[ARTIFICIAL INTELLIGENCE IN OPHTHALMOLOGY].

INTRODUCTION: Artificial intelligence (AI) was first introduced in 1956, and effectively represents the fourth industrial revolution in human history. Over time, this medium has evolved to be the preferred method of medical imagery interpretation. Today, the implementation of AI in the medical field as a whole, and the ophthalmological field in particular, is diverse and includes diagnose, follow-up and monitoring of the progression of ocular diseases. For example, AI algorithms can identify ectasia, and pre-clinical signs of keratoconus, using images and information computed from various corneal maps. Machine learning (ML) is a specific technique for implementing AI. It is defined as a series of automated methods that identify patterns and templates in data and leverage these to perform predictions on new data. This technology was first applied in the 1980s. Deep learning is an advanced form of ML inspired by and designed to imitate the human brain process, constructed of layers, each responsible for identifying patterns, thereby successfully modeling complex scenarios. The significant advantage of ML in medicine is in its' ability to monitor and follow patients with efficiency at a low cost. Deep learning is utilized to monitor ocular diseases such as diabetic retinopathy, age-related macular degeneration, glaucoma, cataract, and retinopathy of prematurity. These conditions, as well as others, require frequent follow-up in order to track changes over time. Though computer technology is important for identifying and grading various ocular diseases, it still necessitates additional clinical validation and does not entirely replace human diagnostic skill.

[CONTACT LENS COMPLICATIONS].

INTRODUCTION: This article will review the complications of contact lenses (CL) according to the literature over the past few years including mechanical, inflammatory, allergic, toxic, metabolic, and infectious complications. There are CL complications that are not sight-threatening and there are severe complications that do threaten the sight. In general, any complication from CL that involves the cornea may endorse irreversible damage to sight. Most of the complications that involve the cornea are complications due to infectious backgrounds and are the most severe amongst CL wearers. The more continuous the CL wear is, the greater the danger to develop a complication. In the past it was assumed that switching from hydrogel CL to silicone hydrogel CL would reduce the incidence of CL complications, but this was not the case. From the point of view of wearing habits, the use of reusable CL (weekly or monthly) produced from more advanced raw materials did not reduce the percentage of complications. The complication may be due to incorrect CL compliance, incorrect use of the disinfecting solutions, incorrect compliance and cleaning of the CL. CL wearers aged between 15 to 19 years are the largest risk group to develop complications. Amongst younger aged wearers there is more precision due to parent supervision. The purchase of CL on-line has increased the percentage of complications because the patient purchasing the CL on-line does not attribute importance to the periodic examination by the professional eye therapist.

[COMPUTER VISION SYNDROME].

INTRODUCTION: Computer vision syndrome (CVS) is a very common phenomenon amongst computer users. A total of 90% of computer users, who spend more than 3 hours a day in front of the computer screen, suffer from CVS. CVS is also known as digital eye strain or visual fatigue and includes symptoms that are a result of continuous work in front of the different types of computer screens or other types of digital screens. An updated differentiation divides the cause of the symptoms into three separate categories which include visual symptoms, symptoms resulting from the digital screen itself and symptoms resulting from the ocular surface. CVS includes a wide range of symptoms which are non-specific (asthenopia), which include eye fatigue, eye strain, pain in and around the eye, blurred vision, headaches and even diplopia (double vision). Asthenopia and dry eye are the core symptoms of CVS. There are many solutions and ways to treat the different symptoms related to the vision, the screen and ocular surface and especially the symptoms related to the issue of dry eye. The treatment of CVS is focused around the different groups of symptoms and it is recommended to give a combined treatment for all the symptomatic groups. The correction of residual astigmatism, accommodation issues, base-in or base-up prisms and the correction of vergence reserves to maintain vision aspects. Changing the lighting, correct positioning of the screen and correcting the direction of gaze in relation to symptoms which are connected to the screen and artificial tears, as well as increasing the blink rate and increasing the level of moisture of the air in the room, all assist in treating the symptoms of dry eye. Blue light also has some effect on CVS and as a precaution it is recommended to reduce, as much as possible, blue light radiation that enters the eye or is emitted from the computer screen.

Exemplifying practice-based research: the influence of age on myopia progression.

CLINICAL RELEVANCE: The electronic storage of patient records and modern-day search engines present private practitioners with a unique opportunity to extract valuable data for investigative research purposes. However, practitioners seldom harness this resource and consequently a vast repository of clinical data remains largely unexplored. BACKGROUND: This study, based on real-world data from an optometric practice, stands as an example of how clinicians can actively contribute to research. In doing so it underscores the role played by age in determining the rate of natural myopia progression. METHODS: A retrospective data analysis of the refractive status, age and optical correction type of participants, was conducted over six years. Forty-four participants were recruited (25 contact lens and 19 spectacle wearers), with a presenting age varying from 5 to 20 years (median, 11 years). Non-cycloplegic, monocular foveal refractions were completed using a ShinNippon open-field autorefractor, corroborated with subjective refraction. The mean spherical equivalent refractive error was calculated for the participants' initial visit (baseline measure) and for a six-year follow-up visit (progression measure), with myopia progression defined as the difference between these measures. Statistical analyses were computed using Decision Tree Analysis, with a significance level set at 95%. RESULTS: The participant age at first visit exerted a significant influence on natural myopia progression over the assessment period (F 1,42 = 17.11, p < 0.001). Individuals aged ≤ 10 years had approximately twice the myopic progression (mean, -2.27 D) of those aged > 10 years (mean, -1.13 D). Neither degree of myopia at the initial visit nor optical correction type had a significant effect on progression (p > 0.05). CONCLUSIONS: Utilizing the advantage of small real-world data samples, the benefit of research by private practitioners was demonstrated, providing evidence that the age at which a child first presents for an eye examination is highly influential in determining their rate of myopia progression.

BCLA CLEAR Presbyopia: Evaluation and diagnosis.

It is important to be able to measure the range of clear focus in clinical practice to advise on presbyopia correction techniques and to optimise the correction power. Both subjective and objective techniques are necessary: subjective techniques (such as patient reported outcome questionnaires and defocus curves) assess the impact of presbyopia on a patient and how the combination of residual objective accommodation and their natural DoF work for them; objective techniques (such as autorefraction, corneal topography and lens imaging) allow the clinician to understand how well a technique is working optically and whether it is the right choice or how adjustments can be made to optimise performance. Techniques to assess visual performance and adverse effects must be carefully conducted to gain a reliable end-point, considering the target size, contrast and illumination. Objective techniques are generally more reliable, can help to explain unexpected subjective results and imaging can be a powerful communication tool with patients. A clear diagnosis, excluding factors such as binocular vision issues or digital eye strain that can also cause similar symptoms, is critical for the patient to understand and adapt to presbyopia. Some corrective options are more permanent, such as implanted inlays / intraocular lenses or laser refractive surgery, so the optics can be trialled with contact lenses in advance (including differences between the eyes) to better communicate with the patient how the optics will work for them so they can make an informed choice.

Peripheral Defocus and Myopia Management: A Mini-Review.

Myopia is the most common refractive error in the world, and its' prevalence continually increases. The potential pathological and visual complications of progressive myopia have inspired researchers to study the sources of myopia, axial elongation, and explore modalities to arrest progression. Considerable attention has been given over the past few years to the myopia risk factor known as hyperopic peripheral blur, the focus of this review. The primary theories currently believed to be the cause of myopia, the parameters considered to contribute and influence the effect of peripheral blur, such as the surface retinal area or depth of blur will be discussed. The currently available optical devices designed to provide peripheral myopic defocus will be discussed, including bifocal and progressive addition ophthalmic lenses, peripheral defocus single vision ophthalmic lenses, orthokeratology lenses, and bifocal or multifocal center distance soft lenses, as well as their effectivity as mentioned in the literature to date.

Peripheral defocus as it relates to myopia progression: A mini-review.

Myopia is the most common refractive error in the world and has reached a pandemic level. The potential complications of progressive myopia have inspired researchers to attempt to understand the sources of myopia and axial elongation and to develop modalities to arrest progression. Considerable attention has been given over the past few years to the myopia risk factor known as hyperopic peripheral blur, which is the focus of this review. It will discuss the primary theories believed to be the cause of myopia and the parameters considered to contribute to and influence the effect of peripheral blur, such as the surface retinal area of blur or the depth of blur. The multitude of optical devices designed to provide peripheral myopic defocus will be mentioned, including bifocal and progressive addition ophthalmic lenses, peripheral defocus single-vision ophthalmic lenses, orthokeratology lenses, and bifocal or multifocal center distance soft lenses, as well as their effectivity as discussed in the literature to date.

The effect of contact lens wear on retinal spectral domain optical coherence tomography.

BACKGROUND: This study assessed the impact of contact lens wear on retinal spectral domain optical coherence tomography (SD-OCT) image quality and macular thickness measurements, among subjects with myopia. METHODS: This was a prospective study including 34 subjects (26.59 ± 3.19 years) with myopia or myopic astigmatism. Twelve were imaged wearing spherical soft contact lenses, eight non-contact lens wearers were imaged with a plano soft contact lens, and 14 with significant astigmatism were fitted with a rigid gas permeable (RGP) contact lens. For each group of contact lens types, the average image quality index (Q-index), and the average macular thickness measurements were compared between macular OCT scans obtained from the same eyes with and without a contact lens. RESULTS: Among the subjects assessed with their habitual spherical soft lenses, the average Q-index was similar for scans acquired with and without a contact lens (30.10 ± 1.94 versus 31.03 ± 2.55; p = 0.18). Among non-contact lens wearers, the average Q-index was slightly higher for scans acquired without a contact lens, compared to scans with a plano contact lens (31.99 ± 2.06 versus 29.51 ± 1.56; p = 0.006). Among 14 subjects imaged wearing a fitted RGP contact lens, the Q-index was similar for scans acquired with and without a contact lens (29.04 ± 2.73 versus 28.75 ± 2.86; p = 0.78). In all groups, there were no correlations between the power of the sphere and change in the Q-index (that is, post- minus pre-contact lens Q-index), and no differences were found between OCT-derived macular thickness measurements from scans with and without a contact lens. The magnitude of cylinder was not correlated with the change in the Q-index in the habitual and RGP contact lens groups. However, an inverse correlation between cylinder power and change in the Q-index was found in the plano contact lens group. CONCLUSION: In low to intermediate levels of myopia, with or without regular astigmatism, macular SD-OCT imaging does not merit placement of a soft or rigid contact lens, nor is there an added benefit from removing a habitual spherical soft lens prior to scanning.