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1.
Orally Bioavailable Macrocyclic Peptide That Inhibits Binding of PCSK9 to the Low Density Lipoprotein Receptor.
Circulation
; 148(2): 144-158, 2023 07 11.
Article
in English
| MEDLINE | ID: mdl-37125593
2.
Design and synthesis of novel proline based factor XIa selective inhibitors as leads for potential new anticoagulants.
Bioorg Med Chem Lett
; 30(16): 127072, 2020 08 15.
Article
in English
| MEDLINE | ID: mdl-32340773
3.
Augmenting Hit Identification by Virtual Screening Techniques in Small Molecule Drug Discovery.
J Chem Inf Model
; 60(9): 4144-4152, 2020 09 28.
Article
in English
| MEDLINE | ID: mdl-32309939
4.
Discovery of novel aminobenzisoxazole derivatives as orally available factor IXa inhibitors.
Bioorg Med Chem Lett
; 27(11): 2622-2628, 2017 06 01.
Article
in English
| MEDLINE | ID: mdl-28408226
5.
Discovery of phenyl acetamides as potent and selective GPR119 agonists.
Bioorg Med Chem Lett
; 27(5): 1124-1128, 2017 03 01.
Article
in English
| MEDLINE | ID: mdl-28185720
6.
Rapid development of two factor IXa inhibitors from hit to lead.
Bioorg Med Chem Lett
; 25(11): 2321-5, 2015 Jun 01.
Article
in English
| MEDLINE | ID: mdl-25937013
7.
Development of a novel class of potent and selective FIXa inhibitors.
Bioorg Med Chem Lett
; 25(21): 4945-4949, 2015 Nov 01.
Article
in English
| MEDLINE | ID: mdl-25978966
8.
Development of a novel tricyclic class of potent and selective FIXa inhibitors.
Bioorg Med Chem Lett
; 25(22): 5437-43, 2015 Nov 15.
Article
in English
| MEDLINE | ID: mdl-26318999
9.
Novel transcriptome profiling analyses demonstrate that selective peroxisome proliferator-activated receptor γ (PPARγ) modulators display attenuated and selective gene regulatory activity in comparison with PPARγ full agonists.
Mol Pharmacol
; 82(1): 68-79, 2012 Jul.
Article
in English
| MEDLINE | ID: mdl-22496518
10.
Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors.
J Med Chem
; 65(1): 838-856, 2022 01 13.
Article
in English
| MEDLINE | ID: mdl-34967623
11.
Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson's Disease.
J Med Chem
; 65(24): 16801-16817, 2022 12 22.
Article
in English
| MEDLINE | ID: mdl-36475697
12.
Design of potent and selective GPR119 agonists for type II diabetes.
Bioorg Med Chem Lett
; 21(9): 2665-9, 2011 May 01.
Article
in English
| MEDLINE | ID: mdl-21273063
13.
A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors.
J Med Chem
; 64(22): 16770-16800, 2021 11 25.
Article
in English
| MEDLINE | ID: mdl-34704436
14.
Optimization of brain-penetrant picolinamide derived leucine-rich repeat kinase 2 (LRRK2) inhibitors.
RSC Med Chem
; 12(7): 1164-1173, 2021 Jul 21.
Article
in English
| MEDLINE | ID: mdl-34355182
15.
Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug Optimization.
J Med Chem
; 63(21): 12156-12170, 2020 11 12.
Article
in English
| MEDLINE | ID: mdl-32633947
16.
Differential potencies of naturally occurring regioisomers of nitrolinoleic acid in PPARgamma activation.
Biochemistry
; 48(2): 492-8, 2009 Jan 20.
Article
in English
| MEDLINE | ID: mdl-19105608
17.
The differential interactions of peroxisome proliferator-activated receptor gamma ligands with Tyr473 is a physical basis for their unique biological activities.
Mol Pharmacol
; 73(1): 62-74, 2008 Jan.
Article
in English
| MEDLINE | ID: mdl-17940191
18.
A novel selective peroxisome proliferator-activator receptor-gamma modulator-SPPARgammaM5 improves insulin sensitivity with diminished adverse cardiovascular effects.
Eur J Pharmacol
; 584(1): 192-201, 2008 Apr 14.
Article
in English
| MEDLINE | ID: mdl-18346728
19.
Highly functionalized 7-azaindoles as selective PPAR gamma modulators.
Bioorg Med Chem Lett
; 18(17): 4798-801, 2008 Sep 01.
Article
in English
| MEDLINE | ID: mdl-18701276
20.
GPR119 Agonism Increases Glucagon Secretion During Insulin-Induced Hypoglycemia.
Diabetes
; 67(7): 1401-1413, 2018 07.
Article
in English
| MEDLINE | ID: mdl-29669745