Low-Field MRI of Stroke: Challenges and Opportunities.

Stroke is a leading cause of death and disability worldwide. The reasons for increased stroke burden in developing countries are inadequately controlled risk factors resulting from poor public awareness and inadequate infrastructure. Computed tomography and MRI are common neuroimaging modalities used to assess stroke with diffusion-weighted MRI, in particular, being the recommended choice for acute stroke imaging. However, access to these imaging modalities is primarily restricted to major cities and high-income groups. In the case of stroke, the time-window of treatment to limit the damage is of a few hours and needs a point-of-care diagnosis. A low-cost MR system typically achieved at the ultra-low- and very-low-field would meet the need for a geographically accessible and portable solution. We review studies focused on accessible stroke imaging and recent developments in MR methodologies, including hardware, to image at low fields. We hypothesize that in the absence of a formal, rapid stroke triaging system, the value of timely on-site delivery of the scanner to the stroke patient can be significant. To this end, we discuss multiple recent hardware and methods developments in the low-field regime. Our review suggests a compelling need to explore further the trade-offs between high signal, contrast, and accessibility at low fields in low-income communities. LEVEL OF EVIDENCE: 4 TECHNICAL EFFICACY STAGE: 6.

Deep Learning-Based Denoising for High b-Value at 2000 s/mm2 Diffusion-Weighted Imaging.

Diffusion-weighted imaging (DWI) allows white matter quantification of the white matter tracts of the brain. However, at a high b-value (≥ 2000 s/mm2), DWI acquisition suffers from noise due to longer acquisition times obscuring white matter interpretation. DWI denoising techniques can be used to acquire high b-value DWI without increasing the number of signal averages. We used a residual learning-based convolutional neural network (DnCNN) to reduce noise in high b-value DWI based on the literature review. We applied the proposed denoising method on high b-value, retrospectively collected DWI data with multiple noise levels. Experimental results show an improved image quality after denoising in retrospective DWI (average PSNR before and after denoising: 27.63 ± 1.06 dB and 51.76 ± 1.95 dB, respectively). The prospective DWI included one and two signal averages for denoising. DWI with four signal averages was used as the reference. Representative images show high b-value prospective DW images denoised using the DnCNN. We demonstrated DnCNN for cases of multiple noise levels and signal averages. For the prospective study, the PSNR values for 1-NEX before and after denoising were 27.39 ± 3.75 dB and 27.68 ± 3.75 dB. For 2-NEX, the PSNR values before and after denoising were 27.51 ± 4.18 dB and 27.75 ± 4.05 dB.