RESUMEN
BACKGROUND: Currently, there is a lack of data relating to glycemic parameters and their relationship with C-peptide (CP) and proinsulin (PI) during the partial remission period (PRP) in type 1 diabetes mellitus (T1D). The aim of this study was to evaluate glycemic parameters in children with T1D who are in the PRP using intermittently scanned continuous glucose monitoring systems (isCGMS) and to investigate any relationships between CP and PI levels. METHODS: The study included 21 children who were in the PRP and 31 children who were not. A cross-sectional, non-randomized study was performed. Demographic, clinical data were collected and 2 week- isCGMS data were retrieved. RESULTS: The Serum CP showed a positive correlation with time-in-range in the PRP (p:0.03), however PI showed no correlations with glycemic parameters in both periods. The Serum CP and PI levels and the PI:CP ratio were significantly higher in the PRP group than in the non-PRP group. In the non-PRP group, the PI level was below 0.1 pmol/L (which is the detectable limit) in only 2 of the 17 cases as compared with none in the PRP group. Similarly, only 2 of the 17 children in the non-PRP group had CP levels of less than 0.2 nmol / L, although both had detectable PI levels. Overall time-in-range (3. 9-1.0 mmol/L) was significantly high in the PRP group. In contrast, the mean sensor glucose levels, time spent in hyperglycemia, and coefficient of variation levels (32.2vs 40.5%) were significantly lower in the PRP group. CONCLUSIONS: Although the mean glucose and time in range during the PRP was better than that in the non-PRP group, the glycemic variability during this period was not as low as expected. While the CP levels showed an association with TIR during the PRP, there was no correlation between PI levels and glycemic parameters. Further studies are needed to determine if PI might prove to be a useful parameter in clinical follow-up.
Asunto(s)
Péptido C/sangre , Diabetes Mellitus Tipo 1/sangre , Proinsulina/sangre , Adolescente , Glucemia , Automonitorización de la Glucosa Sanguínea , Niño , Preescolar , Estudios Transversales , Femenino , Humanos , Hiperglucemia/sangre , Hipoglucemiantes/uso terapéutico , Insulina/uso terapéutico , Masculino , Remisión EspontáneaRESUMEN
Understanding the presence, transfer dynamics and depletion of gunshot residues (GSR) on various surfaces is crucial for preserving evidence, reconstructing shooting incidents, and linking suspects to crime scenes. This study aims to explore the transfer and loss of GSR on commonly encountered surfaces such as ceramic, glass, metal, paper, and plastic, as well as the influence of different common hand cleaning methods on secondary transfer. Using scanning electron microscopy (SEM) combined with energy dispersive X-ray analysis (EDX) and automated detection software, we quantified highly indicative three-component characteristic particles (lead, barium, and antimony) on cups made from ceramic, glass, metal, paper, and plastic. Furthermore, we evaluated the amount of secondary transferred particles on these surfaces following various post-discharge hand cleaning methods: washing with water and soap, washing with only water, wiping with wet wipes, or using paper towels. The results demonstrate that counts of secondarily transferred GSR particles vary significantly among surfaces. Specifically, the transferred GSR count was highest on paper, followed by plastic, ceramic, metal, and glass respectively. Post-discharge hand cleaning methods, including washing with water and soap, washing with only water, cleaning with wet wipes, or with paper towel, resulted in substantial loss of GSR count on transferred surfaces. Among these methods, washing with water and soap showed the highest depletion. The empirical evidence provided by our results underscores the importance of considering surface properties, post-shooting activities, and the methods of sample collection and analysis when interpreting transferred GSR analysis. Despite challenges, these insights enhance our ability to link suspects to shooting crimes through careful consideration of the entire context.
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A subset of boarding schools for adolescents was established in 1993 in the rural sections of Eastern Turkey to provide equity in terms of availability of education. Even though these schools were beneficial in many respects, implementation of this institutional model gave rise to many challenges such as weaker relationships with parents and defiance of authority figures. Failure to develop a mature response to these challenges could lead to the development of psychopathologies such as depression, psychosis, and dissociation. The main objective of this study is to assess the incidence of psychopathology and dissociative experiences of the residential female students in the regional boarding schools compared to a control group. 187 female participants, 128 attending boarding school, and 59 attending day school, as the control group, were included in the study. Brief Symptom Inventory (BSI) and Adolescent Dissociative Experiences Scale (ADES) were used as measurement scales. T-test, Mann Whitney-U, Spearman correlation chi-square tests were used to evaluate the association between the variables. There was a significant difference in Interpersonal sensitivity and Psychoticism subscales of BSI. ADES score was found to be significantly higher in the Boarding school group. Boarding school students are at a higher risk of developing psychopathology as a common trauma on a group of people can result in shared dissociation, a collective defense mechanism to cope with the injury, which resembles shared delusional disorder within DSM-V (The Diagnostic and Statistical Manual of Mental Disorders). Screening measures should be implemented in boarding schools to evaluate adolescents for psychopathology and preventive measures should be taken to intervene in the early stages.
RESUMEN
Tourette Syndrome is a neurodevelopmental disorder that is associated with the presence of multiple motor and one or more verbal tics. In this case report, we present a 16 years old Tourette syndrome patient who was diagnosed with comorbid Attention Deficit Hyperactivity Disorder. The patient was evaluated for legal responsibility after she made untrue allegations saying that a bus driver had sexually harassed her. We summarize the case and review the current literature to assess the socio-legal aspects of Tourette syndrome.