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1.
RASopathy mutations provide functional insight into the BRAF cysteine-rich domain and reveal the importance of autoinhibition in BRAF regulation.
Mol Cell
; 82(22): 4262-4276.e5, 2022 11 17.
Article
in English
| MEDLINE | ID: mdl-36347258
2.
Revealing the mechanism of action of a first-in-class covalent inhibitor of KRASG12C (ON) and other functional properties of oncogenic KRAS by 31P NMR.
J Biol Chem
; 300(2): 105650, 2024 Feb.
Article
in English
| MEDLINE | ID: mdl-38237681
3.
Machine learning-driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins.
Proc Natl Acad Sci U S A
; 119(1)2022 01 04.
Article
in English
| MEDLINE | ID: mdl-34983849
4.
A Top-Down Proteomic Assay to Evaluate KRAS4B-Compound Engagement.
Anal Chem
; 96(13): 5223-5231, 2024 Apr 02.
Article
in English
| MEDLINE | ID: mdl-38498381
5.
Inhibition of Ras/Raf/MEK/ERK Pathway Signaling by a Stress-Induced Phospho-Regulatory Circuit.
Mol Cell
; 64(5): 875-887, 2016 12 01.
Article
in English
| MEDLINE | ID: mdl-27889448
6.
Revealing KRas4b topology on the membrane surface.
Biochem Biophys Res Commun
; 678: 122-127, 2023 10 20.
Article
in English
| MEDLINE | ID: mdl-37633182
7.
Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane.
Proc Natl Acad Sci U S A
; 117(39): 24258-24268, 2020 09 29.
Article
in English
| MEDLINE | ID: mdl-32913056
8.
Exploring CRD mobility during RAS/RAF engagement at the membrane.
Biophys J
; 121(19): 3630-3650, 2022 10 04.
Article
in English
| MEDLINE | ID: mdl-35778842
9.
Tolypocladamides A-G: Cytotoxic Peptaibols from Tolypocladium inflatum.
J Nat Prod
; 85(6): 1603-1616, 2022 06 24.
Article
in English
| MEDLINE | ID: mdl-35696348
10.
Second harmonic generation detection of Ras conformational changes and discovery of a small molecule binder.
Proc Natl Acad Sci U S A
; 116(35): 17290-17297, 2019 08 27.
Article
in English
| MEDLINE | ID: mdl-31399543
11.
Membrane-bound KRAS approximates an entropic ensemble of configurations.
Biophys J
; 120(18): 4055-4066, 2021 09 21.
Article
in English
| MEDLINE | ID: mdl-34384763
12.
Unveiling the Dynamics of KRAS4b on Lipid Model Membranes.
J Membr Biol
; 254(2): 201-216, 2021 04.
Article
in English
| MEDLINE | ID: mdl-33825026
13.
New weapons to penetrate the armor: Novel reagents and assays developed at the NCI RAS Initiative to enable discovery of RAS therapeutics.
Semin Cancer Biol
; 54: 174-182, 2019 02.
Article
in English
| MEDLINE | ID: mdl-29432816
14.
Anionic Lipids Impact RAS-Binding Site Accessibility and Membrane Binding Affinity of CRAF RBD-CRD.
Biophys J
; 119(3): 525-538, 2020 08 04.
Article
in English
| MEDLINE | ID: mdl-32649863
15.
Quantitative biophysical analysis defines key components modulating recruitment of the GTPase KRAS to the plasma membrane.
J Biol Chem
; 294(6): 2193-2207, 2019 02 08.
Article
in English
| MEDLINE | ID: mdl-30559287
16.
KRAS Prenylation Is Required for Bivalent Binding with Calmodulin in a Nucleotide-Independent Manner.
Biophys J
; 116(6): 1049-1063, 2019 03 19.
Article
in English
| MEDLINE | ID: mdl-30846362
17.
PIP2 Influences the Conformational Dynamics of Membrane-Bound KRAS4b.
Biochemistry
; 58(33): 3537-3545, 2019 08 20.
Article
in English
| MEDLINE | ID: mdl-31339036
18.
Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ.
Proc Natl Acad Sci U S A
; 113(44): E6766-E6775, 2016 11 01.
Article
in English
| MEDLINE | ID: mdl-27791178
19.
K-Ras4B Remains Monomeric on Membranes over a Wide Range of Surface Densities and Lipid Compositions.
Biophys J
; 114(1): 137-145, 2018 01 09.
Article
in English
| MEDLINE | ID: mdl-29320680
20.
The small molecule BI-2852 induces a nonfunctional dimer of KRAS.
Proc Natl Acad Sci U S A
; 117(7): 3363-3364, 2020 02 18.
Article
in English
| MEDLINE | ID: mdl-32047043