1.
Bioorg Med Chem Lett
; 22(5): 1944-8, 2012 Mar 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-22321214
RESUMEN
A series of 1,6-naphthyridine-based compounds was synthesized as potent phosphodiesterase 10A (PDE10A) inhibitors. Structure-based chemical modifications of the discovered chemotype served to further improve potency and selectivity over DHODH, laying the foundation for future optimization efforts.