6592-6, 2010 Nov 15.
Article
in English
| MEDLINE | ID: mdl-20888224
9.
Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic.
Science
; 369(6506): 993-999, 2020 Aug 21.
Article
in English
| MEDLINE | ID: mdl-32820126
10.
Short-course quinazoline drug treatments are effective in the Litomosoides sigmodontis and Brugia pahangi jird models.
Int J Parasitol Drugs Drug Resist
; 12: 18-27, 2020 04.
Article
in English
| MEDLINE | ID: mdl-31869759
11.
Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133.
J Med Chem
; 63(6): 2958-2973, 2020 03 26.
Article
in English
| MEDLINE | ID: mdl-32077280
12.
Substrate optimization for monitoring cathepsin C activity in live cells.
Bioorg Med Chem
; 17(3): 1064-70, 2009 Feb 01.
Article
in English
| MEDLINE | ID: mdl-18313933
13.
Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections.
Sci Transl Med
; 11(491)2019 05 08.
Article
in English
| MEDLINE | ID: mdl-31068442
14.
Discovery of inhibitors of the channel-activating protease prostasin (CAP1/PRSS8) utilizing structure-based design.
Bioorg Med Chem Lett
; 18(22): 5895-9, 2008 Nov 15.
Article
in English
| MEDLINE | ID: mdl-18752942
15.
Targeted Disruption of Myc-Max Oncoprotein Complex by a Small Molecule.
ACS Chem Biol
; 12(11): 2715-2719, 2017 11 17.
Article
in English
| MEDLINE | ID: mdl-28976731
16.
Screening transthyretin amyloid fibril inhibitors: characterization of novel multiprotein, multiligand complexes by mass spectrometry.
Structure
; 10(6): 851-63, 2002 Jun.
Article
in English
| MEDLINE | ID: mdl-12057199
17.
Suppressors of Superoxide-H2O2 Production at Site IQ of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury.
Cell Metab
; 24(4): 582-592, 2016 10 11.
Article
in English
| MEDLINE | ID: mdl-27667666
18.
The Tuberculosis Drug Accelerator at year 10: what have we learned?
Nat Med
; 27(8): 1333-1337, 2021 08.
Article
in English
| MEDLINE | ID: mdl-34226736
19.
Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.
J Med Chem
; 48(5): 1576-87, 2005 Mar 10.
Article
in English
| MEDLINE | ID: mdl-15743199
20.
Chemical activation of the mechanotransduction channel Piezo1.
Elife
; 42015 May 22.
Article
in English
| MEDLINE | ID: mdl-26001275