RESUMEN
A rat model of surgically induced reflux recapitulates the development and progression of human esophageal adenocarcinoma (EAC). In this study, reflux was induced in rats followed by postoperative endoscopy with biopsy, to diagnose and monitor disease progression. Overall, percentage agreement between visual endoscopy and gold standard histology was 95%, with disease-specific classification accuracies of 100% and 75% for Barrett's with dysplasia and EAC, respectively. Additionally, the percentage agreement for biopsy in tumors >4 mm was 75%. Thereby, establishing endoscopic evaluation as a reliable tool to assess disease progression and provide biopsies for downstream correlates in a de novo EAC model.
Asunto(s)
Adenocarcinoma/patología , Esófago de Barrett/patología , Descubrimiento de Drogas/métodos , Neoplasias Esofágicas/patología , Esofagoscopía , Esófago/patología , Reflujo Gastroesofágico/patología , Adenocarcinoma/tratamiento farmacológico , Adenocarcinoma/etiología , Animales , Antineoplásicos/farmacología , Esófago de Barrett/etiología , Biopsia , Modelos Animales de Enfermedad , Progresión de la Enfermedad , Neoplasias Esofágicas/tratamiento farmacológico , Neoplasias Esofágicas/etiología , Esofagostomía , Esófago/efectos de los fármacos , Esófago/cirugía , Reflujo Gastroesofágico/etiología , Yeyunostomía , Masculino , Valor Predictivo de las Pruebas , Ratas Sprague-Dawley , Reproducibilidad de los Resultados , Factores de Tiempo , Carga TumoralRESUMEN
Classic dengue fever presents with a triad of fever, headache, and rash. A "saddleback" fever pattern, morbilliform rash with islets of sparing after apyrexia, and hematological/hepatic abnormalities are common findings. As the most common arbovirus infection, dengue is a significant health threat to deployed military forces worldwide. preventive measures such as personal protective equipment and repellants should be employed by individuals and other preventive measures should be considered for units departing endemic areas. Due to the increased risk of severe or hemorrhagic syndromes in the case of reinfection, limiting redeployment of individuals who have been infected by dengue should be considered, and further research is needed in this area. Development of tetravalent or DNA-based vaccines should be a priority to improve health protection for deploying forces.