Search | VHL CLAP/WR-PAHO/WHO

1.

Targeted single-cell RNA sequencing of transcription factors enhances the identification of cell types and trajectories.

Pokhilko, Alexandra; Handel, Adam E; Curion, Fabiola; Volpato, Viola; Whiteley, Emma S; Bøstrand, Sunniva; Newey, Sarah E; Akerman, Colin J; Webber, Caleb; Clark, Michael B; Bowden, Rory; Cader, M Zameel.

Genome Res ; 31(6): 1069-1081, 2021 06.

Article in English | MEDLINE | ID: mdl-34011578

2.

Single-Cell Transcriptomics Reveals Conserved Regulatory Networks in Human and Mouse Interneuron Development.

Keefe, Francesca; Monzón-Sandoval, Jimena; Rosser, Anne E; Webber, Caleb; Li, Meng.

Int J Mol Sci ; 24(9)2023 May 01.

Article in English | MEDLINE | ID: mdl-37175835

3.

Cellular α-synuclein pathology is associated with bioenergetic dysfunction in Parkinson's iPSC-derived dopamine neurons.

Zambon, Federico; Cherubini, Marta; Fernandes, Hugo J R; Lang, Charmaine; Ryan, Brent J; Volpato, Viola; Bengoa-Vergniory, Nora; Vingill, Siv; Attar, Moustafa; Booth, Heather D E; Haenseler, Walther; Vowles, Jane; Bowden, Rory; Webber, Caleb; Cowley, Sally A; Wade-Martins, Richard.

Hum Mol Genet ; 28(12): 2001-2013, 2019 06 15.

Article in English | MEDLINE | ID: mdl-30753527

4.

Human-Specific Transcriptome of Ventral and Dorsal Midbrain Dopamine Neurons.

Monzón-Sandoval, Jimena; Poggiolini, Ilaria; Ilmer, Tobias; Wade-Martins, Richard; Webber, Caleb; Parkkinen, Laura.

Ann Neurol ; 87(6): 853-868, 2020 06.

Article in English | MEDLINE | ID: mdl-32167609

5.

The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function.

Ward, Joey; Tunbridge, Elizabeth M; Sandor, Cynthia; Lyall, Laura M; Ferguson, Amy; Strawbridge, Rona J; Lyall, Donald M; Cullen, Breda; Graham, Nicholas; Johnston, Keira J A; Webber, Caleb; Escott-Price, Valentina; O'Donovan, Michael; Pell, Jill P; Bailey, Mark E S; Harrison, Paul J; Smith, Daniel J.

Mol Psychiatry ; 25(11): 3091-3099, 2020 11.

Article in English | MEDLINE | ID: mdl-31168069

6.

Correction: The genomic basis of mood instability: identification of 46 loci in 363,705 UK Biobank participants, genetic correlation with psychiatric disorders, and association with gene expression and function.

Ward, Joey; Tunbridge, Elizabeth M; Sandor, Cynthia; Lyall, Laura M; Ferguson, Amy; Strawbridge, Rona J; Lyall, Donald M; Cullen, Breda; Graham, Nicholas; Johnston, Keira J A; Webber, Caleb; Escott-Price, Valentina; O'Donovan, Michael; Pell, Jill P; Bailey, Mark E S; Harrison, Paul J; Smith, Daniel J.

Mol Psychiatry ; 25(11): 3107, 2020 Nov.

Article in English | MEDLINE | ID: mdl-31363164

7.

Dystonia genes functionally converge in specific neurons and share neurobiology with psychiatric disorders.

Mencacci, Niccolò E; Reynolds, Regina; Ruiz, Sonia Garcia; Vandrovcova, Jana; Forabosco, Paola; Sánchez-Ferrer, Alvaro; Volpato, Viola; Weale, Michael E; Bhatia, Kailash P; Webber, Caleb; Hardy, John; Botía, Juan A; Ryten, Mina.

Brain ; 143(9): 2771-2787, 2020 09 01.

Article in English | MEDLINE | ID: mdl-32889528

8.

Epistasis in Neuropsychiatric Disorders.

Webber, Caleb.

Trends Genet ; 33(4): 256-265, 2017 04.

Article in English | MEDLINE | ID: mdl-28268034

9.

The Parkinson's Disease Genome-Wide Association Study Locus Browser.

Grenn, Francis P; Kim, Jonggeol J; Makarious, Mary B; Iwaki, Hirotaka; Illarionova, Anastasia; Brolin, Kajsa; Kluss, Jillian H; Schumacher-Schuh, Artur F; Leonard, Hampton; Faghri, Faraz; Billingsley, Kimberley; Krohn, Lynne; Hall, Ashley; Diez-Fairen, Monica; Periñán, Maria Teresa; Foo, Jia Nee; Sandor, Cynthia; Webber, Caleb; Fiske, Brian K; Gibbs, J Raphael; Nalls, Mike A; Singleton, Andrew B; Bandres-Ciga, Sara; Reed, Xylena; Blauwendraat, Cornelis.

Mov Disord ; 35(11): 2056-2067, 2020 11.

Article in English | MEDLINE | ID: mdl-32864809

10.

CSF1R inhibitor JNJ-40346527 attenuates microglial proliferation and neurodegeneration in P301S mice.

Mancuso, Renzo; Fryatt, Gemma; Cleal, Madeleine; Obst, Juliane; Pipi, Elena; Monzón-Sandoval, Jimena; Ribe, Elena; Winchester, Laura; Webber, Caleb; Nevado, Alejo; Jacobs, Tom; Austin, Nigel; Theunis, Clara; Grauwen, Karolien; Daniela Ruiz, Eva; Mudher, Amrit; Vicente-Rodriguez, Marta; Parker, Christine A; Simmons, Camilla; Cash, Diana; Richardson, Jill; Jones, Declan N C; Lovestone, Simon; Gómez-Nicola, Diego; Perry, V Hugh.

Brain ; 142(10): 3243-3264, 2019 10 01.

Article in English | MEDLINE | ID: mdl-31504240

11.

RNA sequencing reveals MMP2 and TGFB1 downregulation in LRRK2 G2019S Parkinson's iPSC-derived astrocytes.

Booth, Heather D E; Wessely, Frank; Connor-Robson, Natalie; Rinaldi, Federica; Vowles, Jane; Browne, Cathy; Evetts, Samuel G; Hu, Michele T; Cowley, Sally A; Webber, Caleb; Wade-Martins, Richard.

Neurobiol Dis ; 129: 56-66, 2019 09.

Article in English | MEDLINE | ID: mdl-31085228

12.

Transcriptomic profiling of purified patient-derived dopamine neurons identifies convergent perturbations and therapeutics for Parkinson's disease.

Sandor, Cynthia; Robertson, Paul; Lang, Charmaine; Heger, Andreas; Booth, Heather; Vowles, Jane; Witty, Lorna; Bowden, Rory; Hu, Michele; Cowley, Sally A; Wade-Martins, Richard; Webber, Caleb.

Hum Mol Genet ; 26(3): 552-566, 2017 02 01.

Article in English | MEDLINE | ID: mdl-28096185

13.

Systematic Phenomics Analysis Deconvolutes Genes Mutated in Intellectual Disability into Biologically Coherent Modules.

Kochinke, Korinna; Zweier, Christiane; Nijhof, Bonnie; Fenckova, Michaela; Cizek, Pavel; Honti, Frank; Keerthikumar, Shivakumar; Oortveld, Merel A W; Kleefstra, Tjitske; Kramer, Jamie M; Webber, Caleb; Huynen, Martijn A; Schenck, Annette.

Am J Hum Genet ; 98(1): 149-64, 2016 Jan 07.

Article in English | MEDLINE | ID: mdl-26748517

14.

The clustering of functionally related genes contributes to CNV-mediated disease.

Andrews, Tallulah; Honti, Frantisek; Pfundt, Rolph; de Leeuw, Nicole; Hehir-Kwa, Jayne; Vulto-van Silfhout, Anneke; de Vries, Bert; Webber, Caleb.

Genome Res ; 25(6): 802-13, 2015 Jun.

Article in English | MEDLINE | ID: mdl-25887030

15.

Extensive microRNA-mediated crosstalk between lncRNAs and mRNAs in mouse embryonic stem cells.

Tan, Jennifer Y; Sirey, Tamara; Honti, Frantisek; Graham, Bryony; Piovesan, Allison; Merkenschlager, Matthias; Webber, Caleb; Ponting, Chris P; Marques, Ana C.

Genome Res ; 25(5): 655-66, 2015 May.

Article in English | MEDLINE | ID: mdl-25792609

16.

Diverse type 2 diabetes genetic risk factors functionally converge in a phenotype-focused gene network.

Sandor, Cynthia; Beer, Nicola L; Webber, Caleb.

PLoS Comput Biol ; 13(10): e1005816, 2017 Oct.

Article in English | MEDLINE | ID: mdl-29059180

17.

Synergistic interactions between Drosophila orthologues of genes spanned by de novo human CNVs support multiple-hit models of autism.

Grice, Stuart J; Liu, Ji-Long; Webber, Caleb.

PLoS Genet ; 11(3): e1004998, 2015 Mar.

Article in English | MEDLINE | ID: mdl-25816101

18.

Gene networks underlying convergent and pleiotropic phenotypes in a large and systematically-phenotyped cohort with heterogeneous developmental disorders.

Andrews, Tallulah; Meader, Stephen; Vulto-van Silfhout, Anneke; Taylor, Avigail; Steinberg, Julia; Hehir-Kwa, Jayne; Pfundt, Rolph; de Leeuw, Nicole; de Vries, Bert B A; Webber, Caleb.

PLoS Genet ; 11(3): e1005012, 2015 Mar.

Article in English | MEDLINE | ID: mdl-25781962

19.

Multiplex High-Throughput Targeted Proteomic Assay To Identify Induced Pluripotent Stem Cells.

Baud, Anna; Wessely, Frank; Mazzacuva, Francesca; McCormick, James; Camuzeaux, Stephane; Heywood, Wendy E; Little, Daniel; Vowles, Jane; Tuefferd, Marianne; Mosaku, Olukunbi; Lako, Majlinda; Armstrong, Lyle; Webber, Caleb; Cader, M Zameel; Peeters, Pieter; Gissen, Paul; Cowley, Sally A; Mills, Kevin.

Anal Chem ; 89(4): 2440-2448, 2017 02 21.

Article in English | MEDLINE | ID: mdl-28192931

20.

Haploinsufficiency predictions without study bias.

Steinberg, Julia; Honti, Frantisek; Meader, Stephen; Webber, Caleb.

Nucleic Acids Res ; 43(15): e101, 2015 Sep 03.

Article in English | MEDLINE | ID: mdl-26001969

VHL CLAP/WR-PAHO/WHO

Latin-American Center for Perinatology, Woman and Reproductive Health

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