"Familial Multiple Coagulation Factor Deficiencies of FXI and FXII in an Asymptomatic Saudi Woman".

Factor XI deficiency (FXI) is the third most common coagulation factor deficiency after hemophilia A and B, ie, in the hierarchy after factors VIII and IX, taking into account von Willebrand's factor deficiency, as bleeding disorders are higher than in hemophilia C. Factor XII deficiency (FXII) is a congenital condition, inherited in the vast majority of cases in an autosomal recessive manner, more often associated with thromboembolic complications. A combination of both factor deficiencies has been found very rarely, and it can be familial multiple coagulation factor deficiency (FMCFD). This study reports the case of a 39-year-old woman from Saudi Arabia who had the combination of FXI and FXII deficiencies, known to be on treatment for hypothyroidism and was referred to a hematology clinic with an incidental finding of prolonged activated partial thromboplastin time (aPTT). Although there was no history of bleeding tendency, her siblings had a family history of an unknown type of bleeding disorder. On physical examination, the patient did not show any bruising, petechiae, or ecchymosis. The aPTT was 69 seconds (27-38) with normal use of other hemostatic agents and was corrected after a 50:50 mixing study. Intrinsic coagulation factors were evaluated, and they revealed severe FXI and moderate FXII deficiencies. Due to a strong family history, the patient was diagnosed with FMCFD. In conclusion, familial combined multiple clotting factor deficiency (FCMFD) is a rare condition that requires attention and reporting. The management strategy in such cases has not been well studied, especially in the long-term symptomatic patient with severe but asymptomatic combined FXI and FXII deficiencies, which is an area for review and further study.

Assessment of the Relationship between Dental Anxiety and Oral Health-Related Quality of Life.

BACKGROUND: Dental anxiety and fear are the frequently encountered entities among most of the patients. The present study was conducted to assess the relationship between dental anxiety and quality of life (QoL). MATERIALS AND METHODS: This study comprised of 118 patients. Dental trait anxiety (dental anxiety scale [DAS] and short version of the dental anxiety inventory [S-DAI]), Oral Health Impact Profile (OHIP-14), Decayed, Missing, and Filled Teeth (DMFT) score, and global assessment of functioning were recorded before and after treatment. RESULTS: Out of 118 patients, males were 52 and females were 56. There was a correlation between both oral health ratings and DMFT (P < 0.001). OHIP-14 total score was significantly associated with both dental anxiety measures. DMFT shows significant association with dental anxiety and oral health-related QoL (OH-QoL) (P < 0.05). The mean DAS score before treatment was 17.3 and after treatment was 12.60, S-DAI score was 40.1 and 31.5 before and after treatment respectively, oral health status (patient rating) was 38.4 and 74.20 before and after treatment respectively, oral health status (dentist rating) was 38.7 and 73.1 before and after treatment respectively and aesthetics (dentist rating) was 35.6 and 72.4 before and after treatment respectively. There was improvement of OH-QoL with dental anxiety reduction which was significantly significant (P < 0.05). CONCLUSION: Authors found that there is correlation between dental anxiety and fear with the poor oral health-related oral hygiene.

Effect of Decontamination Treatments on Micro-Shear Bond Strength between Blood-Saliva-Contaminated Post-Etched Dentin Substrate and Composite Resin.

Blood-saliva contamination negatively affects the bonding potential of adhesive agents. The study aimed to assess the effect of various cleaning protocols on micro-shear bond strength (µSBS) between blood-saliva-contaminated post-etched dentin and composite resin in total-etch and self-etch adhesives. The cleaning methods tested were water rinsing, 37.5% phosphoric acid (H3PO4) re-etching, 6% sodium hypochlorite (NaoCl), 2% chlorhexidine gluconate (CXG), isopropyl alcohol (IPA), and pumice. Nono-hybrid composite cylinders with a 3-mm diameter and 2-mm height were directly cured over the dentin substrate, stored for 24 h, and subjected to 12,000 thermocycles. The shear force was exerted with a 200-µm knife-edged chisel-shaped head from a universal testing machine. The type of failure was assessed with stereomicroscope magnified images. The obtained data were evaluated by Kruskal-Wallis and Mann-Whitney U post-hoc tests. Water-rinsed contaminated dentin surfaces showed substantially reduced µSBS in the total etch from 25.93 to 20.29 Mpa and the corresponding values for the one-step self-etch adhesive were 10.10 to 8.8. Re-etching with 37.5% H3Po4 resulted in a recovery of bonding potential in both total-etch (24.58 Mpa) and self-etch adhesive (9.23 Mpa). Alternately, NaoCl and pumice cleaning showed promising results for the total-etch (23.51 Mpa) and self-etch (7.79 Mpa).