A longitudinal study on changes in weekend leisure time by age groups in Korea (1999-2019).

BACKGROUND: Data analysis was conducted on 20 years (1999-2019) of the Korean Time Use Survey (KTUS) to identify differences and characteristics among each types by extracting latent clusters of weekend leisure activities. METHODS: Using data from the KTUS, we classified weekend leisure time activities into 6 distinct categories. To identify the latent clusters for each year's KTUS data, we utilized latent profile analysis (LPA). Furthermore, independent samples t-tests and one-way ANOVA were conducted to investigate the characteristics of each latent cluster. RESULTS: As a result of leisure time analysis by survey period, media use accounted for the largest share in all three age groups. The results of the LPA, which included media, sports, culture, and tourism, revealed that the distribution of leisure time for these activities was lower throughout the entire study period. CONCLUSION: Based on the results of this study, it is recommended to explore constructive leisure activities and to develop policy measures to promote the domestic leisure industry and leisure consumption.

Analysis of Differences in the Degree of Biomechanical Adaptation according to Habituation to Different Heel Heights.

This study aims to comprehensively investigate whether there are any differences in the degree of biomechanical adaptation according to habituation to different heel heights. The biomechanical characteristics of 54 subjects in 3 groups habituated to three heel heights (low, medium-high, and high heels) were evaluated by the measurement of surface EMG, myotonometer (e.g., measurement of muscle tension), foot pressure, and lumbosacral angle, and comparative analysis was carried out to find out whether they showed differences in the comfort visual analog scale (comfort VAS). Wearers of high-heeled shoes (6 cm or more in heel height), in foot pressure comparison, showed significantly high peak pressure in the mask of the hallux, high maximum peak EMG in the gastrocnemius medius (GM), and a high percentage of maximum voluntary isometric contraction (%MVIC) in the plantar flexor. Wearers of low-heeled shoes (3 cm and below in heel height) showed the highest plantar peak pressure in the lateral forefoot and midfoot, the highest contact area in midfoot, the highest %MVIC in the plantar flexion and dorsiflexion of the tibialis anterior (TA), and the highest stiffness in the TA, and they showed the lowest static balance ability with eyes open (EO) among the three groups. It was found that there were significant differences between those habituated to high-heeled shoes and those not habituated to high-heeled shoes and that longtime wearing of high-heeled shoes brings about biomechanical adaptive changes in the human body.

Effects of mental practice with action observation training on occupational performance after stroke.

BACKGROUND: Studies on whether mental practice (MP) in patients with stroke using action observation training (AOT) is effective in improving physical performance are still insufficient. To examine the effects of MP on both occupational performance and motor function to complement studies relevant to MP with AOT. METHODS: Subjects of this study were 3 individuals who were diagnosed with stroke. We used an A-B-A study design with follow-up evaluation, which is a type of reversal single experimental research design. A total of 20 experimental sessions were conducted. To assess the long-term effect of MP with AOT, follow-up baseline measurements were made after 2 weeks without MP. Three-dimensional motion analysis and electromyography were conducted during each of the 20 sessions. The Motor Activity Log and Assessment of Motor and Process Skills were measured 3 times: in the pre-MP phase, the post-MP phase, and the 2-week follow-up phase. RESULTS: Occupational performance improved after intervention in all 3 subjects when applying an MP task using AOT. All subjects showed improvement of motor functions, including smoothness of movement, agonistic muscle activation, and co-ordination. The treatment effect continued after 2 weeks. CONCLUSIONS: MP using AOT in patients with stroke is an effective treatment protocol to improve occupational performance and motor function. Thus, MP using AOT may be applicable for treating stroke patients with stroke not only while they are in the hospital but also at home or in the community.

5'-Triphosphate-RNA-independent activation of RIG-I via RNA aptamer with enhanced antiviral activity.

RIG-I is a cytosolic receptor for non-self RNA that mediates immune responses against viral infections through IFNα/ß production. In an attempt to identify novel tools that modulate IFNα/ß production, we used SELEX technology to screen RNA aptamers that specifically target RIG-I protein. Most of the selected RIG-I aptamers contained polyU motifs in the second half regions that played critical roles in the activation of RIG-I-mediated IFNß production. Unlike other known ligands, RIG-I aptamer bound and activated RIG-I in a 5'-triphosphate-independent manner. The helicase and RD domain of RIG-I were used for aptamer binding, but intact RIG-I protein was required to exert aptamer-mediated signaling activation. Furthermore, replication of NDV, VSV and influenza virus in infected host cells was efficiently blocked by pre- or post-treatment with RIG-I aptamer. Based on these data, we propose that RIG-I aptamer has strong potential to be an antiviral agent that specifically boosts the RIG-I-dependent signaling cascade.

Life satisfaction analysis between occupational balance (OB) group and occupational imbalance (OI) group.

BACKGROUND AND OBJECTIVES: Occupation and time-use can never be separated because they are important criteria in determining one's lifestyle, improvements of one's lifestyle, and even the quality of life. The purpose of this study was to identify whether there is a difference in time-use between the occupational balance (OB) group and occupational imbalance (OI) group and to determine the factors that influence the life satisfaction of those in the OB group. METHODS: This study sorted detailed activities of 9,228 participants who were over 65 years of age. Raw data of 2014 Korean Time Use Survey (KTUS) were used and the amount of time-use of older adults was classified into eight activity areas. This study classified the amount of time used by older adults for eight occupational areas, namely, activities of daily life (ADLs), instrumental ADL (IADLs), rest and sleep, education, work, play, leisure, and social participation. We identified areas of specific time differences between OB and OI groups, and confirmed variables affecting life satisfaction. RESULTS: The analysis of time-use corresponding to the eight occupational areas showed the greatest time-use for the instrumental activities of daily living, which averaged 1513.59 minutes (56.34%). The largest effect size was social participation (d = 1.38). As a result of analyzing the factors related to the life satisfaction of the OB group, we found that those who were younger (B = 0.02, p < .001), females (B = -0.12, p < .05), had a higher level of education (B = 0.65, p < .001), had a lower need for care (B = -1.19, p < .05), had a higher income (B = -0.43, p < .001), and rural residence (B = 0.29, p < .001) tended to have a higher life satisfaction. CONCLUSIONS: This study may provide a basis for developing time-use management and lifestyle redesign programs.

Effectiveness of Shock-Absorbing Insole for High-Heeled Shoes on Gait: Randomized Controlled Trials.

This study was carried out to identify the influence of a shock-absorbing insole, developed by the author for use with high-heeled shoes, on walking. The research design included single-blind randomized parallel groups; namely, a group of 26 participants who wore the shock-absorbing insoles and another group of 26 participants who did not wear the insoles, both carried out walking while wearing 7 cm high-heels. During walking, plantar pressure analysis (via in-shoe plantar pressure measurements), surface electrode electromyography (surface EMG), gait analysis, subjective comfort evaluation, and functional movement (functional mobility) analysis were carried out. In order to compare the two groups, statistical verification (paired t-test) was performed. Wearing the shock-absorbing insole with the high-heeled shoes improved posture stability during walking, as well as increasing the walking speed. In addition, the heel pressure, the pressure of the front foot at the inner side, and the shock ability were decreased. For these reasons, the wearers reported higher comfort. Changes in the muscle activities of the tibialis anterior muscle (TA) and the gastrocnemius muscle (GA) heightened the stability of the ankle joints. Overall, the proposed shock-absorbing insole for use with high-heeled shoes improved the postural stability when walking, as well as improving the distribution of pressure on the soles. A decrease in the diverse side-effects of wearing high-heeled shoes can thus be expected.

Effects of environmental modification on activities of daily living, social participation and quality of life in the older adults: a meta-analysis of randomized controlled trials.

Purpose: This study aims to provide evidence of the benefits and effects of environmental modification intervention on activities of daily living, quality of life and social participation in older adults.Methods: This study searched and used randomized controlled trial research studies from the databases of MEDLINE, CINAHL and the Cochrane Library. A systematic review and meta-analysis were conducted using the Jadad scale, risk of bias and the patient, intervention, comparison, outcome (PICO) process. The domains of impact considered in this meta-analysis were activities of daily living, quality of life and social participation. The analysis was completed with the Review Manager software 5.3.Results: Jadad scores of collected studies were 3-4 in seven studies and 2 in one study, which means that most studies had high levels of quality. This study comprised of 733 subjects in the experimental group and 672 subjects in the control group. The effect size of environmental interventions on basic activities of daily living, instrumental activities of daily living and overall activities of daily living were 0.37, 0.65 and 0.47, respectively. Meanwhile, the environmental intervention was neither effective on quality of life nor social participation.Conclusions: Environmental modifications are effective in facilitating the daily life activities of older adults. This kind of intervention is shown to be useful for enhancing life performance. In order to confirm intervention effects on the quality of life and social participation of older adults, studies should conduct environmental modifications interventions that take into account contexts such as individual characteristics, lifestyle and physical activities.Implications for rehabilitationEnvironmental modifications are effective in improving older adults' performance of daily activities (ADL).Appropriate environmental modification interventions should be considered before the quality of life (QoL) and levels of social participation of older adults decline.

The Economic Burden of Stroke Based on South Korea's National Health Insurance Claims Database.

BACKGROUND: This study was conducted to determine the scale and the nature of the economic burden caused by strokes and to use the results as an evidential source for determining the allocation of South Korea stroke cases in 2015. METHODS: For research subjects, the study analyzed demographic characteristics and economic burden based on data from national health insurance (NHI) claims for inpatient and outpatient cases of ischemic stroke and hemorrhagic stroke in 2015 through the Health Insurance Review and Assessment Service (HIRA) and statistical data regarding cause of death from the Korea National Statistical Office (KNSO). This study, in order to estimate economic burden due to stroke, deduced the direct and indirect costs of illness caused by stroke, using cost-of-illness (COI) methods. The economic burden is divided into direct and indirect costs, and indirect cost is estimated by summing lost productivity measured in opportunity cost lost by medical disposition due to a specific disease and lost productivity due to premature death. RESULTS: The total economic burden in Korea due to stroke was US$6.855 billion, that due to ischemic stroke was US$3.658 billion, and that due to hemorrhagic stroke was US$3.197 billion. The average economic burden per stroke case was about US$7247. CONCLUSION: The results of estimating the annual economic burden in all of Korea due to stroke will be used as an evidential source for preparing medical insurance policies, priorities, and plans for arranging medical resources for stroke as well as for determining effective prevention of the disease and related priorities in national health care policies.

Correlation between Leisure Activity Time and Life Satisfaction: Based on KOSTAT Time Use Survey Data.

RATIONALE: This study aims to investigate the correlation between the available leisure activity time and life satisfaction of the healthy elderly and the factors affecting them. METHOD: For the analysis, data from the 2014 Time Use Survey (2014TUS) published by Statistics Korea (KOSTAT) was used. This study classified the detailed activities of 9228 subjects, based on the data in 2014TUS, and analyzed the differences in time use for occupation domains by age group. RESULTS: It was found that a greater amount time used for outdoor leisure activities yielded a higher life satisfaction value. Differences were found in time use by occupation domains between younger and older groups. These showed higher life satisfaction for those with spouses, regular full-time jobs, higher education, and better health. CONCLUSION: Based on these results, in order to improve the quality of life (QoL) for older adults, it is necessary to develop various leisure programs that require dynamic physical activities and to prepare alternative policies at the national level to promote participation in leisure activities by older adults. This study will provide occupational therapists (OTs) with data they can use to help older adults who have difficulty in time usage through time management intervention to improve their life satisfaction and QoL.

The Clinical Utilization of Radiation Therapy in Korea between 2011 and 2015.

PURPOSE: The purpose of this study was to estimate the clinical utilization of radiation therapy (RT) in Korea between 2011 and 2015. MATERIALS AND METHODS: We analyzed the claims data from the Health Insurance Review and Assessment Service to estimate the clinical utilization of RT. The source population consisted of all patients who had any of the International Classification of Diseases 10th revision cancer diagnoses (C00-C97) and those with diagnostic codes D00-D48, who were also associated with at least one of the procedure codes related to RT. RESULTS: The total number of patients who received RT in 2011, 2012, 2013, 2014, and 2015 were 54,810, 59,435, 61,839, 64,062, and 66,183, respectively. Among them, the total numbers of male and female patients were 24,946/29,864 in 2011, 27,211/32,224 in 2012, 28,111/33,728 in 2013, 29,312/34,750 in 2014, and 30,266/35,917 in 2015. The utilization rate of RT in cancer patients has also increased steadily over the same period from 25% to 30%. The five cancers that were most frequently treated with RT between 2011 and 2012 were breast, lung, colorectal, liver, and uterine cervical cancers. However, the fifth most common cancer treated with RT that replaced uterine cervical cancer in 2013 was prostate cancer. More than half of cancer patients (64%) were treated with RT in the capital area (Seoul, Gyeonggi, and Incheon). CONCLUSION: The total number of patients who underwent RT increased steadily from 2011 to 2015 in Korea. The utilization rate of RT in cancer patients is also increasing.

Prediction of Response to Stereotactic Radiosurgery for Brain Metastases Using Convolutional Neural Networks.

BACKGROUND: It is unclear whether radiomic phenotypes of brain metastases (BM) are related to radiation therapy prognosis. This study assessed whether a convolutional neural network (CNN)-based radiomics model which learned computer tomography (CT) image features with minimal preprocessing, could predict early response of BM to radiosurgery. MATERIALS AND METHODS: Tumor images of 110 BM post stereotactic-radiosurgery (SRS) (within 3 months) were assessed (Response Evaluation Criteria in Solid Tumor, version 1.1) as responders (complete or partial response) or non-responders (stable or progressive disease). Datasets were axial planning CT images containing the tumor center, and the tumor response. Datasets were randomly assigned to training, validation, or evaluation groups repeatedly, to create 50 dataset combinations that were classified into five groups of 10 different dataset combinations with the same evaluation datasets. The CNN learned using training-group images and labels. Validation datasets were used to choose the model that best classified evaluation images as responders or non-responders. RESULTS: Of 110 tumors, 57 were classified as responders, and 53 as non-responders. The area under the receiver operating characteristic curve (AUC) of each CNN model for 50 dataset combinations ranged from 0.602 [95% confidence interval (CI)=36.5-83.9%] to 0.826 [95% CI, 64.3-100%]. The AUC of ensemble models, which averaged prediction results of 10 individual models within the same group, ranged from 0.761 (95% CI=55.2-97.1%) to 0.856 (95% CI=68.2-100%). CONCLUSION: A CNN-based ensemble radiomics model accurately predicted SRS responses of unlearned BM images. Thus, CNN models are able to predict SRS prognoses from small datasets.

Stereotactic body radiation therapy for liver oligo-recurrence and oligo-progression from various tumors.

PURPOSE: To evaluate the outcomes of stereotactic body radiation therapy (SBRT) for patients with liver oligo-recurrence and oligo-progression from various primary tumors. MATERIALS AND METHODS: Between 2002 and 2013, 72 patients with liver oligo-recurrence (oligo-metastasis with a controlled primary tumor) and oligo-progression (contradictory progression of a few sites of disease despite an overall tumor burden response to therapy) underwent SBRT. Of these, 9 and 8 patients with uncontrollable distant metastases and patients immediate loss to follow-up, respectively, were excluded. The total planning target volume was used to select the SBRT dose (median, 48 Gy; range, 30 to 60 Gy, 3-4 fractions). Toxicity was evaluated using the Common Toxicity Criteria for Adverse Events v4.0. RESULTS: We evaluated 55 patients (77 lesions) treated with SBRT for liver metastases. All patients had controlled primary lesions, and 28 patients had stable lesions at another site (oligo-progression). The most common primary site was the colon (36 patients), followed by the stomach (6 patients) and other sites (13 patients). The 2-year local control and progression-free survival rates were 68% and 22%, respectively. The 2- and 5-year overall survival rates were 56% and 20%, respectively. The most common adverse events were grade 1-2 fatigue, nausea, and vomiting; no grade ≥3 toxicities were observed. Univariate analysis revealed that oligo-progression associated with poor survival. CONCLUSION: SBRT for liver oligo-recurrence and oligo-progression appears safe, with similar local control rates. For liver oligo-progression, criteria are needed to select patients in whom improved overall survival can be expected through SBRT.

The Clinical Status of Radiation Therapy in Korea in 2009 and 2013.

PURPOSE: The purpose of this study is to estimate the clinical status of radiation therapy (RT) in Korea. MATERIALS AND METHODS: We analyzed open claims data from the Health Insurance Review and Assessment Service (HIRA). The subjects were patients with malignant neoplasms who had procedure codes concerning RT in 2009 and 2013. RESULTS: The total numbers of patients who underwent RT in 2009 and 2013 were 42,483 and 56,850, respectively. The numbers of men and women were 20,012 and 22,471 in 2009 and 26,936 and 29,914 in 2013, respectively. The five most frequent RT sites were metastatic, breast, gastrointestinal, thoracic, and gynecologic cancers in 2009, and metastatic, breast, gastrointestinal, thoracic and head and neck cancers in 2013. The three leading types of cancer among men were metastatic, gastrointestinal, and thoracic, and breast, metastatic, and gynecologic among women. According to age, the most common treatment site was the central nervous system for those aged 20 years or less, the breast for those in their 30s to 50s, and metastatic sites for those in their 60s or older. CONCLUSION: Data from this study provide an overview of the clinical status of RT in Korea.

The clinical utilization of radiation therapy in Korea between 2009 and 2013.

PURPOSE: The purpose of this study was to estimate the clinical utilization of radiation therapy (RT) in Korea between 2009 and 2013. MATERIALS AND METHODS: We analyzed open claims data from the Health Insurance Review and Assessment Service. The subjects were patients who had diagnostic codes C00-C97 or D00-D48 according to the 10th revision of the International Classification of Diseases, with procedure codes indicating RT treatment. RESULTS: The total number of patients who received RT in 2009, 2010, 2011, 2012, and 2013 were 45,571, 49,593, 54,671, 59,172, and 61,485, respectively. Among them, the total numbers of male and female patients were 20,780/24,791 in 2009, 22,711/26,882 in 2010, 24,872/29,799 in 2011, 27,101/32,071 in 2012, and 27,941/33,544 in 2013. The five cancers that were most frequently treated with RT between 2009 and 2012 were breast, lung, colorectal, liver, and uterine cervical cancers. However, the fifth most common cancer treated with RT that replaced uterine cervical cancer in 2013 was prostate cancer. The three leading types of cancer among the male patients were lung, colorectal, and liver cancers, whereas in female patients, they were breast, uterine cervical, and lung cancers. The type of cancer most commonly treated by RT was cancer of the central nervous system in patients aged 20 years or less, breast cancer in patients aged 30-50 years, and lung cancer in patients aged 60 years or more. CONCLUSION: Data from this study provided the clinical utilization of RT in Korea between 2009 and 2013.

Effect of computer-based cognitive rehabilitation (CBCR) for people with stroke: a systematic review and meta-analysis.

OBJECTIVE: We conducted a systematic review and meta-analysis to identify the effect of computer-based cognitive rehabilitation (CBCR) on improving cognitive functions in patients with stroke. METHODS: Researchers performed a literature search using computerized databases such as the Cochrane Database, EBSCO (CINAHL), PsycINFO, PubMed and Web of Science. The following keywords were used: stroke, computer-based, cognitive rehabilitation, and others. The methodological quality was evaluated. Statistical heterogeneity and standardized mean difference were used to compute the overall effect size and that of subgroups. Also publication bias of the selected studies was analysed. RESULTS: Twelve studies met the inclusion criteria including a total of 461 stroke survivors. Among studies, six RCT studies were rated as high methodological quality. Overall effect size was medium 0.54, and the 95% confidence interval was 0.33-0.74. The effect sizes of acute and chronic phase of stroke were both 0.54. They can be interpreted as medium effect size and were statistically significant. The statistical heterogeneity and publication bias were not significant. CONCLUSION: The present study provides evidence that CBCR is effective on improving cognitive function after stroke. We recommend conducting meta-analysis on subgroups of CBCR programs in further studies.

Effects of functional task training with mental practice in stroke: a meta analysis.

OBJECTIVE: Meta analysis of studies was carried out to examine the effectiveness of functional task training with mental practice on functional performance following stroke. SEARCH STRATEGY: An exhaustive search was conducted using computerized databases such as MEDLINE, PubMed, Cochrane, PsycINFO, and EBSCO (CINAHL). SELECTION CRITERIA: The search was performed using the following keywords: stroke, functional task, mental practice, randomized controlled trial. DATA COLLECTION AND ANALYSIS: Two reviewers independently retrieved appropriate RCTs, extracted data, and assessed the methodological quality of each study. Selected studies needed to report the statistical values necessary for calculating the effect size, which was estimated using the standardized difference of the mean. Statistical heterogeneity and publication bias were also investigated. RESULTS: The five studies included 146 participants. The overall effect size was moderate (0.51, p < 0.001). The 95% confidence interval was from 0.27 to 0.75. Significant heterogeneity and publications bias were not founded. CONCLUSION: The present study is the first meta-analysis conducted on the effectiveness of functional task training with mental practice in stroke. The results indicate the clinical effectiveness of functional task training with mental practice provided by occupational and physical therapists in stroke rehabilitation.