The CNDR: collaborating to translate new therapies for Canadians.

BACKGROUND: Patient registries represent an important method of organizing "real world" patient information for clinical and research purposes. Registries can facilitate clinical trial planning and recruitment and are particularly useful in this regard for uncommon and rare diseases. Neuromuscular diseases (NMDs) are individually rare but in aggregate have a significant prevalence. In Canada, information on NMDs is lacking. Barriers to performing Canadian multicentre NMD research exist which can be overcome by a comprehensive and collaborative NMD registry. METHODS: We describe the objectives, design, feasibility and initial recruitment results for the Canadian Neuromuscular Disease Registry (CNDR). RESULTS: The CNDR is a clinic-based registry which launched nationally in June 2011, incorporates paediatric and adult neuromuscular clinics in British Columbia, Alberta, Ontario, Quebec, New Brunswick and Nova Scotia and, as of December 2012, has recruited 1161 patients from 12 provinces and territories. Complete medical datasets have been captured on 460 "index disease" patients. Another 618 "non-index" patients have been recruited with capture of physician-confirmed diagnosis and contact information. We have demonstrated the feasibility of blended clinic and central office-based recruitment. "Index disease" patients recruited at the time of writing include 253 with Duchenne and Becker muscular dystrophy, 161 with myotonic dystrophy, and 71 with ALS. CONCLUSIONS: The CNDR is a new nationwide registry of patients with NMDs that represents an important advance in Canadian neuromuscular disease research capacity. It provides an innovative platform for organizing patient information to facilitate clinical research and to expedite translation of recent laboratory findings into human studies.

Age-related health risk behaviors of adolescents with physical disabilities.

OBJECTIVE: To investigate age-related differences in health risk behaviors in 11-12-, 13-14-, and 15-16-year-old adolescents with physical disabilities. METHOD: Health survey data from 319 adolescents with physical disabilities were compared with the same data from 7,020 adolescents in a national sample. RESULTS: Significant age-related differences were found for having tried smoking, smoking, having tasted an alcoholic drink, having been drunk, and using prescription drugs for recreational purposes. However, changes were modest and engagement of 15-16-year-old adolescents with physical disabilities was similar to 11-12-year-olds in the general population. Analysis of associations between disability status and health risk behaviors while controlling for age and sex showed that disability is associated with a lower likelihood of having tried smoking, smoking, having tasted an alcoholic drink, drinking, having been drunk, having used drugs, having used prescription drugs for recreational purposes, and eating sweets; a higher likelihood of not engaging in physical exercise, not eating fresh produce, and eating high-fat foods; and non-significant for seat-belt use. CONCLUSION: Health promotion programs about health risk behaviours designed for adolescents in the general population may not be appropriate for adolescents with physical disabilities.