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1.
Straightforward Synthesis of Bis[(trifluoromethyl)sulfonyl]ethylated Isocoumarins from 2-Ethynylbenzoates.
J Org Chem
; 88(11): 7373-7380, 2023 Jun 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-37133251
2.
N-Hydroxy-N-Propargylamide Derivatives of Ferulic Acid: Inhibitors of Cholinesterases and Monoamine Oxidases.
Molecules
; 27(21)2022 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36364263
3.
Tacrines as Therapeutic Agents for Alzheimer's Disease. V. Recent Developments.
Chem Rec
; 21(1): 162-174, 2021 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-33169934
4.
Acetylcholinesterase Inhibition of Diversely Functionalized Quinolinones for Alzheimer's Disease Therapy.
Int J Mol Sci
; 21(11)2020 May 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-32486316
5.
Triazolopyridopyrimidine: A New Scaffold for Dual-Target Small Molecules for Alzheimer's Disease Therapy.
Molecules
; 25(14)2020 Jul 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-32668671
6.
Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases.
Angew Chem Int Ed Engl
; 56(41): 12765-12769, 2017 10 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-28861918
7.
Synthesis and Biological Evaluation of Benzochromenopyrimidinones as Cholinesterase Inhibitors and Potent Antioxidant, Non-Hepatotoxic Agents for Alzheimer's Disease.
Molecules
; 21(5)2016 May 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-27187348
8.
Predicting targets of compounds against neurological diseases using cheminformatic methodology.
J Comput Aided Mol Des
; 29(2): 183-98, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25425329
9.
In Vitro and In Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases.
ACS Chem Neurosci
; 11(22): 3793-3801, 2020 11 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-33143412
10.
Label-Free Whole Cell Biosensing for High-Throughput Discovery of Activators and Inhibitors Targeting G Protein-Activated Inwardly Rectifying Potassium Channels.
ACS Omega
; 3(11): 14814-14823, 2018 Nov 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-30555990
11.
Contilisant, a Tetratarget Small Molecule for Alzheimer's Disease Therapy Combining Cholinesterase, Monoamine Oxidase Inhibition, and H3R Antagonism with S1R Agonism Profile.
J Med Chem
; 61(15): 6937-6943, 2018 Aug 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-29969030
12.
N-Benzylpiperidine Derivatives as α7 Nicotinic Receptor Antagonists.
ACS Chem Neurosci
; 7(8): 1157-65, 2016 08 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-27254782
13.
Synthesis and Biological Assessment of Racemic Benzochromenopyrimidinimines as Antioxidant, Cholinesterase, and Aß1-42 Aggregation Inhibitors for Alzheimer's Disease Therapy.
ChemMedChem
; 11(12): 1318-27, 2016 Jun 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-26804623
14.
The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators.
J Med Chem
; 59(21): 9967-9973, 2016 11 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-27736061
15.
Development of HuperTacrines as non-toxic, cholinesterase inhibitors for the potential treatment of Alzheimer's disease.
Mini Rev Med Chem
; 15(8): 648-58, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-25694076
16.
Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids.
Drug Des Devel Ther
; 8: 1893-910, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25378907
17.
Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.
Eur J Med Chem
; 75: 82-95, 2014 Mar 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-24530494
18.
N-Methyl-N-((1-methyl-5-(3-(1-(2-methylbenzyl)piperidin-4-yl)propoxy)-1H-indol-2-yl)methyl)prop-2-yn-1-amine, a new cholinesterase and monoamine oxidase dual inhibitor.
J Med Chem
; 57(24): 10455-63, 2014 Dec 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-25418133
19.
Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.
Eur J Med Chem
; 80: 543-61, 2014 Jun 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-24813882
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