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1.
Nature ; 626(8000): 785-791, 2024 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-38383628

RESUMEN

Mass loss of the Antarctic Ice Sheet has been driven primarily by the thinning of the floating ice shelves that fringe the ice sheet1, reducing their buttressing potential and causing land ice to accelerate into the ocean2. Observations of ice-shelf thickness change by satellite altimetry stretch back only to 1992 (refs. 1,3-5) and previous information about thinning remains unquantified. However, extending the record of ice-shelf thickness change is possible by proxy, by measuring the change in area of the surface expression of pinning points-local bathymetric highs on which ice shelves are anchored6. Here we measure pinning-point change over three epochs spanning the periods 1973-1989, 1989-2000 and 2000-2022, and thus by proxy infer changes to ice-shelf thickness back to 1973-1989. We show that only small localized pockets of ice shelves were thinning between 1973 and 1989, located primarily in the Amundsen Sea Embayment and the Wilkes Land coastline. Ice-shelf thinning spreads rapidly into the 1990s and 2000s and is best characterized by the proportion of pinning points reducing in extent. Only 15% of pinning points reduced from 1973 to 1989, before increasing to 25% from 1989 to 2000 and 37% from 2000 to 2022. A continuation of this trend would further reduce the buttressing potential of ice shelves, enhancing ice discharge and accelerating the contribution of Antarctica to sea-level rise.

2.
Proc Natl Acad Sci U S A ; 118(11)2021 Mar 16.
Artículo en Inglés | MEDLINE | ID: mdl-33729988

RESUMEN

Understanding magnetic-field generation and amplification in turbulent plasma is essential to account for observations of magnetic fields in the universe. A theoretical framework attributing the origin and sustainment of these fields to the so-called fluctuation dynamo was recently validated by experiments on laser facilities in low-magnetic-Prandtl-number plasmas ([Formula: see text]). However, the same framework proposes that the fluctuation dynamo should operate differently when [Formula: see text], the regime relevant to many astrophysical environments such as the intracluster medium of galaxy clusters. This paper reports an experiment that creates a laboratory [Formula: see text] plasma dynamo. We provide a time-resolved characterization of the plasma's evolution, measuring temperatures, densities, flow velocities, and magnetic fields, which allows us to explore various stages of the fluctuation dynamo's operation on seed magnetic fields generated by the action of the Biermann-battery mechanism during the initial drive-laser target interaction. The magnetic energy in structures with characteristic scales close to the driving scale of the stochastic motions is found to increase by almost three orders of magnitude and saturate dynamically. It is shown that the initial growth of these fields occurs at a much greater rate than the turnover rate of the driving-scale stochastic motions. Our results point to the possibility that plasma turbulence produced by strong shear can generate fields more efficiently at the driving scale than anticipated by idealized magnetohydrodynamics (MHD) simulations of the nonhelical fluctuation dynamo; this finding could help explain the large-scale fields inferred from observations of astrophysical systems.

3.
Proc Natl Acad Sci U S A ; 116(38): 18867-18873, 2019 09 17.
Artículo en Inglés | MEDLINE | ID: mdl-31481619

RESUMEN

Airborne radar sounding can measure conditions within and beneath polar ice sheets. In Antarctica, most digital radar-sounding data have been collected in the last 2 decades, limiting our ability to understand processes that govern longer-term ice-sheet behavior. Here, we demonstrate how analog radar data collected over 40 y ago in Antarctica can be combined with modern records to quantify multidecadal changes. Specifically, we digitize over 400,000 line kilometers of exploratory Antarctic radar data originally recorded on 35-mm optical film between 1971 and 1979. We leverage the increased geometric and radiometric resolution of our digitization process to show how these data can be used to identify and investigate hydrologic, geologic, and topographic features beneath and within the ice sheet. To highlight their scientific potential, we compare the digitized data with contemporary radar measurements to reveal that the remnant eastern ice shelf of Thwaites Glacier in West Antarctica had thinned between 10 and 33% between 1978 and 2009. We also release the collection of scanned radargrams in their entirety in a persistent public archive along with updated geolocation data for a subset of the data that reduces the mean positioning error from 5 to 2.5 km. Together, these data represent a unique and renewed extensive, multidecadal historical baseline, critical for observing and modeling ice-sheet change on societally relevant timescales.

4.
Circulation ; 142(16_suppl_1): S140-S184, 2020 10 20.
Artículo en Inglés | MEDLINE | ID: mdl-33084393

RESUMEN

This 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations (CoSTR) for pediatric life support is based on the most extensive evidence evaluation ever performed by the Pediatric Life Support Task Force. Three types of evidence evaluation were used in this review: systematic reviews, scoping reviews, and evidence updates. Per agreement with the evidence evaluation recommendations of the International Liaison Committee on Resuscitation, only systematic reviews could result in a new or revised treatment recommendation. Systematic reviews performed for this 2020 CoSTR for pediatric life support included the topics of sequencing of airway-breaths-compressions versus compressions-airway-breaths in the delivery of pediatric basic life support, the initial timing and dose intervals for epinephrine administration during resuscitation, and the targets for oxygen and carbon dioxide levels in pediatric patients after return of spontaneous circulation. The most controversial topics included the initial timing and dose intervals of epinephrine administration (new treatment recommendations were made) and the administration of fluid for infants and children with septic shock (this latter topic was evaluated by evidence update). All evidence reviews identified the paucity of pediatric data and the need for more research involving resuscitation of infants and children.


Asunto(s)
Reanimación Cardiopulmonar/normas , Enfermedades Cardiovasculares/terapia , Servicios Médicos de Urgencia/normas , Cuidados para Prolongación de la Vida/normas , Corticoesteroides/administración & dosificación , Arritmias Cardíacas/tratamiento farmacológico , Atropina/administración & dosificación , Reanimación Cardiopulmonar/métodos , Niño , Humanos , Choque Séptico/tratamiento farmacológico
5.
Notf Rett Med ; 24(4): 650-719, 2021.
Artículo en Alemán | MEDLINE | ID: mdl-34093080

RESUMEN

The European Resuscitation Council (ERC) Paediatric Life Support (PLS) guidelines are based on the 2020 International Consensus on Cardiopulmonary Resuscitation Science with Treatment Recommendations of the International Liaison Committee on Resuscitation (ILCOR). This section provides guidelines on the management of critically ill or injured infants, children and adolescents before, during and after respiratory/cardiac arrest.

6.
Circulation ; 140(24): e826-e880, 2019 12 10.
Artículo en Inglés | MEDLINE | ID: mdl-31722543

RESUMEN

The International Liaison Committee on Resuscitation has initiated a continuous review of new, peer-reviewed, published cardiopulmonary resuscitation science. This is the third annual summary of the International Liaison Committee on Resuscitation International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. It addresses the most recent published resuscitation evidence reviewed by International Liaison Committee on Resuscitation Task Force science experts. This summary addresses the role of cardiac arrest centers and dispatcher-assisted cardiopulmonary resuscitation, the role of extracorporeal cardiopulmonary resuscitation in adults and children, vasopressors in adults, advanced airway interventions in adults and children, targeted temperature management in children after cardiac arrest, initial oxygen concentration during resuscitation of newborns, and interventions for presyncope by first aid providers. Members from 6 International Liaison Committee on Resuscitation task forces have assessed, discussed, and debated the certainty of the evidence on the basis of the Grading of Recommendations, Assessment, Development, and Evaluation criteria, and their statements include consensus treatment recommendations. Insights into the deliberations of the task forces are provided in the Justification and Evidence to Decision Framework Highlights sections. The task forces also listed priority knowledge gaps for further research.


Asunto(s)
Reanimación Cardiopulmonar/normas , Servicios Médicos de Urgencia/normas , Tratamiento de Urgencia , Hipotermia Inducida/normas , Niño , Servicio de Urgencia en Hospital/normas , Tratamiento de Urgencia/normas , Humanos , Paro Cardíaco Extrahospitalario/terapia
7.
Circulation ; 138(23): e714-e730, 2018 12 04.
Artículo en Inglés | MEDLINE | ID: mdl-30571263

RESUMEN

The International Liaison Committee on Resuscitation has initiated a continuous review of new, peer-reviewed, published cardiopulmonary resuscitation science. This is the second annual summary of International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations that includes the most recent cardiopulmonary resuscitation science reviewed by the International Liaison Committee on Resuscitation. This summary addresses the role of antiarrhythmic drugs in adults and children and includes the Advanced Life Support Task Force and Pediatric Task Force consensus statements, which summarize the most recent published evidence and an assessment of the quality of the evidence based on Grading of Recommendations, Assessment, Development, and Evaluation criteria. The statements include consensus treatment recommendations approved by members of the relevant task forces. Insights into the deliberations of each task force are provided in the Values and Preferences and Task Force Insights sections. Finally, the task force members have listed the top knowledge gaps for further research.


Asunto(s)
Reanimación Cardiopulmonar , Paro Cardíaco Extrahospitalario/terapia , Amiodarona/uso terapéutico , Antiarrítmicos/uso terapéutico , Consenso , Servicios Médicos de Urgencia , Humanos , Lidocaína/uso terapéutico , Magnesio/uso terapéutico , Paro Cardíaco Extrahospitalario/tratamiento farmacológico
8.
Circulation ; 136(23): e424-e440, 2017 12 05.
Artículo en Inglés | MEDLINE | ID: mdl-29114010

RESUMEN

The International Liaison Committee on Resuscitation has initiated a near-continuous review of cardiopulmonary resuscitation science that replaces the previous 5-year cyclic batch-and-queue approach process. This is the first of an annual series of International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations summary articles that will include the cardiopulmonary resuscitation science reviewed by the International Liaison Committee on Resuscitation in the previous year. The review this year includes 5 basic life support and 1 pediatric Consensuses on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations. Each of these includes a summary of the science and its quality based on Grading of Recommendations, Assessment, Development, and Evaluation criteria and treatment recommendations. Insights into the deliberations of the International Liaison Committee on Resuscitation task force members are provided in Values and Preferences sections. Finally, the task force members have prioritized and listed the top 3 knowledge gaps for each population, intervention, comparator, and outcome question.


Asunto(s)
Cardiología/normas , Reanimación Cardiopulmonar/normas , Servicios Médicos de Urgencia/normas , Medicina de Emergencia/normas , Medicina Basada en la Evidencia/normas , Paro Cardíaco/terapia , Factores de Edad , Consenso , Paro Cardíaco/diagnóstico , Paro Cardíaco/mortalidad , Humanos , Paro Cardíaco Extrahospitalario/diagnóstico , Paro Cardíaco Extrahospitalario/mortalidad , Paro Cardíaco Extrahospitalario/terapia , Resultado del Tratamiento
9.
Nature ; 487(7408): 468-71, 2012 Jul 25.
Artículo en Inglés | MEDLINE | ID: mdl-22837002

RESUMEN

Current ice loss from the West Antarctic Ice Sheet (WAIS) accounts for about ten per cent of observed global sea-level rise. Losses are dominated by dynamic thinning, in which forcings by oceanic or atmospheric perturbations to the ice margin lead to an accelerated thinning of ice along the coastline. Although central to improving projections of future ice-sheet contributions to global sea-level rise, the incorporation of dynamic thinning into models has been restricted by lack of knowledge of basal topography and subglacial geology so that the rate and ultimate extent of potential WAIS retreat remains difficult to quantify. Here we report the discovery of a subglacial basin under Ferrigno Ice Stream up to 1.5 kilometres deep that connects the ice-sheet interior to the Bellingshausen Sea margin, and whose existence profoundly affects ice loss. We use a suite of ice-penetrating radar, magnetic and gravity measurements to propose a rift origin for the basin in association with the wider development of the West Antarctic rift system. The Ferrigno rift, overdeepened by glacial erosion, is a conduit which fed a major palaeo-ice stream on the adjacent continental shelf during glacial maxima. The palaeo-ice stream, in turn, eroded the 'Belgica' trough, which today routes warm open-ocean water back to the ice front to reinforce dynamic thinning. We show that dynamic thinning from both the Bellingshausen and Amundsen Sea region is being steered back to the ice-sheet interior along rift basins. We conclude that rift basins that cut across the WAIS margin can rapidly transmit coastally perturbed change inland, thereby promoting ice-sheet instability.

10.
Proc Natl Acad Sci U S A ; 112(27): 8211-5, 2015 Jul 07.
Artículo en Inglés | MEDLINE | ID: mdl-26100873

RESUMEN

The visible matter in the universe is turbulent and magnetized. Turbulence in galaxy clusters is produced by mergers and by jets of the central galaxies and believed responsible for the amplification of magnetic fields. We report on experiments looking at the collision of two laser-produced plasma clouds, mimicking, in the laboratory, a cluster merger event. By measuring the spectrum of the density fluctuations, we infer developed, Kolmogorov-like turbulence. From spectral line broadening, we estimate a level of turbulence consistent with turbulent heating balancing radiative cooling, as it likely does in galaxy clusters. We show that the magnetic field is amplified by turbulent motions, reaching a nonlinear regime that is a precursor to turbulent dynamo. Thus, our experiment provides a promising platform for understanding the structure of turbulence and the amplification of magnetic fields in the universe.


Asunto(s)
Fenómenos Astronómicos , Galaxias , Campos Magnéticos , Modelos Teóricos , Simulación por Computador , Rayos Láser , Sistema Solar , Análisis Espectral , Temperatura , Termodinámica
11.
Nat Commun ; 15(1): 6878, 2024 Aug 11.
Artículo en Inglés | MEDLINE | ID: mdl-39128934

RESUMEN

The non-linear optical process of laser harmonic generation (HG) enables the creation of high quality pulses of UV or even X-ray radiation, which have many potential uses at the frontiers of experimental science, ranging from lensless microscopy to ultrafast metrology and chiral science. Although many of the promising applications are enabled by generating harmonic modes with orbital angular momentum (OAM), independent control of the harmonic frequency and OAM level remains elusive. Here we show, through a theoretical approach, validated with 3D simulations, how unique 2-D harmonic progressions can be obtained, with both frequency and OAM level tuned independently, from tailored structured targets in both reflective and transmissive configurations. Through preferential selection of a subset of harmonic modes with a specific OAM value, a controlled frequency comb of circularly polarised harmonics can be produced. Our approach to describe HG, which simplifies both the theoretical predictions and the analysis of the harmonic spectrum, is directly applicable across the full range of HG mechanisms and can be readily applied to investigations of OAM harmonics in other processes, such as OAM cascades in Raman amplification, or the analysis of harmonic progressions in nonlinear optics.

12.
Nat Commun ; 14(1): 93, 2023 Jan 16.
Artículo en Inglés | MEDLINE | ID: mdl-36646677

RESUMEN

West Antarctica has experienced dramatic ice losses contributing to global sea-level rise in recent decades, particularly from Pine Island and Thwaites glaciers. Although these ice losses manifest an ongoing Marine Ice Sheet Instability, projections of their future rate are confounded by limited observations along West Antarctica's coastal perimeter with respect to how the pace of retreat can be modulated by variations in climate forcing. Here, we derive a comprehensive, 12-year record of glacier retreat around West Antarctica's Pacific-facing margin and compare this dataset to contemporaneous estimates of ice flow, mass loss, the state of the Southern Ocean and the atmosphere. Between 2003 and 2015, rates of glacier retreat and acceleration were extensive along the Bellingshausen Sea coastline, but slowed along the Amundsen Sea. We attribute this to an interdecadal suppression of westerly winds in the Amundsen Sea, which reduced warm water inflow to the Amundsen Sea Embayment. Our results provide direct observations that the pace, magnitude and extent of ice destabilization around West Antarctica vary by location, with the Amundsen Sea response most sensitive to interdecadal atmosphere-ocean variability. Thus, model projections accounting for regionally resolved ice-ocean-atmosphere interactions will be important for predicting accurately the short-term evolution of the Antarctic Ice Sheet.

13.
Nat Commun ; 13(1): 5526, 2022 09 21.
Artículo en Inglés | MEDLINE | ID: mdl-36130952

RESUMEN

The Antarctic continent reached its current polar location ~83 Ma and became shrouded by ice sheets ~34 Ma, coincident with dramatic global cooling at the Eocene-Oligocene boundary. However, it is not known whether the first Antarctic glaciers formed immediately prior to this or were present significantly earlier. Here we show that mountain glaciers were likely present in the Transantarctic Mountains during the Late Palaeocene (~60-56 Ma) and middle Eocene (~48-40 Ma). Temperate (warm-based) glaciers were prevalent during the Late Eocene (~40-34 Ma) and, in reduced numbers, during the Oligocene (~34-23 Ma), before larger, likely cold-based, ice masses (including ice sheets) dominated. Some temperate mountain glaciers were present during the Miocene Climatic Optimum (~15 Ma), before a widespread switch to cold-based glaciation. Our findings highlight the longevity of glaciation in Antarctica and suggest that glaciers were present even during the Early-Cenozoic greenhouse world.


Asunto(s)
Cubierta de Hielo , Regiones Antárticas
14.
Sci Adv ; 8(10): eabj6799, 2022 Mar 11.
Artículo en Inglés | MEDLINE | ID: mdl-35263132

RESUMEN

In conventional gases and plasmas, it is known that heat fluxes are proportional to temperature gradients, with collisions between particles mediating energy flow from hotter to colder regions and the coefficient of thermal conduction given by Spitzer's theory. However, this theory breaks down in magnetized, turbulent, weakly collisional plasmas, although modifications are difficult to predict from first principles due to the complex, multiscale nature of the problem. Understanding heat transport is important in astrophysical plasmas such as those in galaxy clusters, where observed temperature profiles are explicable only in the presence of a strong suppression of heat conduction compared to Spitzer's theory. To address this problem, we have created a replica of such a system in a laser laboratory experiment. Our data show a reduction of heat transport by two orders of magnitude or more, leading to large temperature variations on small spatial scales (as is seen in cluster plasmas).

15.
Paediatr Anaesth ; 21(1): 72-7, 2011 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-21073626

RESUMEN

OBJECTIVES: To perform a retrospective, anesthesia case note review in children with Apert Syndrome. AIM: To identify perioperative complications in this group of patients. BACKGROUND: Apert syndrome is a rare autosomal dominant disorder characterized by craniosynostosis, craniofacial anomalies, and severe symmetrical syndactyly (cutaneous and bony fusion) of the hands and feet. Children with this syndrome require general anesthetics for a number of different operations and procedures. Our institution has records of 71 children with Apert syndrome. Analysis of their general anesthetic records was undertaken, and the incidence of perioperative complications was investigated. METHODS: A retrospective case note review was performed on 61 children with Apert syndrome over a 14-year period. There were a total of 509 general anesthetics administered to these children during this period of time. RESULTS: There were a total of 31 perioperative respiratory complications occurring in 21 patients (6.1% of the total cases). Twenty-three of these complications were supraglottic airway obstruction (4.5% of total cases). CONCLUSIONS: We found there to be a low incidence of major perioperative major complications in this group of patients. Nevertheless, a significant proportion of these children have obstructive sleep apnoea and may develop supraglottic airway obstruction on induction and emergence from anesthesia due to the associated mid-face anatomical abnormalities.


Asunto(s)
Acrocefalosindactilia/cirugía , Anestesia , Periodo Perioperatorio , Acrocefalosindactilia/diagnóstico , Acrocefalosindactilia/genética , Adyuvantes Anestésicos , Adolescente , Anestesia General , Anestesia por Inhalación , Atropina , Niño , Preescolar , Presión de las Vías Aéreas Positiva Contínua , Anomalías Craneofaciales/cirugía , Femenino , Humanos , Lactante , Recién Nacido , Masculino , Procedimientos Ortopédicos , Atención Perioperativa , Procedimientos de Cirugía Plástica , Pruebas de Función Respiratoria , Estudios Retrospectivos , Apnea Obstructiva del Sueño/complicaciones
16.
Curr Opin Anaesthesiol ; 24(3): 282-8, 2011 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-21478740

RESUMEN

PURPOSE OF REVIEW: The aim of this review is to outline the priorities in the anaesthetic management of the child with facial abnormalities. It presents a practical approach to this, based on the anatomical site of the deformity and degree of mouth opening. RECENT FINDINGS: The literature reviewed primarily consists of case reports and series describing anaesthesia in children with relevant syndromes. Also scrutinized is the literature examining the role and effectiveness of recently developed airway management equipment. SUMMARY: This is a challenging area of anaesthetic practice but the use of a structured approach, combined with supraglottic airway devices and fibre-optic and indirect laryngoscopic equipment, has allowed the safe administration of anaesthesia to almost all children with conditions resulting in facial abnormality.


Asunto(s)
Manejo de la Vía Aérea , Cara/anomalías , Anestesia , Niño , Presión de las Vías Aéreas Positiva Contínua , Tecnología de Fibra Óptica , Glotis/patología , Humanos , Intubación Intratraqueal/métodos , Máscaras Laríngeas , Laringoscopios , Laringoscopía , Mandíbula/anomalías , Maxilar/anomalías , Relajantes Musculares Centrales/uso terapéutico , Respiración Artificial , Anomalías del Sistema Respiratorio/complicaciones , Anomalías del Sistema Respiratorio/terapia
17.
Resuscitation ; 161: 327-387, 2021 04.
Artículo en Inglés | MEDLINE | ID: mdl-33773830

RESUMEN

These European Resuscitation Council Paediatric Life Support (PLS) guidelines, are based on the 2020 International Consensus on Cardiopulmonary Resuscitation Science with Treatment Recommendations. This section provides guidelines on the management of critically ill infants and children, before, during and after cardiac arrest.


Asunto(s)
Reanimación Cardiopulmonar , Paro Cardíaco , Niño , Cardioversión Eléctrica , Paro Cardíaco/terapia , Humanos , Lactante
18.
Resuscitation ; 160: 106-117, 2021 03.
Artículo en Inglés | MEDLINE | ID: mdl-33529645

RESUMEN

AIM: To evaluate the optimal timing and doses of epinephrine for Infants and children suffering in-hospital or out-of-hospital cardiac arrest. METHODS: We searched Medline, EMBASE, and Cochrane Controlled Register of Trials (CENTRAL) for human randomized clinical trials and observational studies including comparative cohorts. Two investigators reviewed relevance of studies, extracted the data, conducted meta-analyses and assessed the risk of bias using the GRADE and CLARITY frameworks. Authors of the eligible studies were contacted to obtain additional data. Critically important outcomes included return of spontaneous circulation, survival to hospital discharge and survival with good neurological outcome. RESULTS: We identified 7 observational studies suitable for meta-analysis and no randomized clinical trials. The overall certainty of evidence was very low. For the critically important outcomes, the earlier administration of epinephrine was favorable for both in-hospital and out-of-hospital cardiac arrest. Because of a limited number of eligible studies and the presence of severe confounding factors, we could not determine the optimal interval of epinephrine administration. CONCLUSIONS: Earlier administration of the first epinephrine dose could be more favorable in non-shockable pediatric cardiac arrest. The optimal interval for epinephrine administration remains unclear.


Asunto(s)
Epinefrina , Paro Cardíaco Extrahospitalario , Niño , Humanos , Lactante , Paro Cardíaco Extrahospitalario/tratamiento farmacológico , Alta del Paciente
19.
Pediatrics ; 147(Suppl 1)2021 01.
Artículo en Inglés | MEDLINE | ID: mdl-33087557

RESUMEN

This 2020 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations (CoSTR) for pediatric life support is based on the most extensive evidence evaluation ever performed by the Pediatric Life Support Task Force. Three types of evidence evaluation were used in this review: systematic reviews, scoping reviews, and evidence updates. Per agreement with the evidence evaluation recommendations of the International Liaison Committee on Resuscitation, only systematic reviews could result in a new or revised treatment recommendation.Systematic reviews performed for this 2020 CoSTR for pediatric life support included the topics of sequencing of airway-breaths-compressions versus compressions-airway-breaths in the delivery of pediatric basic life support, the initial timing and dose intervals for epinephrine administration during resuscitation, and the targets for oxygen and carbon dioxide levels in pediatric patients after return of spontaneous circulation. The most controversial topics included the initial timing and dose intervals of epinephrine administration (new treatment recommendations were made) and the administration of fluid for infants and children with septic shock (this latter topic was evaluated by evidence update). All evidence reviews identified the paucity of pediatric data and the need for more research involving resuscitation of infants and children.


Asunto(s)
Reanimación Cardiopulmonar/normas , Consenso , Servicios Médicos de Urgencia/normas , Servicio de Urgencia en Hospital/normas , Paro Cardíaco Extrahospitalario/terapia , American Heart Association , Humanos , Estados Unidos
20.
Resuscitation ; 156: 174-181, 2020 11.
Artículo en Inglés | MEDLINE | ID: mdl-32949674

RESUMEN

OBJECTIVE: To summarise in a systematic review the effectiveness of interventions to treat foreign body airway obstructions (FBAO). METHODS: We searched MEDLINE, EMBASE, and the Cochrane library from inception on 30th September 2019 for studies that described the effectiveness of interventions to treat FBAO in adults and children. We included randomised controlled trials, observational studies and case series (≥5 cases) that described evidence of benefit. For evidence of harm/complications, we included case reports. Two reviewers independently assessed study eligibility, extracted study data, and assessed risk of bias. Data are summarised in a narrative synthesis. The GRADE system is used to assess evidence certainty. RESULTS: We included 69 publications, comprising three cross-sectional studies (557 patients); eight case series (755 patients), and 59 were case reports (64 patients). One paper was included as a case series and cross-sectional study. For all interventions and associated outcomes, evidence certainty was very low. Early removal of FBAO by bystanders was associated with improved neurological survival (odds ratio 6.0, 95% confidence interval 1.5 to 23.4). Identified evidence showed that key interventions (back blows, abdominal thrusts, chest thrusts/compressions, Magill forceps, manual removal of obstructions from the mouth, suction-based airway clearance devices) are effective in relieving FBAO. We identified reports of harm in relation to back blows, abdominal thrusts, chest thrusts/compressions, and blind finger sweeps. CONCLUSIONS: Key interventions successfully relieve FBAO, but may be associated with important harms. Guidelines for FBAO management should balance the benefits and harms of interventions.


Asunto(s)
Obstrucción de las Vías Aéreas , Cuerpos Extraños , Adulto , Obstrucción de las Vías Aéreas/etiología , Obstrucción de las Vías Aéreas/terapia , Sesgo , Niño , Estudios Transversales , Cuerpos Extraños/complicaciones , Cuerpos Extraños/terapia , Humanos
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