RESUMEN
Focal epithelial hyperplasia (FEH) or Heck disease, is a rare viral infection of the oral mucosa caused by HPV 13 or HPV 32. In Caucasians there have been only a few cases reported. We present the first case in Greece in a young Caucasian girl in which HPV 13 was detected with PCR analysis. The patient was successfully treated with CO2 laser.
Asunto(s)
Hiperplasia Epitelial Focal/radioterapia , Terapia por Láser , Papillomaviridae/aislamiento & purificación , Infecciones por Papillomavirus/radioterapia , Infecciones Tumorales por Virus/radioterapia , Adolescente , Dióxido de Carbono , ADN Viral/aislamiento & purificación , Femenino , Hiperplasia Epitelial Focal/patología , Humanos , Papillomaviridae/genética , Infecciones por Papillomavirus/patología , Reacción en Cadena de la Polimerasa , Infecciones Tumorales por Virus/patologíaRESUMEN
Two cases of fixed drug eruption, occurring in a mother and son, are presented. The eruption in the mother occurred after she ingested dimenhydrinate or acetylsalicylic acid and in the son after ingestion of either of the above drugs or with "junk" food (cheese crisps). Apart from the drugs, anxiety was found to be an essential factor in the manifestation of the mother's disease. A genetic predisposition would seem to link these cases.
Asunto(s)
Erupciones por Medicamentos/etiología , Adulto , Ansiedad/complicaciones , Aspirina/efectos adversos , Niño , Dimenhidrinato/efectos adversos , Erupciones por Medicamentos/genética , Hipersensibilidad a los Alimentos/complicaciones , Humanos , Masculino , RecurrenciaRESUMEN
We present a patient with atrophodermia vermiculata. A family tree study revealed an autosomal mode of inheritance with good penetrance. A slight improvement of the atrophic scars of the disease was noticed after local treatment with tretinoin cream, 0.05 percent, and cryotherapy.
Asunto(s)
Dermatosis Facial/genética , Administración Cutánea , Atrofia/patología , Niño , Cicatriz/etiología , Cicatriz/patología , Crioterapia , Epidermis/patología , Eritema/etiología , Eritema/patología , Dermatosis Facial/patología , Dermatosis Facial/terapia , Humanos , Masculino , Linaje , Tretinoina/administración & dosificaciónRESUMEN
The authors undertook a clinical and genetic study in a large family with the aim of identifying the mode of inheritance of Fabry syndrome and congenital ptosis. These two types of pathology were present to varying extents. The family pedigree consisted of 95 individuals, spanning 5 generations. Three individuals (males) were found to have Fabry syndrome and 14 (males and females) congenital ptosis. The patients with Fabry syndrome also had congenital ptosis. According to these results, Fabry syndrome is inherited by an X-linked recessive mode and congenital ptosis by an autosomal dominant mode.
Asunto(s)
Blefaroptosis/genética , Enfermedad de Fabry/genética , Blefaroptosis/complicaciones , Blefaroptosis/congénito , Enfermedad de Fabry/complicaciones , Femenino , Humanos , Masculino , LinajeRESUMEN
Twenty eight human cases of orf were studied from clinical and epidemiological points of view. Most of the patients were shepherds who were inoculated from infected animals during all seasons of the year. Typical lesions of different stages of orf were located on the hands, and were accompanied by local symptoms such as pain, pruritus, lymphangitis and adenitis, or less frequently by systemic symptoms such as fever or malaise. Two cases developed erythema multiforme, one developed erysipelas and another a papulovesicular eruption. Tzanck test may contribute to the diagnosis. The course of the disease can not be influenced by antibiotics, and only measures of local hygiene are recommended, except in complicated cases.
Asunto(s)
Ectima Contagioso/diagnóstico , Enfermedades Profesionales/diagnóstico , Adolescente , Adulto , Anciano , Animales , Ectima Contagioso/epidemiología , Ectima Contagioso/transmisión , Femenino , Humanos , Labio/patología , Masculino , Persona de Mediana Edad , Enfermedades Profesionales/epidemiología , Ovinos , Piel/patologíaRESUMEN
Two further methods for the characterization of epidermal skin tumors are described: the antinuclear antibody (ANA) immunofluorescent test, which consists of indirect immunofluorescence with known high titer sera containing homogenous ANAs on epidermal skin tumors, and the ammoniacal-silver cytochemical method, which specifically stains nuclear histones. Squamous cell carcinomas (SCCs), basal cell epitheliomas (BCEs) as well as control specimens from normal skin and benign epidermal hyperplasias were studied. The ANA immunofluorescent test was positive for most SCCs, mixed SCC and basal cell carcinomas and metatypical BCEs. The ammoniacal-silver method gave a characteristic staining pattern shared among SCCs, mixed carcinomas and metatypical BCEs. BCEs, besides metatypical ones, were always negative by the ANA immunofluorescent test and the same applied for the control specimens. The ammoniacal-silver method gave a characteristic staining pattern for BCEs and control sections quite different from the staining pattern of the more aggressive forms of epidermal tumors. The two methods usually yielded parallel results.
Asunto(s)
Carcinoma Basocelular/patología , Carcinoma de Células Escamosas/patología , Neoplasias Cutáneas/patología , Piel/patología , Anticuerpos Antinucleares/análisis , Diagnóstico Diferencial , Técnica del Anticuerpo Fluorescente , Histonas/análisis , Humanos , Plata , Coloración y EtiquetadoRESUMEN
Linear scleroderma is an unusual form of localised scleroderma, mainly affecting the legs and occurring primarily in children. Sometimes the linear lesions may extend to involve the underlying muscles and bones, with severe disturbances in growth and possibly flexion deformities of the legs. In this study, two cases suffering from linear scleroderma of the legs are presented.