RESUMEN
The main objective of technical protective clothing is to enhance people safety at work, which may save their life or keep them healthy away against some hazards. We developed a warning cotton fabric with a traffic safety warning photoluminescence character that continues emitting light for a long period of time after the removal of the illuminant source. Rare earth-doped strontium aluminate was dispersed in an aqueous medium of a polyacrylic-based binder to give a cross-linkable photoluminescent formula to be applied onto cotton substrate employing spray-coat approach. To introduce a transparent photoluminescent film, the Rare earth pigment must be fully dispersed to prevent aggregation. The long-persistent photoluminescent layer was deposited on cotton surface employing different concentrations of the rare earth pigment phosphor. The excitation wavelength maximum band of the spray-coated film on cotton fabric was found to occur at 365 nm, while the emission was recorded at 515 nm. Yellowish-green emissive color was monitored by CIE color data under the ultraviolet excitation source. The spray-coated fabric was characterized by wavelength dispersive X-ray fluorescence (WD-XRF), phosphorescence and excitation spectra, elements mapping, scanning electron microscopy (SEM) and energy-dispersive X-ray (EDX). The comfort measurements were studied by exploring both of fabric stiffness and air-permeability. Furthermore, the spray-coated textile substrates displayed good fastness properties and a reversible luminescent glow in the dark.
RESUMEN
The demand for L-asparaginase is predicted to increase several fold in the future due to its potential clinical applications in the treatment of lymphoid system malignancies and leukemia. Thus identifying suitable sources of production should be considered high priority. Fungi are valuable organisms as they are able to convert what would be considered 'useless' materials into materials that have potential value. The present study provides a proof of concept of production of a new hyperactive L-asparaginase producer (Rhizopus oryzae AM16), which was successfully isolated and sequentially optimized using a semi solid-state fermentation method with a simple and cheap medium produced from wheat bran (WB). The fungus was able to produce an appreciable amount of the enzyme (2,875.9 U) after 8 days of incubation under 85.7% moisture, in the presence of magnesium nitrate (5.0 mg N/mg nitrogen per gram of dry WB) at pH 5.8. Testing the anticancer activity confirmed the ability of the resultant enzyme to inhibit the growth of various types of cancer cells (HepG2, MCF-7, HCT and A549). The IC50 values of the dialyzed enzyme were lower than that of the crude product. Thus, this newly identified and purified L-asparaginase may be a promising anticancer drug.
RESUMEN
The Severe Acute Respiratory Syndrome-related Coronavirus 2 (COVID-19 or SARS-CoV-2) epidemic is professed as world disaster producing a worrying increasing mortality, particularly amongst vulnerable humans worldwide. Whether COVID-19 has a strong ability for acceptable genetic flexibility that amended for breaking immune responses quickly, it is critical to understand the adaptation mechanism between viruses and hosts that allows individuals to follow viral development. This can contribute to finding the appropriate treatment to combat the epidemic. However, the present information about viral adaptation mechanisms in hosts is still insufficient, and future investigations may reveal the unknown. Mutations and genetic variations are naturally occurring; however, the current knowledge about their mechanism and pathways still has many secrets. The present review also provides insights into the immune system, immunological memory, and the development of the COVID-19 vaccine. Other fighting methods against COVID-19 are also highlighted. The potential of antibodies, natural metabolites, and current suggest vaccines were applied to the face of this new threat.