Search details
1.
Tonic prime-boost of STING signalling mediates Niemann-Pick disease type C.
Nature
; 596(7873): 570-575, 2021 08.
Article
in English
| MEDLINE | ID: mdl-34290407
2.
ACSS2 promotes systemic fat storage and utilization through selective regulation of genes involved in lipid metabolism.
Proc Natl Acad Sci U S A
; 115(40): E9499-E9506, 2018 10 02.
Article
in English
| MEDLINE | ID: mdl-30228117
3.
Ontogenesis and Modulation of Intestinal Unesterified Cholesterol Sequestration in a Mouse Model of Niemann-Pick C1 Disease.
Dig Dis Sci
; 65(1): 158-167, 2020 01.
Article
in English
| MEDLINE | ID: mdl-31312996
4.
Normalization of Hepatic Homeostasis in the Npc1nmf164 Mouse Model of Niemann-Pick Type C Disease Treated with the Histone Deacetylase Inhibitor Vorinostat.
J Biol Chem
; 292(11): 4395-4410, 2017 03 17.
Article
in English
| MEDLINE | ID: mdl-28031458
5.
Niemann-Pick C1-deficient mice lacking sterol O-acyltransferase 2 have less hepatic cholesterol entrapment and improved liver function.
Am J Physiol Gastrointest Liver Physiol
; 315(4): G454-G463, 2018 10 01.
Article
in English
| MEDLINE | ID: mdl-29878847
6.
A functional, genome-wide evaluation of liposensitive yeast identifies the "ARE2 required for viability" (ARV1) gene product as a major component of eukaryotic fatty acid resistance.
J Biol Chem
; 289(7): 4417-31, 2014 Feb 14.
Article
in English
| MEDLINE | ID: mdl-24273168
7.
Histone deacetylase 9 represses cholesterol efflux and alternatively activated macrophages in atherosclerosis development.
Arterioscler Thromb Vasc Biol
; 34(9): 1871-9, 2014 Sep.
Article
in English
| MEDLINE | ID: mdl-25035344
8.
Hepatic entrapment of esterified cholesterol drives continual expansion of whole body sterol pool in lysosomal acid lipase-deficient mice.
Am J Physiol Gastrointest Liver Physiol
; 307(8): G836-47, 2014 Oct 15.
Article
in English
| MEDLINE | ID: mdl-25147230
9.
Carboxylesterases are uniquely expressed among tissues and regulated by nuclear hormone receptors in the mouse.
Drug Metab Dispos
; 41(1): 40-9, 2013 Jan.
Article
in English
| MEDLINE | ID: mdl-23011759
10.
Unesterified cholesterol accumulation in late endosomes/lysosomes causes neurodegeneration and is prevented by driving cholesterol export from this compartment.
J Neurosci
; 31(25): 9404-13, 2011 Jun 22.
Article
in English
| MEDLINE | ID: mdl-21697390
11.
Cyclodextrin mediates rapid changes in lipid balance in Npc1-/- mice without carrying cholesterol through the bloodstream.
J Lipid Res
; 53(11): 2331-42, 2012 Nov.
Article
in English
| MEDLINE | ID: mdl-22892156
12.
Delineation of biochemical, molecular, and physiological changes accompanying bile acid pool size restoration in Cyp7a1(-/-) mice fed low levels of cholic acid.
Am J Physiol Gastrointest Liver Physiol
; 303(2): G263-74, 2012 Jul 15.
Article
in English
| MEDLINE | ID: mdl-22628034
13.
Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouse.
Proc Natl Acad Sci U S A
; 106(7): 2377-82, 2009 Feb 17.
Article
in English
| MEDLINE | ID: mdl-19171898
14.
Molecular markers of brain cholesterol homeostasis are unchanged despite a smaller brain mass in a mouse model of cholesteryl ester storage disease.
Lipids
; 57(1): 3-16, 2022 01.
Article
in English
| MEDLINE | ID: mdl-34618372
15.
Carbohydrate response element binding protein, ChREBP, a transcription factor coupling hepatic glucose utilization and lipid synthesis.
Cell Metab
; 4(2): 107-10, 2006 Aug.
Article
in English
| MEDLINE | ID: mdl-16890538
16.
Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations.
J Lipid Res
; 52(4): 688-98, 2011 Apr.
Article
in English
| MEDLINE | ID: mdl-21289032
17.
Liver X receptor agonists augment human islet function through activation of anaplerotic pathways and glycerolipid/free fatty acid cycling.
J Biol Chem
; 285(8): 5392-404, 2010 Feb 19.
Article
in English
| MEDLINE | ID: mdl-20007976
18.
Impaired insulin secretion and glucose intolerance in synaptotagmin-7 null mutant mice.
Proc Natl Acad Sci U S A
; 105(10): 3992-7, 2008 Mar 11.
Article
in English
| MEDLINE | ID: mdl-18308938
19.
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis.
Cell Metab
; 2(4): 217-25, 2005 Oct.
Article
in English
| MEDLINE | ID: mdl-16213224
20.
Cyclodextrin overcomes the transport defect in nearly every organ of NPC1 mice leading to excretion of sequestered cholesterol as bile acid.
J Lipid Res
; 51(5): 933-44, 2010 May.
Article
in English
| MEDLINE | ID: mdl-19965601