[Frequency of adverse reactions after influenza vaccination in health care personnel of a university hospital in Spain]. / Frecuencia de reacciones adversas de la vacuna antigripal en personal sanitario de un hospital universitario en España.

INTRODUCTION: One of the reported arguments to health-care personnel receiving influenza vaccination is fear of Adverse Reactions (AR). The objective of this study was to investigate the frequency and characteristics of AR associated with the influenza vaccine. METHODS: Cohort study; 2587 health-care workers vaccinated against influenza during the seasons 2006-2007, 2007-2008 and 2008-2009 were included. They were asked about any AR seven days after the vaccination. RESULTS: A total of 1893 health-care workers were evaluated (73.2%). An AR was reported by 30.3%. There were no serious AR reported. CONCLUSION: The fear of the severity of AR does not seem to be justifiable as a reason for refusing the flu vaccine.

Factors predicting response to hepatitis B vaccination in patients with inflammatory bowel disease.

Hepatitis-B-seronegative patients with inflammatory bowel disease (IBD) should be vaccinated. However, response to vaccination in this population seems to be poorer than in healthy people. The aim of this study is to assess which clinical, analytical and immunosuppressive therapy parameters affect the response to hepatitis B vaccination in patients with IBD. A follow-up including monitoring of the immunosuppressive therapy of a cohort of 123 patients with IBD was carried out after each round of vaccination against hepatitis B virus. The recombinant HBsAg vaccine (20 µg) was administered using the standard regimen (0, 1 and 6 months). Anti-HBs values >10I U/L after 1-3 months post-vaccination were considered as a successful response to vaccination. One hundred and five patients (85.5%) completed the programme and response to vaccination was observed in 50 (47.6%) patients. Multivariate analysis showed an independent relationship, with weaker response to vaccination, for IBD duration equal to or longer than 110 months [adjusted OR (95% CI): 0.282 (0.114-0.701)], serum albumin levels below 3.6 mg/dl at the beginning of vaccination [adjusted OR (95% CI): 0.336 (0.112-1.009)], and corticosteroid therapy in more than one vaccination dose [adjusted OR (95% CI): 0.333 (0.135-0.820)]. This study confirms the poor response to hepatitis B vaccination in patients with IBD, being particularly weak in individuals with long-term IBD progression, low serum albumin levels and those on corticosteroid therapy.

Frecuencia de reacciones adversas de la vacuna antigripal en personal sanitario de un hospital universitario en España / Frequency of adverse reactions after influenza vaccination in health care personnel of a university hospital in Spain

Introducción Entre los argumentos del trabajador sanitario para no vacunarse de gripe está el temor a reacciones adversas (RA). El objetivo fue estudiar la frecuencia y las características de tales reacciones. Métodos Estudio de cohortes que incluyó a los 2.587 trabajadores vacunados en las temporadas (..) (AU)

Introduction One of the reported arguments to health-care personnel receiving influenza vaccination is fear of Adverse Reactions (AR). The objective of this study was to investigate the frequency and characteristics of AR associated with the influenza (..) (AU)

Frecuencia de reacciones adversas de la vacuna antigripal en personal sanitario de un hospital universitario en España / Frequency of adverse reactions after influenza vaccination in health care personnel of a university hospital in Spain

Introducción Entre los argumentos del trabajador sanitario para no vacunarse de gripe está el temor a reacciones adversas (RA). El objetivo fue estudiar la frecuencia y las características de tales reacciones. Métodos Estudio de cohortes que incluyó a los 2.587 trabajadores vacunados en las temporadas 2006–2007, 2007–2008 y 2008–2009. Para detectar RA se contactó con el trabajador una semana después de la vacunación. Esultados Se evaluaron 1.893 trabajadores (73,2%). El 30,3% sufrió alguna RA. Ninguna reacción fue grave. Conclusiones El temor a la gravedad de las RA no parece justificable como motivo de rechazo a la vacuna antigripal (AU)

Introduction One of the reported arguments to health-care personnel receiving influenza vaccination is fear of Adverse Reactions (AR). The objective of this study was to investigate the frequency and characteristics of AR associated with the influenza vaccine. Methods Cohort study; 2587 health-care workers vaccinated against influenza during the seasons 2006–2007, 2007–2008 and 2008–2009 were included. They were asked about any AR seven days after the vaccination. Results A total of 1893 health-care workers were evaluated (73.2%). An AR was reported by 30.3%. There were no serious AR reported. Conclusion The fear of the severity of AR does not seem to be justifiable as a reason for refusing the flu vaccine (AU)