Asunto(s)
Adenocarcinoma/diagnóstico , Liposarcoma/patología , Neoplasias Gástricas/diagnóstico , Adenocarcinoma/patología , Cardias/diagnóstico por imagen , Cardias/patología , Diagnóstico Diferencial , Biopsia por Aspiración con Aguja Fina Guiada por Ultrasonido Endoscópico , Endosonografía , Fundus Gástrico/diagnóstico por imagen , Fundus Gástrico/patología , Mucosa Gástrica/diagnóstico por imagen , Mucosa Gástrica/patología , Tumores del Estroma Gastrointestinal/diagnóstico , Gastroscopía , Humanos , Leiomioma/diagnóstico , Persona de Mediana Edad , Neoplasias Gástricas/patología , Tomografía Computarizada por Rayos XAsunto(s)
Carcinoma Verrugoso/diagnóstico , Neoplasias Esofágicas/diagnóstico , Anciano , Carcinoma Verrugoso/patología , Carcinoma Verrugoso/cirugía , Endosonografía , Neoplasias Esofágicas/patología , Neoplasias Esofágicas/cirugía , Esofagostomía , Esófago/diagnóstico por imagen , Esófago/patología , Esófago/cirugía , Humanos , Masculino , Tomografía Computarizada por Rayos XAsunto(s)
Carcinoma Hepatocelular/diagnóstico por imagen , Carcinoma Hepatocelular/cirugía , Quiste del Colédoco/diagnóstico por imagen , Quiste del Colédoco/patología , Neoplasias Hepáticas/diagnóstico por imagen , Neoplasias Hepáticas/cirugía , Anciano , Biopsia , Carcinoma Hepatocelular/patología , Colangiopancreatografia Retrógrada Endoscópica , Quiste del Colédoco/cirugía , Diagnóstico Diferencial , Endosonografía , Humanos , Pruebas de Función Hepática , Neoplasias Hepáticas/patología , Masculino , Stents , Tomografía Computarizada por Rayos XRESUMEN
Background: End-stage liver disease (ESLD) is not considered a risk factor for atherosclerotic cardiovascular disease (ASCVD). However, lifestyle characteristics commonly associated with increased ASCVD risk are highly prevalent in ESLD. Emerging literature shows a high burden of asymptomatic coronary artery disease (CAD) in patients with ESLD and a high ASCVD risk in liver transplantation (LT) recipients. Coronary artery calcium score (CAC) is a noninvasive test providing reliable CAD risk stratification. We implemented an LT evaluation protocol with CAC playing a central role in triaging and determining the need for further CAD assessment. Here, we inform our results from this early experience. Methods: Patients with ESLD referred for LT evaluation were prospectively studied. We compared accuracy of CAC against that of CAD risk factors/scores, troponin I, dobutamine stress echocardiogram (DSE), and single-photon emission computed tomography (SPECT) to detect coronary stenosis ≥70 (CAD ≥ 70) per left heart catheterization (LHC). Thirty-day post-LT cardiac outcomes were also analyzed. Results: One hundred twenty-four of 148 (84%) patients underwent CAC, 106 (72%) DSE/SPECT, and 50 (34%) LHC. CAC ≥ 400 was found in 35 (28%), 100 to 399 in 17 (14%), and <100 in 72 (58%). LHC identified CAD ≥ 70% in 8 of 29 (28%), 2 of 9 (22%), and 0 of 4, respectively. Two acute coronary syndromes occurred after LT in a patient with CAC 811 (CAD < 70%), and one with CAC 347 (CAD ≥ 70%). No patients with CAC < 100 presented with acute coronary syndrome after LT. When using CAD ≥ 70% as primary endpoint of LT evaluation, CAC ≥ 346 was the only test showing predictive usefulness (negative predictive value 100%). Conclusions: CAC is a promising tool to guide CAD risk stratification and need for LHC during LT evaluation. Patients with a CAC < 100 can safely undergo LT without the need for LHC or cardiac stress testing, whereas a CAC < 346 accurately rules out significant CAD stenosis (≥70%) on LHC, outperforming other CAD risk-stratification strategies.
RESUMEN
Hypermagnesemia is a rare and under-recognized cause of paralytic ileus. We report a case of a 21-year-old primigravida who was managed aggressively for preeclampsia and presented with postpartum paralytic ileus. Detailed history was employed to consider hypermagnesemia-induced ileus as the working diagnosis, and the patient improved with correction of the electrolyte imbalance. Hypermagnesemia-induced lethargy, decreased reflexes, muscle weakness, flaccid paralysis, respiratory muscle paralysis, and cardiac arrest are well-described; however, intestinal smooth muscle dysfunction leading to paralytic ileus has never been reported in the setting of magnesium use for peripartum preeclampsia management.