1.
Proc Natl Acad Sci U S A
; 101(33): 12019-23, 2004 Aug 17.
Artículo
en Inglés
| MEDLINE
| ID: mdl-15273284
RESUMEN
The total synthesis of the molluscan polypropionate (-)-crispatene is described. The synthesis features a palladium-catalyzed cross-coupling to establish a sensitive conjugated tetraene and its Lewis acid-catalyzed cycloisomerization to yield the bicyclo[3.1.0]hexene core of the natural product. The absolute configuration of (-)-crispatene and related molecules is established.