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1.
6-Azaspiro[2.5]octanes as small molecule agonists of the human glucagon-like peptide-1 receptor.
Bioorg Med Chem Lett
; 94: 129454, 2023 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37591316
2.
Small molecule inhibitors of PCSK9. SAR investigations of head and amine groups.
Bioorg Med Chem Lett
; 92: 129394, 2023 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37379958
3.
Discovery and evaluation of non-basic small molecule modulators of the atypical chemokine receptor CXCR7.
Bioorg Med Chem Lett
; 50: 128320, 2021 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34400299
4.
Discovery of N-(piperidin-3-yl)-N-(pyridin-2-yl)piperidine/piperazine-1-carboxamides as small molecule inhibitors of PCSK9.
Bioorg Med Chem Lett
; 28(23-24): 3685-3688, 2018 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30482620
5.
A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification.
Nat Chem Biol
; 10(8): 629-31, 2014 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-24997604
6.
Identification of a novel conformationally constrained glucagon receptor antagonist.
Bioorg Med Chem Lett
; 24(3): 839-44, 2014 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24418771
7.
The design and synthesis of a potent glucagon receptor antagonist with favorable physicochemical and pharmacokinetic properties as a candidate for the treatment of type 2 diabetes mellitus.
Bioorg Med Chem Lett
; 23(10): 3051-8, 2013 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23562063
8.
Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif.
Bioorg Med Chem Lett
; 23(16): 4571-8, 2013 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23831135
9.
Discovery of a Novel Potent and Selective HSD17B13 Inhibitor, BI-3231, a Well-Characterized Chemical Probe Available for Open Science.
J Med Chem
; 66(4): 2832-2850, 2023 02 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-36727857
10.
Small molecule inhibitors of the Pyk2 and FAK kinases modulate chemoattractant-induced migration, adhesion and Akt activation in follicular and marginal zone B cells.
Cell Immunol
; 275(1-2): 47-54, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-22507871
11.
Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors.
Bioorg Med Chem Lett
; 22(24): 7523-9, 2012 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23153798
12.
The design and synthesis of indazole and pyrazolopyridine based glucokinase activators for the treatment of type 2 diabetes mellitus.
Bioorg Med Chem Lett
; 22(23): 7100-5, 2012 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23089526
13.
Design and synthesis of potent, orally-active DGAT-1 inhibitors containing a dioxino[2,3-d]pyrimidine core.
Bioorg Med Chem Lett
; 21(20): 6122-5, 2011 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21908190
14.
Differences in CYP3A4 catalyzed bioactivation of 5-aminooxindole and 5-aminobenzsultam scaffolds in proline-rich tyrosine kinase 2 (PYK2) inhibitors: retrospective analysis by CYP3A4 molecular docking, quantum chemical calculations and glutathione adduct detection using linear ion trap/orbitrap mass spectrometry.
Bioorg Med Chem Lett
; 19(12): 3177-82, 2009 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19433356
15.
Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): structure-activity relationships and strategies for the elimination of reactive metabolite formation.
Bioorg Med Chem Lett
; 18(23): 6071-7, 2008 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18951788
16.
Small Molecule Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors: Hit to Lead Optimization of Systemic Agents.
J Med Chem
; 61(13): 5704-5718, 2018 07 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29878763
17.
Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK).
J Med Chem
; 61(6): 2372-2383, 2018 03 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-29466005
18.
Optimization of a Dicarboxylic Series for in Vivo Inhibition of Citrate Transport by the Solute Carrier 13 (SLC13) Family.
J Med Chem
; 59(3): 1165-75, 2016 Feb 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-26734723
19.
Expedient Synthesis of N1-Substituted Triazole Peptidomimetics.
ACS Comb Sci
; 17(12): 706-9, 2015 Dec 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-26562078
20.
Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5).
Sci Rep
; 5: 17391, 2015 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26620127