An evaluation of the safety and immunogenicity of MVC-COV1901: Results of an interim analysis of a phase III, parallel group, randomized, double-blind, active-controlled immunobridging study in Paraguay.

BACKGROUND: Data from previous studies of the MVC-COV1901 vaccine, a subunit vaccine against SARS-CoV-2 based on the stable prefusion spike protein (S-2P) adjuvanted with CpG 1018 adjuvant and aluminum hydroxide, suggest that the vaccine is generally safe and elicits a good immune response in healthy adults and adolescents. By comparing with AZD1222, this study adds to the findings from previous trials and further evaluates the breadth of protection offered by MVC-COV1901. METHODS: In this phase 3, parallel group, randomized, double-blind, active-controlled trial conducted in 2 sites in Paraguay, we assigned adults aged 18-91 years in a 1:1 ratio to receive intramuscular doses of MVC-COV1901 or AZD1222 administered as scheduled in the clinical trial. Serum samples were collected on the day of vaccination and 14 days after the second dose. Primary and secondary safety and immunogenicity endpoints were assessed. In addition, other outcomes investigated were cross-reactive immunity against the Omicron strain and the induction of IgG subclasses. RESULTS: A total of 1,030 participants underwent randomization. Safety data was derived from this set while primary immunogenicity data involved a per-protocol immunogenicity (PPI) subset including 225 participants. Among the participants, 58% are seropositive at baseline. When compared against AZD1222, MVC-COV1901 exhibited superiority in terms of neutralizing antibody titers and non-inferiority in terms of seroconversion rates. Reactogenicity was generally mild and no serious adverse event was attributable to MVC-COV1901. Both vaccines have a Th1-biased response predominated by the production of IgG1 and IgG3 subclasses. Omicron-neutralizing titers were 44.5 times lower compared to wildtype-neutralizing titers among seronegative individuals at baseline. This fold-reduction was 3.0 times among the seropositive. CONCLUSION: Safety and immunogenicity data of MVC-COV1901 from the study in Paraguay confirm previous results. The previous infection coupled with vaccination of this vaccine may offer protection against the Omicron strain though its durability is still unknown.

Informes seguimiento a egresados de la Facultad de Ciencias Médicas de la Universidad Nacional de Asunción carrera de Medicina y Cirugía sede Asunción cohorte 2010 al 2017 / Follow-up reports to graduates of the Faculty of Medical Sciences of the National University of Asunción, Medicine and Surgery degree, Asunción cohort 2010 to 2017

Introducción: Considerando la Ley de la Nación Paraguaya 4995/2013 "De Educación Superior", en su artículo 82°, establece que "la Agencia Nacional de Evaluación y Acreditación de la Educación Superior (ANEAES) es el organismo técnico encargado de evaluar y acreditar la calidad académica de los Institutos de Educación Superior". Por Resolución N°08/07 del Consejo Directivo de la ANEAES de fecha 17 de diciembre de 2007 aprueba los criterios de calidad para la carrera de medicina, donde en la dimensión 5, componente "egresados" establece: La carrera debe velar por el cumplimiento de las metas establecidas en cuanto a duración real de la carrera, logro del perfil de egreso e inserción de sus egresados en el mercado laboral. A los efectos se deberá establecer y aplicar mecanismos de consulta a los egresados para determinar su grado de satisfacción y retroalimentar el proceso formativo y los planes de mejora. Objetivos: contribuir a obtener información de la situación laboral y formación académica que permitan evaluar la calidad de la educación superior brindada y proponer mecanismos que contribuyan a la mejora del desempeño profesional de los egresados. Materiales y métodos: Los datos fueron procesados utilizando estadística descriptiva para todas las variables. El Instrumento utilizado es un Cuestionario conformado por 63 preguntas divididas en 5 secciones. Se contactó con los egresados por llamadas telefónicas y mensajería instantánea. Resultados: Durante los años 2010-2017, egresaron 984 profesionales. Total, de Encuestados: 133 egresados, siendo 73 mujeres (55%) y 60 hombres (45%). El 25 % de los egresados que han respondido la encuesta consideran que la formación académica recibida es excelente, el 44% considera que es muy buena, el 23% que es buena, el 6% regular y el 2% considera que es mala. Conclusión: El nivel de inserción laboral es alto al momento del egreso. La Satisfacción con la formación académica recibida es muy buena, con recomendaciones viables para el plan de mejoras en el programa de estudio

Introduction: Considering the Law of the Paraguayan Nation 4995/2013 "On Higher Education", in its article 82°, establishes that "the National Agency for the Evaluation and Accreditation of Higher Education (ANEAES) is the technical body in charge of evaluating and accrediting the academic quality of the Institutes of Higher Education". By Resolution N ° 08/07 of the Board of Directors of the ANEAES dated December 17, 2007, it approves the quality criteria for the medical career, where in dimension 5, the "graduates" component, it establishes: The career must ensure compliance of the goals established in terms of real duration of the career, achievement of the graduation profile and insertion of its graduates in the labor market. For this purpose, consultation mechanisms must be established and applied to graduates to determine their degree of satisfaction and provide feedback on the training process and improvement plans. Objectives: The objective of this follow-up report was to obtain useful information on the employment situation and academic training that allow evaluating the quality and relevance of the higher education provided and proposing mechanisms that contribute to the improvement of the professional performance of graduates. Materials and methods: The data were processed using descriptive statistics for all variables. The Instrument used is a Questionnaire made up of 63 questions divided into 5 sections. Graduates were contacted by phone calls and instant messaging. Results: During the years 2010-2017, 984 professionals graduated. Total of Respondents: 133 graduates, being 73 women (55%) and 60 men (45%). 25% of the graduates who responded to the survey consider that the academic training received is excellent, 44% consider it very good, 23% that it is good, 6% fair and 2% consider that it is bad. Conclusion: The level of labor insertion is high at the time of graduation. Satisfaction with the academic training received is very good, with viable recommendations for the improvement plan in the study program

Two-dimensional ultrasonic strain rate measurement of the human heart in vivo.

A study is presented in which the feasibility of two-dimensional strain rate estimation of the human heart in vivo has been demonstrated. To do this, ultrasonic B-mode data were captured at a high temporal resolution of 3.8 ms and processed off-line. The motion of the RF signal patterns within the two-dimensional sector image was tracked and used as the basis for strain rate estimation. Both axial and lateral motion and strain rate estimates showed a good agreement with the results obtained by more established, one-dimensional techniques.

Inserción laboral de los egresados de la Carrera de Medicina y Cirugía de la Facultad de Ciencias Médicas de la Universidad Nacional de Asunción, cohortes 2010-2012 / Labor insertion of Medicine and Surgery graduates of the School of Medical Sciences of the National University of Asunción, cohorts 2010-2012

Introducción: Una manera de evaluar el resultado y la pertinencia de un plan de estudios es a través del seguimiento de egresados, siendo esta una tarea fundamental en la gestión de una institución de educación superior. Objetivo: El objetivo del presente informe de seguimiento fue conocer la inserción laboral de los egresados de la Carrera de Medicina y Cirugía de la Facultad de Ciencias Médicas de la Universidad Nacional de Asunción. Metodología: Se solicitó al Departamento de Informática Académica la lista de egresados de la Carrera de Medicina y Cirugía de las cohortes 2010-212. A fin de obtener datos de aquellos egresados que se encontraban trabajando en el sector público se recurrió a la página Web Portal Paraguay. A los profesionales no ubicados en el sector público se les contactó vía telefónica. Resultados: Durante los años 2010-2012, egresaron 355 profesionales (172 mujeres y 183 varones). La mayoría de los egresados se encuentra trabajando en el sector público, esto es: 64% de los egresados de la cohorte de 2010; 63% de la cohorte 2011; y 74% de la cohorte 2012. 11% (año 2010), 5% (año 2011) y 3% (año 2012) de los egresados se encuentran en el extranjero. Discusión: Es recomendable crear la Unidad de Seguimiento a Egresados, que podría depender de la Dirección de Aseguramiento de la Calidad Académica y trabajar en estrecha colaboración con la Dirección de Postgrado, la Dirección Académica y la Dirección del Hospital de Clínicas. Esta Unidad podría dar continuidad a los programas de seguimiento de egresados y de valoración del impacto que tienen los mismos en la salud, la ciencia y la enseñanza de la ciencia médica a nivel local y regional.

Introduction: One way to assess the result and the relevance of a curriculum is through the follow-up of graduates. This is a fundamental task in the management of a higher education institution. Objective: The objective of the present follow-up report was to know and monitor the labor insertion of graduates of the Medicine and Surgery Career of the School of Medical Sciences, National University of Asunción. Methodology: The Department of Academic Informatics was asked for the list of graduates of the Medicine and Surgery Career of the 2010-212 cohorts. In order to obtain data from those graduates who were working in the public sector, the Paraguay Portal website was used. Professionals not located in the public sector were contacted by telephone. Results: During the years 2010-2012, 355 professionals (172 women and 183 men) graduated. The majority of the graduates are working in the public sector, that is: 64% of the graduates of the 2010 cohort; 63% of the 2011 cohort; and 74% of the cohort 2012. 11% (year 2010), 5% (year 2011) and 3% (year 2012) of the graduates are abroad. Discussion: It is advisable to create the Unit for the Follow-up of graduates, which could depend on the Academic Quality Assurance Department and work in close collaboration with the Postgraduate Department, the Academic Department and with the Hospital of Clínicas Management Department. This Unit could give continuity to graduate follow-up programs and to assess the impact graduates have on health, science and medical science education at the local and regional level.

Angioplastia percutanea transluminal coronaria: implantación de stent metalico coronario

El trabajo estudia la posibilidad de la implantación de stent coronario en nuestro medio, compara los resultados de la angioplastia coronaria con balon y la combinación del procedimiento de angioplastia con balon y stent y hace una revisión sobre el stent en el momento actual