Search | VHL CLAP/WR-PAHO/WHO

1.

High-Dimensional Mass Cytometry Reveals Emphysema-associated Changes in the Pulmonary Immune System.

Jia, Li; Li, Na; Abdelaal, Tamim R M; Guo, Nannan; IJsselstein, Marieke E; van Unen, Vincent; Lindelauf, Ciska; Jiang, Qinyue; Xiao, Yanling; Pascutti, M Fernanda; Hiemstra, Pieter S; Koning, Frits; Stolk, Jan; Khedoe, P Padmini S J.

Am J Respir Crit Care Med ; 2024 Mar 27.

Article in English | MEDLINE | ID: mdl-38536165

2.

Keratin 8 is a scaffolding and regulatory protein of ERAD complexes.

Pranke, Iwona Maria; Chevalier, Benoit; Premchandar, Aiswarya; Baatallah, Nesrine; Tomaszewski, Kamil F; Bitam, Sara; Tondelier, Danielle; Golec, Anita; Stolk, Jan; Lukacs, Gergely L; Hiemstra, Pieter S; Dadlez, Michal; Lomas, David A; Irving, James A; Delaunay-Moisan, Agnes; van Anken, Eelco; Hinzpeter, Alexandre; Sermet-Gaudelus, Isabelle; Edelman, Aleksander.

Cell Mol Life Sci ; 79(9): 503, 2022 Sep.

Article in English | MEDLINE | ID: mdl-36045259

3.

Governmental Non-Pharmaceutical Interventions during the COVID-19 Pandemic and the COPD Exacerbation and Respiratory Infection Rate in Patients with Alpha-1 Antitrypsin Deficiency.

Kappe, Naomi Nanke; Alagem, Noga; Tov, Naveh; Stolk, Jan.

COPD ; 20(1): 292-297, 2023 12.

Article in English | MEDLINE | ID: mdl-37665565

4.

Fibrosis-Related Gene Profiling in Liver Biopsies of PiZZ α1-Antitrypsin Children with Different Clinical Courses.

Kamp, Jan C; Kappe, Naomi N; Moro, Carlos Fernández; Fuge, Jan; Kuehnel, Mark P; Wrenger, Sabine; Welte, Tobias; Hoek, Bart van; Jonigk, Danny D; Khedoe, Padmini P S J; Strnad, Pavel; Björnstedt, Mikael; Stolk, Jan; Janciauskiene, Sabina; Nemeth, Antal.

Int J Mol Sci ; 24(3)2023 Jan 27.

Article in English | MEDLINE | ID: mdl-36768808

5.

Organoid-based expansion of patient-derived primary alveolar type 2 cells for establishment of alveolus epithelial Lung-Chip cultures.

van Riet, Sander; van Schadewijk, Annemarie; Khedoe, P Padmini S J; Limpens, Ronald W A L; Bárcena, Montserrat; Stolk, Jan; Hiemstra, Pieter S; van der Does, Anne M.

Am J Physiol Lung Cell Mol Physiol ; 322(4): L526-L538, 2022 04 01.

Article in English | MEDLINE | ID: mdl-35137633

6.

Liver Transplantation.

Kappe, Naomi N; Stolk, Jan; van Hoek, Bart.

N Engl J Med ; 390(4): 387, 2024 Jan 25.

Article in English | MEDLINE | ID: mdl-38265663

7.

Clinical and functional characteristics of individuals with alpha-1 antitrypsin deficiency: EARCO international registry.

Miravitlles, Marc; Turner, Alice M; Torres-Duran, María; Tanash, Hanan; Rodríguez-García, Carlota; López-Campos, José Luis; Chlumsky, Jan; Guimaraes, Catarina; Rodríguez-Hermosa, Juan Luis; Corsico, Angelo; Martinez-González, Cristina; Hernández-Pérez, José María; Bustamante, Ana; Parr, David G; Casas-Maldonado, Francisco; Hecimovic, Ana; Janssens, Wim; Lara, Beatriz; Barrecheguren, Miriam; González, Cruz; Stolk, Jan; Esquinas, Cristina; Clarenbach, Christian F.

Respir Res ; 23(1): 352, 2022 Dec 16.

Article in English | MEDLINE | ID: mdl-36527073

8.

Wnt/ß-catenin signaling is critical for regenerative potential of distal lung epithelial progenitor cells in homeostasis and emphysema.

Hu, Yan; Ng-Blichfeldt, John-Poul; Ota, Chiharu; Ciminieri, Chiara; Ren, Wenhua; Hiemstra, Pieter S; Stolk, Jan; Gosens, Reinoud; Königshoff, Melanie.

Stem Cells ; 38(11): 1467-1478, 2020 11.

Article in English | MEDLINE | ID: mdl-32526076

9.

Protease-Specific Biomarkers to Analyse Protease Inhibitors for Emphysema Associated with Alpha 1-Antitrypsin Deficiency. An Overview of Current Approaches.

Viglio, Simona; Bak, Elisabeth G; Schouten, Iris G M; Iadarola, Paolo; Stolk, Jan.

Int J Mol Sci ; 22(3)2021 Jan 21.

Article in English | MEDLINE | ID: mdl-33494436

10.

The Course of AαVal541 as a Proteinase 3 Specific Neo-Epitope after Alpha-1-Antitrypsin Augmentation in Severe Deficient Patients.

Schouten, Iris G M; Mumford, Richard A; Moes, Dirk Jan A R; Hiemstra, Pieter S; Stolk, Jan.

Int J Mol Sci ; 22(15)2021 Jul 27.

Article in English | MEDLINE | ID: mdl-34360796

11.

Liver Fibrosis and Metabolic Alterations in Adults With alpha-1-antitrypsin Deficiency Caused by the Pi*ZZ Mutation.

Hamesch, Karim; Mandorfer, Mattias; Pereira, Vítor M; Moeller, Linda S; Pons, Monica; Dolman, Grace E; Reichert, Matthias C; Schneider, Carolin V; Woditsch, Vivien; Voss, Jessica; Lindhauer, Cecilia; Fromme, Malin; Spivak, Igor; Guldiken, Nurdan; Zhou, Biaohuan; Arslanow, Anita; Schaefer, Benedikt; Zoller, Heinz; Aigner, Elmar; Reiberger, Thomas; Wetzel, Martin; Siegmund, Britta; Simões, Carolina; Gaspar, Rui; Maia, Luís; Costa, Dalila; Bento-Miranda, Mário; van Helden, Josef; Yagmur, Eray; Bzdok, Danilo; Stolk, Jan; Gleiber, Wolfgang; Knipel, Verena; Windisch, Wolfram; Mahadeva, Ravi; Bals, Robert; Koczulla, Rembert; Barrecheguren, Miriam; Miravitlles, Marc; Janciauskiene, Sabina; Stickel, Felix; Lammert, Frank; Liberal, Rodrigo; Genesca, Joan; Griffiths, William J; Trauner, Michael; Krag, Aleksander; Trautwein, Christian; Strnad, Pavel.

Gastroenterology ; 157(3): 705-719.e18, 2019 09.

Article in English | MEDLINE | ID: mdl-31121167

12.

Methods of Purification and Application Procedures of Alpha1 Antitrypsin: A Long-Lasting History.

Viglio, Simona; Iadarola, Paolo; D'Amato, Maura; Stolk, Jan.

Molecules ; 25(17)2020 Sep 02.

Article in English | MEDLINE | ID: mdl-32887469

13.

Loss of Pulmonary Endothelial Cells in Emphysema Impairs Support of Human Alveolar Epithelial Cell Growth.

Ravi, Abilash; Jia, Li; Wu, Xinhui; van der Meer, Andries D; Gosens, Reinoud; Stolk, Jan; van der Does, Anne M; Koning, Frits; Hiemstra, Pieter S; Khedoe, P Padmini J S.

Am J Respir Cell Mol Biol ; 70(2): 149-152, 2024 Feb.

Article in English | MEDLINE | ID: mdl-38299794

14.

TGF-ß activation impairs fibroblast ability to support adult lung epithelial progenitor cell organoid formation.

Ng-Blichfeldt, John-Poul; de Jong, Tristan; Kortekaas, Rosa K; Wu, Xinhui; Lindner, Michael; Guryev, Victor; Hiemstra, Pieter S; Stolk, Jan; Königshoff, Melanie; Gosens, Reinoud.

Am J Physiol Lung Cell Mol Physiol ; 317(1): L14-L28, 2019 07 01.

Article in English | MEDLINE | ID: mdl-30969812

15.

Efficacy and safety of inhaled α1-antitrypsin in patients with severe α1-antitrypsin deficiency and frequent exacerbations of COPD.

Stolk, Jan; Tov, Naveh; Chapman, Kenneth R; Fernandez, Pablo; MacNee, William; Hopkinson, Nicholas S; Piitulainen, Eeva; Seersholm, Niels; Vogelmeier, Claus F; Bals, Robert; McElvaney, Gerry; Stockley, Robert A.

Eur Respir J ; 54(5)2019 11.

Article in English | MEDLINE | ID: mdl-31467115

16.

Regional lung densities in alpha-1 antitrypsin deficiency compared to predicted values.

Stoel, Berend C; Stolk, Jan; Bakker, M Els; Parr, David G.

Respir Res ; 20(1): 45, 2019 Feb 28.

Article in English | MEDLINE | ID: mdl-30819163

17.

Hepatic-targeted RNA interference provides robust and persistent knockdown of alpha-1 antitrypsin levels in ZZ patients.

Turner, Alice M; Stolk, Jan; Bals, Robert; Lickliter, Jason D; Hamilton, James; Christianson, Dawn R; Given, Bruce D; Burdon, Jonathan G; Loomba, Rohit; Stoller, James K; Teckman, Jeffery H.

J Hepatol ; 69(2): 378-384, 2018 08.

Article in English | MEDLINE | ID: mdl-29572094

18.

Mesenchymal stromal cells: a novel therapy for the treatment of chronic obstructive pulmonary disease?

Broekman, Winifred; Khedoe, Padmini P S J; Schepers, Koen; Roelofs, Helene; Stolk, Jan; Hiemstra, Pieter S.

Thorax ; 73(6): 565-574, 2018 06.

Article in English | MEDLINE | ID: mdl-29653970

19.

Characteristics of individuals with alpha-1 antitrypsin deficiency from Northern and Southern European countries: EARCO international registry.

Miravitlles, Marc; Turner, Alice M; Torres-Duran, María; Tanash, Hanan; Rodríguez-García, Carlota; López-Campos, José Luis; Chlumsky, Jan; Guimaraes, Catarina; Rodríguez-Hermosa, Juan Luis; Corsico, Angelo; Martinez-González, Cristina; Hernández-Pérez, José María; Bustamante, Ana; Parr, David G; Casas-Maldonado, Francisco; Hecimovic, Ana; Janssens, Wim; Lara, Beatriz; Barrecheguren, Miriam; González, Cruz; Stolk, Jan; Esquinas, Cristina; Clarenbach, Christian F.

Eur Respir J ; 61(3)2023 03.

Article in English | MEDLINE | ID: mdl-36997232

20.

Correction: Clinical and functional characteristics of individuals with alpha-1 antitrypsin deficiency: EARCO international registry.

Miravitlles, Marc; Turner, Alice M; Torres-Duran, María; Tanash, Hanan; Rodríguez-García, Carlota; López-Campos, José Luis; Chlumsky, Jan; Guimaraes, Catarina; Rodríguez-Hermosa, Juan Luis; Corsico, Angelo; Martinez-González, Cristina; Hernández-Pérez, José María; Bustamante, Ana; Parr, David G; Casas-Maldonado, Francisco; Hecimovic, Ana; Janssens, Wim; Lara, Beatriz; Barrecheguren, Miriam; González, Cruz; Stolk, Jan; Esquinas, Cristina; Clarenbach, Christian F.

Respir Res ; 24(1): 57, 2023 Feb 18.

Article in English | MEDLINE | ID: mdl-36800958

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High-Dimensional Mass Cytometry Reveals Emphysema-associated Changes in the Pulmonary Immune System.

Keratin 8 is a scaffolding and regulatory protein of ERAD complexes.

Governmental Non-Pharmaceutical Interventions during the COVID-19 Pandemic and the COPD Exacerbation and Respiratory Infection Rate in Patients with Alpha-1 Antitrypsin Deficiency.

Fibrosis-Related Gene Profiling in Liver Biopsies of PiZZ α1-Antitrypsin Children with Different Clinical Courses.

Organoid-based expansion of patient-derived primary alveolar type 2 cells for establishment of alveolus epithelial Lung-Chip cultures.

Liver Transplantation.

Clinical and functional characteristics of individuals with alpha-1 antitrypsin deficiency: EARCO international registry.

Wnt/ß-catenin signaling is critical for regenerative potential of distal lung epithelial progenitor cells in homeostasis and emphysema.

Protease-Specific Biomarkers to Analyse Protease Inhibitors for Emphysema Associated with Alpha 1-Antitrypsin Deficiency. An Overview of Current Approaches.

The Course of AαVal541 as a Proteinase 3 Specific Neo-Epitope after Alpha-1-Antitrypsin Augmentation in Severe Deficient Patients.

Liver Fibrosis and Metabolic Alterations in Adults With alpha-1-antitrypsin Deficiency Caused by the Pi*ZZ Mutation.

Methods of Purification and Application Procedures of Alpha1 Antitrypsin: A Long-Lasting History.

Loss of Pulmonary Endothelial Cells in Emphysema Impairs Support of Human Alveolar Epithelial Cell Growth.

TGF-ß activation impairs fibroblast ability to support adult lung epithelial progenitor cell organoid formation.

Efficacy and safety of inhaled α1-antitrypsin in patients with severe α1-antitrypsin deficiency and frequent exacerbations of COPD.

Regional lung densities in alpha-1 antitrypsin deficiency compared to predicted values.

Hepatic-targeted RNA interference provides robust and persistent knockdown of alpha-1 antitrypsin levels in ZZ patients.

Mesenchymal stromal cells: a novel therapy for the treatment of chronic obstructive pulmonary disease?

Characteristics of individuals with alpha-1 antitrypsin deficiency from Northern and Southern European countries: EARCO international registry.

Correction: Clinical and functional characteristics of individuals with alpha-1 antitrypsin deficiency: EARCO international registry.