Search details
1.
Type IIA topoisomerase inhibition by a new class of antibacterial agents.
Nature
; 466(7309): 935-40, 2010 Aug 19.
Article
in English
| MEDLINE | ID: mdl-20686482
2.
Mycobacterium tuberculosis DNA gyrase ATPase domain structures suggest a dissociative mechanism that explains how ATP hydrolysis is coupled to domain motion.
Biochem J
; 456(2): 263-73, 2013 Dec 01.
Article
in English
| MEDLINE | ID: mdl-24015710
3.
Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases.
Bioorg Med Chem Lett
; 23(19): 5437-41, 2013 Oct 01.
Article
in English
| MEDLINE | ID: mdl-23968823
4.
Discovery of functionally distinct anti-C7 monoclonal antibodies and stratification of anti-nicotinic AChR positive Myasthenia Gravis patients.
Front Immunol
; 13: 968206, 2022.
Article
in English
| MEDLINE | ID: mdl-36148231
5.
Structurally Diverse Mitochondrial Branched Chain Aminotransferase (BCATm) Leads with Varying Binding Modes Identified by Fragment Screening.
J Med Chem
; 59(6): 2452-67, 2016 Mar 24.
Article
in English
| MEDLINE | ID: mdl-26938474
6.
Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide.
Acta Crystallogr F Struct Biol Commun
; 71(Pt 10): 1242-6, 2015 Oct.
Article
in English
| MEDLINE | ID: mdl-26457513
7.
Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin.
Nat Commun
; 6: 10048, 2015 Dec 07.
Article
in English
| MEDLINE | ID: mdl-26640131
8.
The Discovery of in Vivo Active Mitochondrial Branched-Chain Aminotransferase (BCATm) Inhibitors by Hybridizing Fragment and HTS Hits.
J Med Chem
; 58(18): 7140-63, 2015 Sep 24.
Article
in English
| MEDLINE | ID: mdl-26090771
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