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1.
Phytocannabinoid Pharmacology: Medicinal Properties of Cannabis sativa Constituents Aside from the "Big Two".
J Nat Prod
; 84(1): 142-160, 2021 01 22.
Article
in English
| MEDLINE | ID: mdl-33356248
2.
Safety and tolerability of CFI-400945, a first-in-class, selective PLK4 inhibitor in advanced solid tumours: a phase 1 dose-escalation trial.
Br J Cancer
; 121(4): 318-324, 2019 08.
Article
in English
| MEDLINE | ID: mdl-31303643
3.
Design and optimization of (3-aryl-1H-indazol-6-yl)spiro[cyclopropane-1,3'-indolin]-2'-ones as potent PLK4 inhibitors with oral antitumor efficacy.
Bioorg Med Chem Lett
; 26(19): 4625-4630, 2016 10 01.
Article
in English
| MEDLINE | ID: mdl-27592744
4.
Physical and pharmacokinetic characterization of Soluvec™, a novel, solvent-free aqueous ivermectin formulation.
Ther Deliv
; 14(6): 391-399, 2023 06.
Article
in English
| MEDLINE | ID: mdl-37535333
5.
Spiro-naphthyridinone piperidines as inhibitors of S. aureus and E. coli enoyl-ACP reductase (FabI).
Bioorg Med Chem Lett
; 19(18): 5355-8, 2009 Sep 15.
Article
in English
| MEDLINE | ID: mdl-19682901
6.
2,3,4,5-Tetrahydro-1H-pyrido[2,3-b and e][1,4]diazepines as inhibitors of the bacterial enoyl ACP reductase, FabI.
Bioorg Med Chem Lett
; 19(18): 5359-62, 2009 Sep 15.
Article
in English
| MEDLINE | ID: mdl-19682900
7.
Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent.
ACS Med Chem Lett
; 7(7): 671-5, 2016 Jul 14.
Article
in English
| MEDLINE | ID: mdl-27437075
8.
Use of analogues of methionine and methionyl adenylate to sample conformational changes during catalysis in Escherichia coli methionyl-tRNA synthetase.
J Mol Biol
; 332(1): 59-72, 2003 Sep 05.
Article
in English
| MEDLINE | ID: mdl-12946347
9.
The discovery of Polo-like kinase 4 inhibitors: design and optimization of spiro[cyclopropane-1,3'[3H]indol]-2'(1'H).ones as orally bioavailable antitumor agents.
J Med Chem
; 58(1): 130-46, 2015 Jan 08.
Article
in English
| MEDLINE | ID: mdl-24867403
10.
The discovery of Polo-like kinase 4 inhibitors: identification of (1R,2S).2-(3-((E).4-(((cis).2,6-dimethylmorpholino)methyl)styryl). 1H.indazol-6-yl)-5'-methoxyspiro[cyclopropane-1,3'-indolin]-2'-one (CFI-400945) as a potent, orally active antitumor agent.
J Med Chem
; 58(1): 147-69, 2015 Jan 08.
Article
in English
| MEDLINE | ID: mdl-25723005
11.
The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3-(4-(heterocyclyl)phenyl)-1H-indazole-5-carboxamides as Anticancer Agents.
J Med Chem
; 58(8): 3366-92, 2015 Apr 23.
Article
in English
| MEDLINE | ID: mdl-25763473
12.
Methionine in and out of proteins: targets for drug design.
Curr Med Chem
; 9(3): 385-409, 2002 Feb.
Article
in English
| MEDLINE | ID: mdl-11860363
13.
Synthesis and structure-activity relationships of novel arylpiperazines as potent and selective agonists of the melanocortin subtype-4 receptor.
J Med Chem
; 47(3): 744-55, 2004 Jan 29.
Article
in English
| MEDLINE | ID: mdl-14736255
14.
The discovery of PLK4 inhibitors: (E)-3-((1H-Indazol-6-yl)methylene)indolin-2-ones as novel antiproliferative agents.
J Med Chem
; 56(15): 6069-87, 2013 Aug 08.
Article
in English
| MEDLINE | ID: mdl-23829549
15.
Synthesis of an alpha-aminophosphonate nucleoside as an inhibitor of S-adenosyl-L-homocysteine hydrolase.
Bioorg Med Chem Lett
; 12(3): 457-60, 2002 Feb 11.
Article
in English
| MEDLINE | ID: mdl-11814819
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