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1.
First-in-human evaluation of the novel mitochondrial complex I inhibitor ASP4132 for treatment of cancer.
Invest New Drugs
; 39(5): 1348-1356, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33830407
2.
A phase 1 study of oral ASP5878, a selective small-molecule inhibitor of fibroblast growth factor receptors 1-4, as a single dose and multiple doses in patients with solid malignancies.
Invest New Drugs
; 38(2): 445-456, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-31041575
3.
First-in-human, open-label dose-escalation and dose-expansion study of the safety, pharmacokinetics, and antitumor effects of an oral ALK inhibitor ASP3026 in patients with advanced solid tumors.
J Hematol Oncol
; 9: 23, 2016 Mar 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-26966027
4.
BATON-CRC: A Phase II Randomized Trial Comparing Tivozanib Plus mFOLFOX6 with Bevacizumab Plus mFOLFOX6 in Stage IV Metastatic Colorectal Cancer.
Clin Cancer Res
; 22(20): 5058-5067, 2016 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27401244
5.
Dynamic contrast-enhanced magnetic resonance imaging as a biomarker for the pharmacological response of PTK787/ZK 222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases, in patients with advanced colorectal cancer and liver metastases: results from two phase I studies.
J Clin Oncol
; 21(21): 3955-64, 2003 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-14517187
6.
Stereoselective preparation of N-[(R,R)-(E)-1-(3,4-dichlorobenzyl)-3- (2-oxoazepan-3-yl)carbamoyl]allyl-N-methyl-3,5-bis(trifluoromethyl)benzamide, a potent and orally active dual neurokinin NK(1)/NK(2) receptor antagonist.
J Med Chem
; 46(16): 3508-13, 2003 Jul 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-12877589
7.
Clinical potential of respirable antisense oligonucleotides (RASONs) in asthma.
Am J Pharmacogenomics
; 3(2): 97-106, 2003.
Artículo
en Inglés
| MEDLINE | ID: mdl-12749727
8.
Sense and antisense: therapeutic potential of oligonucleotides and interference RNA in asthma and allergic disorders.
Clin Rev Allergy Immunol
; 27(3): 207-17, 2004 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-15630157
9.
A Phase I study of pazopanib in combination with gemcitabine in patients with advanced solid tumors.
Cancer Chemother Pharmacol
; 71(1): 93-101, 2013 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-23064954
10.
A randomized, double-blind, placebo-controlled study to evaluate the effect of repeated oral doses of pazopanib on cardiac conduction in patients with solid tumors.
Cancer Chemother Pharmacol
; 71(3): 565-73, 2013 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-23344712
11.
Phase I study of pazopanib in combination with paclitaxel and carboplatin given every 21 days in patients with advanced solid tumors.
Mol Cancer Ther
; 11(8): 1820-8, 2012 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-22679111
12.
Pazopanib efficacy in renal cell carcinoma: evidence for predictive genetic markers in angiogenesis-related and exposure-related genes.
J Clin Oncol
; 29(18): 2557-64, 2011 Jun 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-21576632
13.
Discovery and development of respirable antisense therapeutics for asthma.
Antisense Nucleic Acid Drug Dev
; 12(3): 177-81, 2002 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-12162700
14.
Biphenyl derivatives as novel dual NK(1)/NK(2)-receptor antagonists.
Bioorg Med Chem Lett
; 12(16): 2065-8, 2002 Aug 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-12127505
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