RESUMEN
PURPOSE: Aspirin is effective in secondary prevention of cardiovascular disease. The results are less convincing when aspirin is used for primary prevention even in high-risk patients (i.e., patients with diabetes). We therefore analyzed the effect of aspirin on mortality and serious bleeding in diabetic patients with and without cardiovascular disease. METHODS: We performed a record linkage study of the patient registry of the Västra Götaland region in south-western Sweden, the Swedish mortality register and the Swedish register of dispensed drugs. All diabetic patients (n = 58 465) from 1 July 2005 to 30 June 2006 were followed up with respect to bleeding until 31 October 2006, and mortality until 31 December 2006. RESULTS: When 19 confounding factors (diseases and interventions) were assessed, aspirin significantly increased mortality in diabetic patients without cardiovascular disease from 17% (95% confidence interval; 95%CI, 1-36) at age 50 years to 29% (16-43) at age 85 years. In contrast aspirin tended to decrease mortality among elderly diabetic patients with cardiovascular disease. Theoretical calculations indicated that aspirin caused 107 excess deaths among diabetic patients without cardiovascular disease and prevented 164 deaths among diabetic patients with cardiovascular disease. Aspirin also increased the risk of serious bleeding by 46% (95%CI, 22-75) in diabetic patients without cardiovascular disease but decreased the risk among those with cardiovascular disease. CONCLUSION: Aspirin use in diabetes patients without cardiovascular disease remains controversial and current guidelines should be revised until results from ongoing large randomized controlled trials become available.
Asunto(s)
Aspirina/efectos adversos , Enfermedades Cardiovasculares/mortalidad , Complicaciones de la Diabetes/mortalidad , Hemorragia Gastrointestinal/inducido químicamente , Registro Médico Coordinado , Inhibidores de Agregación Plaquetaria/efectos adversos , Factores de Edad , Anciano , Aspirina/administración & dosificación , Aspirina/uso terapéutico , Enfermedades Cardiovasculares/prevención & control , Complicaciones de la Diabetes/prevención & control , Femenino , Humanos , Masculino , Persona de Mediana Edad , Inhibidores de Agregación Plaquetaria/administración & dosificación , Inhibidores de Agregación Plaquetaria/uso terapéutico , Prevención Secundaria , SueciaAsunto(s)
Antipsicóticos , Esquizofrenia/mortalidad , Adulto , Antipsicóticos/efectos adversos , Antipsicóticos/economía , Antipsicóticos/uso terapéutico , Aripiprazol , Comorbilidad , Costos de los Medicamentos/estadística & datos numéricos , Quimioterapia/economía , Quimioterapia/mortalidad , Quimioterapia/estadística & datos numéricos , Efectos Colaterales y Reacciones Adversas Relacionados con Medicamentos , Humanos , Seguro por Discapacidad/economía , Seguro por Discapacidad/estadística & datos numéricos , Persona de Mediana Edad , Piperazinas/efectos adversos , Piperazinas/economía , Piperazinas/uso terapéutico , Quinolonas/efectos adversos , Quinolonas/economía , Quinolonas/uso terapéutico , Esquizofrenia/tratamiento farmacológico , Esquizofrenia/economía , Ausencia por Enfermedad/estadística & datos numéricos , SueciaRESUMEN
BACKGROUND: Drug costs are increasing despite the introduction of cheaper generic drugs. The aim of the present study was to analyse the entire costs of hospital care, out-patient care, and the cost of drugs for 16 months following a myocardial infarction (MI) to see to what extent drug costs contribute to the overall costs of care. METHODS: Diagnoses and costs for care as well as mortality data obtained from the Västra Götaland Region, Sweden, and drug costs from the Swedish Board of Health and Welfare, were merged in a computer file. Patients registered from 1 July 2005 to 30 June 2006 were followed from 28 days after an MI, with follow-up until 31 October 2006. RESULTS: Of 4,725 patients, 711 died before the start of the study and 721 during follow-up. Higher age [hazard ratio (HR, 95%CI) = 1.06 (1.05-1.07)], previous MI [HR = 1.31 (1.13-1.53)] and diabetes mellitus [HR = 1.34 (1.13-1.58)] were associated with increased mortality, which decreased with coronary interventions: CABG/PCI [HR = 0.19 (0.14-0.27)]. In a multivariable analysis, mortality was lower for patients taking simvastatin [HR = 0.62 (0.50-0.76)] and clopidogrel [HR = 0.58 (0.46-0.74)]. CONCLUSION: Costs for out-patient care accounted for 25% and drugs for 5% of total costs. If patients not treated with simvastatin or clopidogrel had received these drugs, an additional 154-306 lives might have been saved. Drug costs would be higher, but total costs lower. Thus, even expensive drugs may reduce overall costs.