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Results 1 - 20 de 41

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1.

Synergistic effects of ß-amyloid and ceramide-induced insulin resistance on mitochondrial metabolism in neuronal cells.

Kwon, Bumsup; Gamache, Timothy; Lee, Han-Kyu; Querfurth, Henry W.

Biochim Biophys Acta ; 1852(9): 1810-23, 2015 Sep.

Article in English | MEDLINE | ID: mdl-26022371

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2.

Aberrant cell cycle reentry in human and experimental inclusion body myositis and polymyositis.

Kwon, Bumsup; Kumar, Pravir; Lee, Han-Kyu; Zeng, Ling; Walsh, Kenneth; Fu, Qinghao; Barakat, Amey; Querfurth, Henry W.

Hum Mol Genet ; 23(14): 3681-94, 2014 Jul 15.

Article in English | MEDLINE | ID: mdl-24556217

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4065145
https://dx.doi.org/10.1093/hmg/ddu077

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3.

Oleate prevents palmitate-induced mitochondrial dysfunction, insulin resistance and inflammatory signaling in neuronal cells.

Kwon, Bumsup; Lee, Han-Kyu; Querfurth, Henry W.

Biochim Biophys Acta ; 1843(7): 1402-13, 2014 Jul.

Article in English | MEDLINE | ID: mdl-24732014

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4.

Spontaneous Intracranial Hemorrhages in a Community of Asian Americans: Case Series and Literature Review.

Querfurth, Henry; Marczak, Izabella; Rahimian, Nasrin; Jijakli, Amir; Green-LaRoche, Deborah.

Cureus ; 16(1): e52128, 2024 Jan.

Article in English | MEDLINE | ID: mdl-38344578

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10858811
https://dx.doi.org/10.7759/cureus.52128

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5.

Correction: A PDK-1 allosteric agonist neutralizes insulin signaling derangements and beta-amyloid toxicity in neuronal cells and in vitro.

Querfurth, Henry; Marshall, John; Parang, Keykavous; Rioult-Pedotti, Mengia S; Tiwari, Rakesh; Kwon, Bumsup; Reisinger, Steve; Lee, Han-Kyu.

PLoS One ; 19(5): e0304731, 2024.

Article in English | MEDLINE | ID: mdl-38809827

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11135755
https://dx.doi.org/10.1371/journal.pone.0304731

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6.

A PDK-1 allosteric agonist improves spatial learning and memory in a ßAPP/PS-1 transgenic mouse-high fat diet intervention model of Alzheimer's disease.

Querfurth, Henry; Slitt, Angela; DiCamillo, Amy; Surles, Nathan; DeBoef, Brenton; Lee, Han-Kyu.

Behav Brain Res ; 438: 114183, 2023 02 13.

Article in English | MEDLINE | ID: mdl-36404570

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7.

Clinical and Scientific Challenges to Effectiveness Studies Under Coverage with Evidence Development in Alzheimer's Disease.

Morin, Peter J; Zhang, Quanwu; Xia, Weiming; Miller, Donald; Querfurth, Henry; Tahami Monfared, Amir Abbas.

Neurol Ther ; 12(3): 721-726, 2023 Jun.

Article in English | MEDLINE | ID: mdl-36933140

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10195925
https://dx.doi.org/10.1007/s40120-023-00462-z

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8.

Reduction of Phosphorylated Tau in Alzheimer's Disease Induced Pluripotent Stem Cell-Derived Neuro-Spheroids by Rho-Associated Coiled-Coil Kinase Inhibitor Fasudil.

Giunti, Elisa; Collu, Roberto; Daley, Sarah; Querfurth, Henry; Morin, Peter; Killick, Richard; Melamed, Rachel D; Xia, Weiming.

J Alzheimers Dis ; 96(4): 1695-1709, 2023.

Article in English | MEDLINE | ID: mdl-38007655

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9.

Cross-functional E3 ligases Parkin and C-terminus Hsp70-interacting protein in neurodegenerative disorders.

Kumar, Pravir; Pradhan, Kaveri; Karunya, R; Ambasta, Rashmi K; Querfurth, Henry W.

J Neurochem ; 120(3): 350-70, 2012 Feb.

Article in English | MEDLINE | ID: mdl-22098618

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10.

Foxo/atrogin induction in human and experimental myositis.

Lee, Han-Kyu; Rocnik, Edward; Fu, Qinghao; Kwon, Bumsup; Zeng, Ling; Walsh, Kenneth; Querfurth, Henry.

Neurobiol Dis ; 46(2): 463-75, 2012 May.

Article in English | MEDLINE | ID: mdl-22590725

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11.

A PDK-1 allosteric agonist neutralizes insulin signaling derangements and beta-amyloid toxicity in neuronal cells and in vitro.

Querfurth, Henry; Marshall, John; Parang, Keykavous; Rioult-Pedotti, Mengia S; Tiwari, Rakesh; Kwon, Bumsup; Reisinger, Steve; Lee, Han-Kyu.

PLoS One ; 17(1): e0261696, 2022.

Article in English | MEDLINE | ID: mdl-35061720

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8782417
https://dx.doi.org/10.1371/journal.pone.0261696

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12.

Parkin promotes intracellular Abeta1-42 clearance.

Burns, Mark P; Zhang, Lihua; Rebeck, G William; Querfurth, Henry W; Moussa, Charbel E-H.

Hum Mol Genet ; 18(17): 3206-16, 2009 Sep 01.

Article in English | MEDLINE | ID: mdl-19483198

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2733820
https://dx.doi.org/10.1093/hmg/ddp258

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13.

Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration.

Querfurth, Henry; Lee, Han-Kyu.

Mol Neurodegener ; 16(1): 44, 2021 07 02.

Article in English | MEDLINE | ID: mdl-34215308

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8252260
https://dx.doi.org/10.1186/s13024-021-00428-5

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14.

Parkin reverses intracellular beta-amyloid accumulation and its negative effects on proteasome function.

Rosen, Kenneth M; Moussa, Charbel E-H; Lee, Han-Kyu; Kumar, Pravir; Kitada, Tohru; Qin, Gangjian; Fu, Qinghao; Querfurth, Henry W.

J Neurosci Res ; 88(1): 167-78, 2010 Jan.

Article in English | MEDLINE | ID: mdl-19610108

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2844439
https://dx.doi.org/10.1002/jnr.22178

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15.

Ophthalmodynamometry for ICP prediction and pilot test on Mt. Everest.

Querfurth, Henry W; Lieberman, Philip; Arms, Steve; Mundell, Steve; Bennett, Michael; van Horne, Craig.

BMC Neurol ; 10: 106, 2010 Nov 01.

Article in English | MEDLINE | ID: mdl-21040572

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2987855
https://dx.doi.org/10.1186/1471-2377-10-106

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16.

mTOR Mysteries: Nuances and Questions About the Mechanistic Target of Rapamycin in Neurodegeneration.

Norwitz, Nicholas G; Querfurth, Henry.

Front Neurosci ; 14: 775, 2020.

Article in English | MEDLINE | ID: mdl-32903821

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7438931
https://dx.doi.org/10.3389/fnins.2020.00775

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17.

Increased intraneuronal resting [Ca2+] in adult Alzheimer's disease mice.

Lopez, José R; Lyckman, Alvin; Oddo, Salvatore; Laferla, Frank M; Querfurth, Henry W; Shtifman, Alexander.

J Neurochem ; 105(1): 262-71, 2008 Apr.

Article in English | MEDLINE | ID: mdl-18021291

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18.

Alzheimer's disease.

Querfurth, Henry W; LaFerla, Frank M.

N Engl J Med ; 362(4): 329-44, 2010 Jan 28.

Article in English | MEDLINE | ID: mdl-20107219

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19.

New onset seizures in a patient with Long QT Syndrome (LQTS2) and a pathogenic carboxyl-terminus frameshift variant of the KCNH2 gene.

Zarroli, Katherine; Querfurth, Henry.

J Clin Neurosci ; 53: 253-255, 2018 Jul.

Article in English | MEDLINE | ID: mdl-29739726

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20.

Transgenic expression of beta-APP in fast-twitch skeletal muscle leads to calcium dyshomeostasis and IBM-like pathology.

Moussa, Charbel E-H; Fu, Qinghao; Kumar, Pravir; Shtifman, Alexander; Lopez, Jose R; Allen, Paul D; LaFerla, Frank; Weinberg, David; Magrane, Jordi; Aprahamian, Tamar; Walsh, Kenneth; Rosen, Kenneth M; Querfurth, Henry W.

FASEB J ; 20(12): 2165-7, 2006 Oct.

Article in English | MEDLINE | ID: mdl-16940437

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