Search | VHL CLAP/WR-PAHO/WHO

1.

Getting a Grip on Microtubules.

Schaletzky, Julia; Rape, Michael.

Cell ; 164(5): 836-7, 2016 Feb 25.

Article in English | MEDLINE | ID: mdl-26919420

2.

MyosinA is a druggable target in the widespread protozoan parasite Toxoplasma gondii.

Kelsen, Anne; Kent, Robyn S; Snyder, Anne K; Wehri, Eddie; Bishop, Stephen J; Stadler, Rachel V; Powell, Cameron; Martorelli di Genova, Bruno; Rompikuntal, Pramod K; Boulanger, Martin J; Warshaw, David M; Westwood, Nicholas J; Schaletzky, Julia; Ward, Gary E.

PLoS Biol ; 21(5): e3002110, 2023 05.

Article in English | MEDLINE | ID: mdl-37155705

3.

SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA.

Jack, Amanda; Ferro, Luke S; Trnka, Michael J; Wehri, Eddie; Nadgir, Amrut; Nguyenla, Xammy; Fox, Douglas; Costa, Katelyn; Stanley, Sarah; Schaletzky, Julia; Yildiz, Ahmet.

PLoS Biol ; 19(10): e3001425, 2021 10.

Article in English | MEDLINE | ID: mdl-34634033

4.

A proposed workflow for proactive virus surveillance and prediction of variants for vaccine design.

Baker, Jordan J; Mathy, Christopher J P; Schaletzky, Julia.

PLoS Comput Biol ; 17(12): e1009624, 2021 12.

Article in English | MEDLINE | ID: mdl-34914686

5.

Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design.

Moussaoui, Dihia; Robblee, James P; Robert-Paganin, Julien; Auguin, Daniel; Fisher, Fabio; Fagnant, Patricia M; Macfarlane, Jill E; Schaletzky, Julia; Wehri, Eddie; Mueller-Dieckmann, Christoph; Baum, Jake; Trybus, Kathleen M; Houdusse, Anne.

Nat Commun ; 14(1): 3463, 2023 06 12.

Article in English | MEDLINE | ID: mdl-37308472

6.

Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis.

Hendricks, Joseph M; Doubravsky, Cody E; Wehri, Eddie; Li, Zhipeng; Roberts, Melissa A; Deol, Kirandeep K; Lange, Mike; Lasheras-Otero, Irene; Momper, Jeremiah D; Dixon, Scott J; Bersuker, Kirill; Schaletzky, Julia; Olzmann, James A.

Cell Chem Biol ; 30(9): 1090-1103.e7, 2023 09 21.

Article in English | MEDLINE | ID: mdl-37178691

7.

Mercapto-pyrimidines are reversible covalent inhibitors of the papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replication.

Bajaj, Teena; Wehri, Eddie; Suryawanshi, Rahul K; King, Elizabeth; Pardeshi, Kundan Singh; Behrouzi, Kamyar; Khodabakhshi, Zahra; Schulze-Gahmen, Ursula; Kumar, G Renuka; Mofrad, Mohammad R K; Nomura, Daniel K; Ott, Melanie; Schaletzky, Julia; Murthy, Niren.

RSC Adv ; 13(26): 17667-17677, 2023 Jun 09.

Article in English | MEDLINE | ID: mdl-37312993

8.

An intranasal ASO therapeutic targeting SARS-CoV-2.

Zhu, Chi; Lee, Justin Y; Woo, Jia Z; Xu, Lei; Nguyenla, Xammy; Yamashiro, Livia H; Ji, Fei; Biering, Scott B; Van Dis, Erik; Gonzalez, Federico; Fox, Douglas; Wehri, Eddie; Rustagi, Arjun; Pinsky, Benjamin A; Schaletzky, Julia; Blish, Catherine A; Chiu, Charles; Harris, Eva; Sadreyev, Ruslan I; Stanley, Sarah; Kauppinen, Sakari; Rouskin, Silvi; Näär, Anders M.

Nat Commun ; 13(1): 4503, 2022 08 03.

Article in English | MEDLINE | ID: mdl-35922434

9.

Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells.

Nguyenla, Xammy; Wehri, Eddie; Van Dis, Erik; Biering, Scott B; Yamashiro, Livia H; Zhu, Chi; Stroumza, Julien; Dugast-Darzacq, Claire; Graham, Thomas G W; Wang, Xuanting; Jockusch, Steffen; Tao, Chuanjuan; Chien, Minchen; Xie, Wei; Patel, Dinshaw J; Meyer, Cindy; Garzia, Aitor; Tuschl, Thomas; Russo, James J; Ju, Jingyue; Näär, Anders M; Stanley, Sarah; Schaletzky, Julia.

Sci Rep ; 12(1): 18506, 2022 11 02.

Article in English | MEDLINE | ID: mdl-36323770

10.

Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection.

Biering, Scott B; Sarnik, Sylvia A; Wang, Eleanor; Zengel, James R; Leist, Sarah R; Schäfer, Alexandra; Sathyan, Varun; Hawkins, Padraig; Okuda, Kenichi; Tau, Cyrus; Jangid, Aditya R; Duffy, Connor V; Wei, Jin; Gilmore, Rodney C; Alfajaro, Mia Madel; Strine, Madison S; Nguyenla, Xammy; Van Dis, Erik; Catamura, Carmelle; Yamashiro, Livia H; Belk, Julia A; Begeman, Adam; Stark, Jessica C; Shon, D Judy; Fox, Douglas M; Ezzatpour, Shahrzad; Huang, Emily; Olegario, Nico; Rustagi, Arjun; Volmer, Allison S; Livraghi-Butrico, Alessandra; Wehri, Eddie; Behringer, Richard R; Cheon, Dong-Joo; Schaletzky, Julia; Aguilar, Hector C; Puschnik, Andreas S; Button, Brian; Pinsky, Benjamin A; Blish, Catherine A; Baric, Ralph S; O'Neal, Wanda K; Bertozzi, Carolyn R; Wilen, Craig B; Boucher, Richard C; Carette, Jan E; Stanley, Sarah A; Harris, Eva; Konermann, Silvana; Hsu, Patrick D.

Nat Genet ; 54(8): 1078-1089, 2022 08.

Article in English | MEDLINE | ID: mdl-35879412

11.

SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA.

Jack, Amanda; Ferro, Luke S; Trnka, Michael J; Wehri, Eddie; Nadgir, Amrut; Nguyenla, Xammy; Costa, Katelyn; Stanley, Sarah; Schaletzky, Julia; Yildiz, Ahmet.

bioRxiv ; 2021 Mar 29.

Article in English | MEDLINE | ID: mdl-32995779

12.

Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy.

Chuang, Chihyuan; Collibee, Scott; Ashcraft, Luke; Wang, Wenyue; Vander Wal, Mark; Wang, Xiaolin; Hwee, Darren T; Wu, Yangsong; Wang, Jingying; Chin, Eva R; Cremin, Peadar; Zamora, Jeanelle; Hartman, James; Schaletzky, Julia; Wehri, Eddie; Robertson, Laura A; Malik, Fady I; Morgan, Bradley P.

J Med Chem ; 64(19): 14142-14152, 2021 10 14.

Article in English | MEDLINE | ID: mdl-34606259

13.

Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function.

Collibee, Scott E; Bergnes, Gustave; Chuang, Chihyuan; Ashcraft, Luke; Gardina, Jeffrey; Garard, Marc; Jamison, Chris R; Lu, Kevin; Lu, Pu-Ping; Muci, Alexander; Romero, Antonio; Valkevich, Ellen; Wang, Wenyue; Warrington, Jeffrey; Yao, Bing; Durham, Nickie; Hartman, James; Marquez, Anna; Hinken, Aaron; Schaletzky, Julia; Xu, Donghong; Hwee, Darren T; Morgans, David; Malik, Fady I; Morgan, Bradley P.

J Med Chem ; 64(20): 14930-14941, 2021 10 28.

Article in English | MEDLINE | ID: mdl-34636234

14.

Screening a Library of FDA-Approved and Bioactive Compounds for Antiviral Activity against SARS-CoV-2.

Biering, Scott B; Van Dis, Erik; Wehri, Eddie; Yamashiro, Livia H; Nguyenla, Xammy; Dugast-Darzacq, Claire; Graham, Thomas G W; Stroumza, Julien R; Golovkine, Guillaume R; Roberts, Allison W; Fines, Daniel M; Spradlin, Jessica N; Ward, Carl C; Bajaj, Teena; Dovala, Dustin; Schulze-Gamen, Ursula; Bajaj, Ruchika; Fox, Douglas M; Ott, Melanie; Murthy, Niren; Nomura, Daniel K; Schaletzky, Julia; Stanley, Sarah A.

ACS Infect Dis ; 7(8): 2337-2351, 2021 08 13.

Article in English | MEDLINE | ID: mdl-34129317

15.

Ribosome binding to and dissociation from translocation sites of the endoplasmic reticulum membrane.

Schaletzky, Julia; Rapoport, Tom A.

Mol Biol Cell ; 17(9): 3860-9, 2006 Sep.

Article in English | MEDLINE | ID: mdl-16822833

16.

Discovery of Tirasemtiv, the First Direct Fast Skeletal Muscle Troponin Activator.

Collibee, Scott E; Bergnes, Gustave; Muci, Alexander; Browne, William F; Garard, Marc; Hinken, Aaron C; Russell, Alan J; Suehiro, Ion; Hartman, James; Kawas, Raja; Lu, Pu-Ping; Lee, Kenneth H; Marquez, David; Tomlinson, Matthew; Xu, Donghong; Kennedy, Adam; Hwee, Darren; Schaletzky, Julia; Leung, Kwan; Malik, Fady I; Morgans, David J; Morgan, Bradley P.

ACS Med Chem Lett ; 9(4): 354-358, 2018 Apr 12.

Article in English | MEDLINE | ID: mdl-29670700

17.

The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes.

Short, Benjamin; Preisinger, Christian; Schaletzky, Julia; Kopajtich, Robert; Barr, Francis A.

Curr Biol ; 12(20): 1792-5, 2002 Oct 15.

Article in English | MEDLINE | ID: mdl-12401177

18.

Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases.

Schaletzky, Julia; Dove, Stephen K; Short, Benjamin; Lorenzo, Oscar; Clague, Michael J; Barr, Francis A.

Curr Biol ; 13(6): 504-9, 2003 Mar 18.

Article in English | MEDLINE | ID: mdl-12646134

19.

Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases.

Russell, Alan J; Hartman, James J; Hinken, Aaron C; Muci, Alexander R; Kawas, Raja; Driscoll, Lena; Godinez, Guillermo; Lee, Kenneth H; Marquez, David; Browne, William F; Chen, Michael M; Clarke, David; Collibee, Scott E; Garard, Marc; Hansen, Richard; Jia, Zhiheng; Lu, Pu-Ping; Rodriguez, Hector; Saikali, Khalil G; Schaletzky, Julia; Vijayakumar, Vipin; Albertus, Daniel L; Claflin, Dennis R; Morgans, David J; Morgan, Bradley P; Malik, Fady I.

Nat Med ; 18(3): 452-5, 2012 Feb 19.

Article in English | MEDLINE | ID: mdl-22344294

20.

Determining the conductance of the SecY protein translocation channel for small molecules.

Saparov, Sapar M; Erlandson, Karl; Cannon, Kurt; Schaletzky, Julia; Schulman, Sol; Rapoport, Tom A; Pohl, Peter.

Mol Cell ; 26(4): 501-9, 2007 May 25.

Article in English | MEDLINE | ID: mdl-17531809

VHL CLAP/WR-PAHO/WHO

Latin-American Center for Perinatology, Woman and Reproductive Health

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Getting a Grip on Microtubules.

MyosinA is a druggable target in the widespread protozoan parasite Toxoplasma gondii.

SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA.

A proposed workflow for proactive virus surveillance and prediction of variants for vaccine design.

Mechanism of small molecule inhibition of Plasmodium falciparum myosin A informs antimalarial drug design.

Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis.

Mercapto-pyrimidines are reversible covalent inhibitors of the papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replication.

An intranasal ASO therapeutic targeting SARS-CoV-2.

Discovery of SARS-CoV-2 antiviral synergy between remdesivir and approved drugs in human lung cells.

Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection.

SARS-CoV-2 nucleocapsid protein forms condensates with viral genomic RNA.

Discovery of Aficamten (CK-274), a Next-Generation Cardiac Myosin Inhibitor for the Treatment of Hypertrophic Cardiomyopathy.

Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function.

Screening a Library of FDA-Approved and Bioactive Compounds for Antiviral Activity against SARS-CoV-2.

Ribosome binding to and dissociation from translocation sites of the endoplasmic reticulum membrane.

Discovery of Tirasemtiv, the First Direct Fast Skeletal Muscle Troponin Activator.

The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes.

Phosphatidylinositol-5-phosphate activation and conserved substrate specificity of the myotubularin phosphatidylinositol 3-phosphatases.

Activation of fast skeletal muscle troponin as a potential therapeutic approach for treating neuromuscular diseases.

Determining the conductance of the SecY protein translocation channel for small molecules.