Surgical Predictive Model for Breast Cancer Patients Assessing Acute Postoperative Complications: The Breast Cancer Surgery Risk Calculator.

BACKGROUND: Prognostic tools, such as risk calculators, improve the patient-physician informed decision-making process. These tools are limited for breast cancer patients when assessing surgical complication risk preoperatively. OBJECTIVE: In this study, we aimed to assess predictors associated with acute postoperative complications for breast cancer patients and then develop a predictive model that calculates a complication probability using patient risk factors. METHODS: We performed a retrospective cohort study using the National Surgical Quality Improvement Program (NSQIP) database from 2005 to 2017. Women diagnosed with ductal carcinoma in situ or invasive breast cancer who underwent either breast conservation or mastectomy procedures were included in this predictive modeling scheme. Four models were built using logistic regression methods to predict the following composite outcomes: overall, infectious, hematologic, and internal organ complications. Model performance, accuracy and calibration measures during internal/external validation included area under the curve, Brier score, and Hosmer-Lemeshow statistic, respectively. RESULTS: A total of 163,613 women met the inclusion criteria. The area under the curve for each model was as follows: overall, 0.70; infectious, 0.67; hematologic, 0.84; and internal organ, 0.74. Brier scores were all between 0.04 and 0.003. Model calibration using the Hosmer-Lemeshow statistic found all p-values to be > 0.05. Using model coefficients, individualized risk can be calculated on the web-based Breast Cancer Surgery Risk Calculator (BCSRc) platform ( www.breastcalc.org ). CONCLUSION: We developed an internally and externally validated risk calculator that estimates a breast cancer patient's unique risk of acute complications following each surgical intervention. Preoperative use of the BCSRc can potentially help stratify patients with an increased complication risk and improve expectations during the decision-making process.

Femur flap for tibial reconstruction: percent circumference required to convey a mechanical advantage over the fibula.

The fibula flap is commonly used to reconstruct the tibia. This has risk of postoperative fracture despite long-term non-weight bearing. A flap using noncircumferential distal femur is proposed. This study is to determine the circumference of femur required to produce greater strength than the fibular flap. Femurs and fibulas were harvested from eight cadavers. The structural strength of fibula and femur flaps was assessed using three-point bend. Compression testing was performed on osteotomized and whole femurs to assess donor site morbidity. The 35% flap (mean maximum force at fracture 869 N) was not significantly stronger than the fibula flap (626 N; P > 0.05). The 40% flap (1225 N) was significantly stronger than the fibula flap ( P < 0.01). There was no significant difference between forces at fracture for whole femurs (3978 N), femurs with 35% osteotomies (3604 N), and femurs with 40% osteotomies (3493 N; P = 0.87). Change occurred in the fracture pattern of femurs following osteotomies. Whole femurs consistently fractured at the femoral neck, and osteotomized femurs consistently fractured obliquely from the osteotomy. A flap consisting of 40% of the circumference of the distal femur exceeds the structural strength of the fibular flap. Taking such a flap changes the femur's structural integrity; fixation may be prudent following harvest.

Salvage of a lower extremity by microsurgical transfer of tibial bone from the contralateral extremity traumatically amputated at the ankle level.

The authors present a case of free vascularized transfer of the tibial bone as an osteomyocutaneous flap based on the posterior tibial vessels. A 42-year-old man presented with severe crush injury to bilateral legs. The left tibial bone and soft tissue defect required reconstruction with an osteomyocutaneous free flap. Since the contralateral leg was traumatically amputated at the level of the ankle, a decision was made to harvest a free tibial osteomyocutaneous flap with below-knee-amputation completed. The transfer was achieved successfully with complete survival of the flap and bony union. This report describes the technical and healing aspects of such a unique transfer which may rarely be indicated.

Popliteal vein aneurysm: a case report and review of literature.

The authors report a case of popliteal vein aneurysm (PVA) in a healthy patient who presented with symptoms and review the literature. A 40-year-old healthy male presented with hypoxia secondary to pulmonary emboli. He underwent diagnostic tests revealing a suprageniculate saccular PVA, which was treated by aneurysmectomy and lateral venorrhaphy. A follow-up duplex scan after 18 months showed patent popliteal vein in an asymptomatic patient. A review of 120 cases identified revealed that the most common presentation of PVA is because of thromboembolic complications, often having saccular morphology. Patients were at risk of thromboembolic complications whether intraluminal thrombi were present (63% of the cases) or not. Patients treated with anticoagulation alone had a failure rate of 43%, with thromboembolic complications. Surgical repair of PVA--regardless of the aneurysm size--should be considered in all patients to decrease the risk of thromboembolization.

Characterization of forces on the sternal midline following median sternotomy in a porcine model.

The development of more effective fixation devices for reapproximating and immobilizing the sternum after open-heart surgery is limited by current methods for evaluating these devices. In particular, precise emulation of in vivo sternal loading has not been achieved in controlled model systems. The present study is an initial effort to determine the in vivo loading parameters needed to improve current in vitro and in silico (computational) models. Towards this goal, the direction, magnitude, and distribution of loading along a midline sternotomy were characterized in a porcine model. Two instrumented plating systems were used to measure the forces across the bisected sternum in four anaesthetized Yorkshire pigs during spontaneous breathing, ventilated breathing, and coughing for four treatments: live, cadaveric, embalmed, and refrigerated. Changes in forces incurred by death and embalming were also investigated to evaluate the potential applicability of cadavers as models for testing sternal fixation devices. The magnitudes of the respiratory forces in three orthogonal directions ranged from 0.4 N to 43.8 N, many fold smaller than previously estimated. Dynamic forces were highest in the lateral direction during coughing and low in all directions during normal breathing. No significant differences in force were found between the four treatments, most likely due to the unexpectedly low magnitude of forces in all groups. These results provide the first measurements of in vivo sternal forces and indicate that small cyclic fatigue loads rather than large quasistatic loads should be applied in future model systems to best evaluate the mechanical performance of fixation devices.

Management of incidental fibrous dysplasia of the maxilla in a patient with facial fractures.

We present the case of a 53-year-old man who was involved in a motor vehicle accident. A maxillofacial computed tomography scan revealed a large tumor of the left maxilla as well as multiple facial fractures. The tumor extended from the palate to the orbital floor and from the medial to the lateral wall of the maxillary sinus. We describe the surgical approach as well as the operative management of incidental fibrous dysplasia of the maxilla in a patient with facial fractures.

Venous supercharging of heterodigital artery flap.

BACKGROUND: The heterodigital artery island flap is a popular method of reconstruction for finger defects. Postoperative venous congestion is a common problem. METHODS: The authors present a technique to augment venous drainage of the flap. Briefly, the flap is harvested along with a dorsal vein that is then anastomosed to a recipient vein in an end-to-end fashion, after flap transfer and insetting. Using this technique, seven patients were operated on, ranging in age from 5 to 35 years (average age, 23 years). RESULTS: All flaps survived with no postoperative flap congestion, fully satisfying the reconstructive requirements. By this modification, skeletonization of the digital artery of the flap pedicle is safe if that approach is preferred, since there is no need to harvest periarterial fat for venous drainage. CONCLUSIONS: Providing good harmony with conventional methods and microsurgery, inclusion of a vein with the heterodigital artery island flap allows a more reliable and safer reconstructive choice for finger defects. Such a modification converts the unconventional venous circulation of the heterodigital artery island flap to a more physiologic one.