1.
Mol Cell
; 84(9): 1635-1636, 2024 May 02.
Artículo
en Inglés
| MEDLINE
| ID: mdl-38701740
RESUMEN
In a recent publication in Nature, Xu et al.1 discovered a role of CRL5-SPSB3 ubiquitin ligase in promoting ubiquitination and degradation of nuclear cGAS, which prevents aberrant cGAS activation by genomic DNA and contributes to the maintenance of immune homeostasis.
Asunto(s)
Homeostasis , Nucleotidiltransferasas , Ubiquitinación , Nucleotidiltransferasas/metabolismo , Nucleotidiltransferasas/genética , Humanos , Ubiquitina-Proteína Ligasas/metabolismo , Ubiquitina-Proteína Ligasas/genética , Núcleo Celular/metabolismo , Proteolisis , Animales
2.