Búsqueda | BVS CLAP/SMR-OPS/OMS

1.

Tuning Hsp104 specificity to selectively detoxify α-synuclein.

Mack, Korrie L; Kim, Hanna; Barbieri, Edward M; Lin, JiaBei; Braganza, Sylvanne; Jackrel, Meredith E; DeNizio, Jamie E; Yan, Xiaohui; Chuang, Edward; Tariq, Amber; Cupo, Ryan R; Castellano, Laura M; Caldwell, Kim A; Caldwell, Guy A; Shorter, James.

Mol Cell ; 83(18): 3314-3332.e9, 2023 09 21.

Artículo en Inglés | MEDLINE | ID: mdl-37625404

2.

Potentiated Hsp104 variants antagonize diverse proteotoxic misfolding events.

Jackrel, Meredith E; DeSantis, Morgan E; Martinez, Bryan A; Castellano, Laura M; Stewart, Rachel M; Caldwell, Kim A; Caldwell, Guy A; Shorter, James.

Cell ; 156(1-2): 170-82, 2014 Jan 16.

Artículo en Inglés | MEDLINE | ID: mdl-24439375

3.

Integrated regulation of dopaminergic and epigenetic effectors of neuroprotection in Parkinson's disease models.

Nourse, J Brucker; Russell, Shannon N; Moniz, Nathan A; Peter, Kylie; Seyfarth, Lena M; Scott, Madison; Park, Han-A; Caldwell, Kim A; Caldwell, Guy A.

Proc Natl Acad Sci U S A ; 120(7): e2210712120, 2023 02 14.

Artículo en Inglés | MEDLINE | ID: mdl-36745808

4.

Systemic RNA Interference Defective (SID) genes modulate dopaminergic neurodegeneration in C. elegans.

Gaeta, Anthony L; Nourse, J Brucker; Willicott, Karolina; McKay, Luke E; Keogh, Candice M; Peter, Kylie; Russell, Shannon N; Hamamichi, Shusei; Berkowitz, Laura A; Caldwell, Kim A; Caldwell, Guy A.

PLoS Genet ; 18(8): e1010115, 2022 08.

Artículo en Inglés | MEDLINE | ID: mdl-35984862

5.

From bugs to bedside: functional annotation of human genetic variation for neurological disorders using invertebrate models.

Mew, Melanie; Caldwell, Kim A; Caldwell, Guy A.

Hum Mol Genet ; 31(R1): R37-R46, 2022 10 20.

Artículo en Inglés | MEDLINE | ID: mdl-35994032

6.

A conformational switch driven by phosphorylation regulates the activity of the evolutionarily conserved SNARE Ykt6.

McGrath, Kaitlyn; Agarwal, Shivani; Tonelli, Marco; Dergai, Mykola; Gaeta, Anthony L; Shum, Andrew K; Lacoste, Jessica; Zhang, Yongbo; Wen, Wenyu; Chung, Daayun; Wiersum, Grant; Shevade, Aishwarya; Zaichick, Sofia; van Rossum, Damian B; Shuvalova, Ludmilla; Savas, Jeffrey N; Kuchin, Sergei; Taipale, Mikko; Caldwell, Kim A; Caldwell, Guy A; Fasshauer, Dirk; Caraveo, Gabriela.

Proc Natl Acad Sci U S A ; 118(12)2021 03 23.

Artículo en Inglés | MEDLINE | ID: mdl-33723042

7.

Barriers to palliative care in hepatocellular carcinoma: A review of the literature.

Abasseri, Mostafa; Hoque, Shakira; Slavica Kochovska, B A; Caldwell, Kim; Sheahan, Linda; Zekry, Amany.

J Gastroenterol Hepatol ; 38(7): 1047-1055, 2023 Jul.

Artículo en Inglés | MEDLINE | ID: mdl-36634200

8.

Distinct functional roles of Vps41-mediated neuroprotection in Alzheimer's and Parkinson's disease models of neurodegeneration.

Griffin, Edward F; Yan, Xiaohui; Caldwell, Kim A; Caldwell, Guy A.

Hum Mol Genet ; 27(24): 4176-4193, 2018 12 15.

Artículo en Inglés | MEDLINE | ID: mdl-30508205

9.

Alpha-synuclein inhibits Snx3-retromer-mediated retrograde recycling of iron transporters in S. cerevisiae and C. elegans models of Parkinson's disease.

Patel, Dhaval; Xu, Chuan; Nagarajan, Sureshbabu; Liu, Zhengchang; Hemphill, Wayne O; Shi, Runhua; Uversky, Vladimir N; Caldwell, Guy A; Caldwell, Kim A; Witt, Stephan N.

Hum Mol Genet ; 27(9): 1514-1532, 2018 05 01.

Artículo en Inglés | MEDLINE | ID: mdl-29452354

10.

NCEH-1 modulates cholesterol metabolism and protects against α-synuclein toxicity in a C. elegans model of Parkinson's disease.

Zhang, Siyuan; Glukhova, Samantha A; Caldwell, Kim A; Caldwell, Guy A.

Hum Mol Genet ; 26(19): 3823-3836, 2017 10 01.

Artículo en Inglés | MEDLINE | ID: mdl-28934392

11.

Genetic Defects in Mitochondrial Dynamics in Caenorhabditis elegans Impact Ultraviolet C Radiation- and 6-hydroxydopamine-Induced Neurodegeneration.

Hartman, Jessica H; Gonzalez-Hunt, Claudia; Hall, Samantha M; Ryde, Ian T; Caldwell, Kim A; Caldwell, Guy A; Meyer, Joel N.

Int J Mol Sci ; 20(13)2019 Jun 29.

Artículo en Inglés | MEDLINE | ID: mdl-31261893

12.

Dysregulation of the Mitochondrial Unfolded Protein Response Induces Non-Apoptotic Dopaminergic Neurodegeneration in C. elegans Models of Parkinson's Disease.

Martinez, Bryan A; Petersen, Daniel A; Gaeta, Anthony L; Stanley, Samuel P; Caldwell, Guy A; Caldwell, Kim A.

J Neurosci ; 37(46): 11085-11100, 2017 11 15.

Artículo en Inglés | MEDLINE | ID: mdl-29030433

13.

Clioquinol promotes the degradation of metal-dependent amyloid-ß (Aß) oligomers to restore endocytosis and ameliorate Aß toxicity.

Matlack, Kent E S; Tardiff, Daniel F; Narayan, Priyanka; Hamamichi, Shusei; Caldwell, Kim A; Caldwell, Guy A; Lindquist, Susan.

Proc Natl Acad Sci U S A ; 111(11): 4013-8, 2014 Mar 18.

Artículo en Inglés | MEDLINE | ID: mdl-24591589

14.

Phosphatidylethanolamine deficiency disrupts α-synuclein homeostasis in yeast and worm models of Parkinson disease.

Wang, Shaoxiao; Zhang, Siyuan; Liou, Liang-Chun; Ren, Qun; Zhang, Zhaojie; Caldwell, Guy A; Caldwell, Kim A; Witt, Stephan N.

Proc Natl Acad Sci U S A ; 111(38): E3976-85, 2014 Sep 23.

Artículo en Inglés | MEDLINE | ID: mdl-25201965

15.

Calcineurin determines toxic versus beneficial responses to α-synuclein.

Caraveo, Gabriela; Auluck, Pavan K; Whitesell, Luke; Chung, Chee Yeun; Baru, Valeriya; Mosharov, Eugene V; Yan, Xiaohui; Ben-Johny, Manu; Soste, Martin; Picotti, Paola; Kim, Hanna; Caldwell, Kim A; Caldwell, Guy A; Sulzer, David; Yue, David T; Lindquist, Susan.

Proc Natl Acad Sci U S A ; 111(34): E3544-52, 2014 Aug 26.

Artículo en Inglés | MEDLINE | ID: mdl-25122673

16.

RTCB-1 mediates neuroprotection via XBP-1 mRNA splicing in the unfolded protein response pathway.

Ray, Arpita; Zhang, Siyuan; Rentas, Courtney; Caldwell, Kim A; Caldwell, Guy A.

J Neurosci ; 34(48): 16076-85, 2014 Nov 26.

Artículo en Inglés | MEDLINE | ID: mdl-25429148

17.

Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity.

Usenovic, Marija; Knight, Adam L; Ray, Arpita; Wong, Victoria; Brown, Kevin R; Caldwell, Guy A; Caldwell, Kim A; Stagljar, Igor; Krainc, Dimitri.

Hum Mol Genet ; 21(17): 3785-94, 2012 Sep 01.

Artículo en Inglés | MEDLINE | ID: mdl-22645275

18.

Life lessons.

Caldwell, Kim.

Palliat Support Care ; 17(3): 367-368, 2019 06.

Artículo en Inglés | MEDLINE | ID: mdl-30033905

19.

Functional analysis of VPS41-mediated neuroprotection in Caenorhabditis elegans and mammalian models of Parkinson's disease.

Harrington, Adam J; Yacoubian, Talene A; Slone, Sunny R; Caldwell, Kim A; Caldwell, Guy A.

J Neurosci ; 32(6): 2142-53, 2012 Feb 08.

Artículo en Inglés | MEDLINE | ID: mdl-22323726

20.

Different 8-hydroxyquinolines protect models of TDP-43 protein, α-synuclein, and polyglutamine proteotoxicity through distinct mechanisms.

Tardiff, Daniel F; Tucci, Michelle L; Caldwell, Kim A; Caldwell, Guy A; Lindquist, Susan.

J Biol Chem ; 287(6): 4107-20, 2012 Feb 03.

Artículo en Inglés | MEDLINE | ID: mdl-22147697

BVS CLAP/SMR-OPS/OMS

Centro Latinoamericano de Perinatología, Salud de la Mujer y Reproductiva

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