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1.

The Chemical Chaperone 4-Phenylbutyric Acid Prevents Alcohol-Induced Liver Injury in Obese KK-A^y Mice.

Suzuki, Maiko; Kon, Kazuyoshi; Ikejima, Kenichi; Arai, Kumiko; Uchiyama, Akira; Aoyama, Tomonori; Yamashina, Shunhei; Ueno, Takashi; Watanabe, Sumio.

Alcohol Clin Exp Res ; 43(4): 617-627, 2019 04.

Artículo en Inglés | MEDLINE | ID: mdl-30748014

2.

Formation of p62-positive inclusion body is associated with macrophage polarization in non-alcoholic fatty liver disease.

Fukushima, Hirofumi; Yamashina, Shunhei; Arakawa, Atsushi; Taniguchi, Gentaro; Aoyama, Tomonori; Uchiyama, Akira; Kon, Kazuyoshi; Ikejima, Kenichi; Watanabe, Sumio.

Hepatol Res ; 48(9): 757-767, 2018 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-29473277

3.

Spleen-derived lipocalin-2 in the portal vein regulates Kupffer cells activation and attenuates the development of liver fibrosis in mice.

Aoyama, Tomonori; Kuwahara-Arai, Kyoko; Uchiyama, Akira; Kon, Kazuyoshi; Okubo, Hironao; Yamashina, Shunhei; Ikejima, Kenichi; Kokubu, Shigehiro; Miyazaki, Akihisa; Watanabe, Sumio.

Lab Invest ; 97(8): 890-902, 2017 08.

Artículo en Inglés | MEDLINE | ID: mdl-28504685

4.

L-carnitine prevents metabolic steatohepatitis in obese diabetic KK-A^y mice.

Kon, Kazuyoshi; Ikejima, Kenichi; Morinaga, Maki; Kusama, Hiromi; Arai, Kumiko; Aoyama, Tomonori; Uchiyama, Akira; Yamashina, Shunhei; Watanabe, Sumio.

Hepatol Res ; 47(3): E44-E54, 2017 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-27062266

5.

Abnormality of autophagic function and cathepsin expression in the liver from patients with non-alcoholic fatty liver disease.

Fukuo, Yuka; Yamashina, Shunhei; Sonoue, Hiroshi; Arakawa, Atsushi; Nakadera, Eisuke; Aoyama, Tomonori; Uchiyama, Akira; Kon, Kazuyoshi; Ikejima, Kenichi; Watanabe, Sumio.

Hepatol Res ; 44(9): 1026-36, 2014 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-24299564

6.

Innate immune responses involving natural killer and natural killer T cells promote liver regeneration after partial hepatectomy in mice.

Hosoya, Satoko; Ikejima, Kenichi; Takeda, Kazuyoshi; Arai, Kumiko; Ishikawa, Sachiko; Yamagata, Hisafumi; Aoyama, Tomonori; Kon, Kazuyoshi; Yamashina, Shunhei; Watanabe, Sumio.

Am J Physiol Gastrointest Liver Physiol ; 304(3): G293-9, 2013 Feb 01.

Artículo en Inglés | MEDLINE | ID: mdl-23086918

7.

Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice.

Meng, Fanli; Wang, Kai; Aoyama, Tomonori; Grivennikov, Sergei I; Paik, YongHan; Scholten, David; Cong, Min; Iwaisako, Keiko; Liu, Xiao; Zhang, Mingjun; Österreicher, Christoph H; Stickel, Felix; Ley, Klaus; Brenner, David A; Kisseleva, Tatiana.

Gastroenterology ; 143(3): 765-776.e3, 2012 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-22687286

8.

Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent.

Aoyama, Tomonori; Paik, Yong-Han; Watanabe, Sumio; Laleu, Benoît; Gaggini, Francesca; Fioraso-Cartier, Laetitia; Molango, Sophie; Heitz, Freddy; Merlot, Cédric; Szyndralewiez, Cédric; Page, Patrick; Brenner, David A.

Hepatology ; 56(6): 2316-27, 2012 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-22806357

9.

Altered expression and function of hepatic natural killer T cells in obese and diabetic KK-A(y) mice.

Yamagata, Hisafumi; Ikejima, Kenichi; Takeda, Kazuyoshi; Aoyama, Tomonori; Kon, Kazuyoshi; Okumura, Ko; Watanabe, Sumio.

Hepatol Res ; 43(3): 276-88, 2013 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-22834991

10.

Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis.

Inokuchi, Sayaka; Aoyama, Tomonori; Miura, Kouichi; Osterreicher, Christoph H; Kodama, Yuzo; Miyai, Katsumi; Akira, Shizuo; Brenner, David A; Seki, Ekihiro.

Proc Natl Acad Sci U S A ; 107(2): 844-9, 2010 Jan 12.

Artículo en Inglés | MEDLINE | ID: mdl-20080763

11.

Liver function test by gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging with consideration of intrahepatic regional differences.

Okubo, Hironao; Mogami, Miwa; Ozaki, Yutaka; Igusa, Yuki; Aoyama, Tomonori; Amano, Maki; Kokubu, Shigehiro; Miyazaki, Akihisa; Watanabe, Sumio.

Hepatogastroenterology ; 60(127): 1547-51, 2013 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-23933786

12.

Mutation of the 5'-untranslated region stem-loop structure inhibits α1(I) collagen expression in vivo.

Parsons, Christopher J; Stefanovic, Branko; Seki, Ekihiro; Aoyama, Tomonori; Latour, Anne M; Marzluff, William F; Rippe, Richard A; Brenner, David A.

J Biol Chem ; 286(10): 8609-8619, 2011 Mar 11.

Artículo en Inglés | MEDLINE | ID: mdl-21193410

13.

CD1d-restricted natural killer T cells contribute to hepatic inflammation and fibrogenesis in mice.

Ishikawa, Sachiko; Ikejima, Kenichi; Yamagata, Hisafumi; Aoyama, Tomonori; Kon, Kazuyoshi; Arai, Kumiko; Takeda, Kazuyoshi; Watanabe, Sumio.

J Hepatol ; 54(6): 1195-204, 2011 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-21145835

14.

Ursolic acid ameliorates hepatic fibrosis in the rat by specific induction of apoptosis in hepatic stellate cells.

Wang, Xu; Ikejima, Kenichi; Kon, Kazuyoshi; Arai, Kumiko; Aoyama, Tomonori; Okumura, Kyoko; Abe, Wataru; Sato, Nobuhiro; Watanabe, Sumio.

J Hepatol ; 55(2): 379-87, 2011 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-21168456

15.

Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice.

Miura, Kouichi; Kodama, Yuzo; Inokuchi, Sayaka; Schnabl, Bernd; Aoyama, Tomonori; Ohnishi, Hirohide; Olefsky, Jerrold M; Brenner, David A; Seki, Ekihiro.

Gastroenterology ; 139(1): 323-34.e7, 2010 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-20347818

16.

CX3CL1-CX3CR1 interaction prevents carbon tetrachloride-induced liver inflammation and fibrosis in mice.

Aoyama, Tomonori; Inokuchi, Sayaka; Brenner, David A; Seki, Ekihiro.

Hepatology ; 52(4): 1390-400, 2010 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-20683935

17.

Death receptor 5 mediated-apoptosis contributes to cholestatic liver disease.

Takeda, Kazuyoshi; Kojima, Yuko; Ikejima, Kenichi; Harada, Kenichi; Yamashina, Shunhei; Okumura, Kyoko; Aoyama, Tomonori; Frese, Steffen; Ikeda, Hiroko; Haynes, Nicole M; Cretney, Erika; Yagita, Hideo; Sueyoshi, Noriyoshi; Sato, Nobuhiro; Nakanuma, Yasuni; Smyth, Mark J; Okumura, Ko.

Proc Natl Acad Sci U S A ; 105(31): 10895-900, 2008 Aug 05.

Artículo en Inglés | MEDLINE | ID: mdl-18667695

18.

[Liver disease (NAFLD, NASH)].

Aoyama, Tomonori; Watanabe, Sumio.

Nihon Rinsho ; 74 Suppl 2: 460-4, 2016 Apr.

Artículo en Japonés | MEDLINE | ID: mdl-27266135

19.

Diabetic KK-A(y) mice are highly susceptible to oxidative hepatocellular damage induced by acetaminophen.

Kon, Kazuyoshi; Ikejima, Kenichi; Okumura, Kyoko; Arai, Kumiko; Aoyama, Tomonori; Watanabe, Sumio.

Am J Physiol Gastrointest Liver Physiol ; 299(2): G329-37, 2010 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-20539006

20.

Pioglitazone promotes survival and prevents hepatic regeneration failure after partial hepatectomy in obese and diabetic KK-A(y) mice.

Aoyama, Tomonori; Ikejima, Kenichi; Kon, Kazuyoshi; Okumura, Kyoko; Arai, Kumiko; Watanabe, Sumio.

Hepatology ; 49(5): 1636-44, 2009 May.

Artículo en Inglés | MEDLINE | ID: mdl-19205029

BVS CLAP/SMR-OPS/OMS

Centro Latinoamericano de Perinatología, Salud de la Mujer y Reproductiva

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